Term
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Definition
Benedryl = 1st generation
good as oral/topical antihistamine
crosses BBB and causes sedation
CROSS REACTION AS ANTI-MUSCARINIC WHICH CAUSES DRY MOUTH, INCREASE HR, CONSTIPATION
CONTRAINDICTATED IN NURSING MOTHER,NEONATES
Most effective prior to histamine release |
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Term
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Definition
1st generation antihistamine
useful in treating motion sickness/vomiting post surgical
Increases BP, can cause rash, drowsyness
RAPID ONSET |
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Term
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Definition
1st generation antihistamine for depressed people
may cause disorientation
CYP450 METABOLISM AND DISORIENTATION |
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Term
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Definition
Allegra = 2nd generation antihistamine
sedation at high concentrations
medium duration |
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Term
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Definition
zyrtec = 2nd generation effective long lasting antihistamine
drowsy at high doses |
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Term
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Definition
(claritin) 2nd generation antihistamine METABOLISED CYP450 Liver
long lasting |
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Term
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Definition
clarinex = 2nd generation active metabolite of loratidine
effective but drowsy at higher concentrations |
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Term
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Definition
1st - met liver excreted urine
2nd - excreted unchanged urine |
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