Term
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Definition
Class: antihistamine, H1 antagonist, 1st gen
Mechanism: antagonist at H1 receptors, some antimuscarinic activity
Indication: acute allergic rxn, reduce itching, diminish cold and flu symp, sleep aid, prophylaxis and tx motion sickness, REDUCE PARKINSON'S SYMPTOMS
Adverse effects: "drowsiness, sedation"; dizziness, lassitude, fatigue, nervousness, insomnia, tremor, loss of appetite, nausea, vomit, hypersensitivity rxn, dry mouth, blurred vision, urinary retention
Pharmacokinetics:
Absorption - well in GI
Distribution - hihgly lipid soluble, easy to CNS
Metabolism - extensive |
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Term
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Definition
Class: antihistamine, H1 antagonist, 1st gen
Mechanism: antagonist at H1 receptors, some antimuscarinic activity
Indication: acute allergic rxn, reduce itching, diminish cold and flu symp, sleep aid, prophylaxis and tx motion sickness, TX N AND V
Adverse effects: "drowsiness, sedation"; dizziness, lassitude, fatigue, nervousness, insomnia, tremor, loss of appetite, nausea, vomit, hypersensitivity rxn, dry mouth, blurred vision, urinary retention
Pharmacokinetics:
Absorption - well in GI
Distribution - hihgly lipid soluble, easy to CNS
Metabolism - extensive |
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Term
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Definition
Class: antihistamine, H1 antagonist, 1st gen
Mechanism: antagonist at H1 receptors, some antimuscarinic activity
Indication: acute allergic rxn, reduce itching, diminish cold and flu symp, sleep aid, prophylaxis and tx motion sickness
Adverse effects: "drowsiness, sedation"; dizziness, lassitude, fatigue, nervousness, insomnia, tremor, loss of appetite, nausea, vomit, hypersensitivity rxn, dry mouth, blurred vision, urinary retention
Pharmacokinetics:
Absorption - well in GI
Distribution - hihgly lipid soluble, easy to CNS
Metabolism - extensive |
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Term
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Definition
Class: antihistamine, H1 antagonist, 2nd gen
Mechanism: antagonist at H1 receptors
Indication: acute allergic rxn, reduce itching, diminish cold and flu symp
Adverse effects: less sedation and drowsiness, (no antimuscarinic)
Pharmacokinetics:
Absorption - well in GI
Distribution - not much to CNS, ionized at pH7.4, highly bound to albumin
Metabolism - P450 system |
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Term
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Definition
Class: antihistamine, H1 antagonist, 2nd gen
Mechanism: antagonist at H1 receptors
Indication: acute allergic rxn, reduce itching, diminish cold and flu symp
Adverse effects: less sedation and drowsiness, (no antimuscarinic)
Pharmacokinetics:
Absorption - well in GI
Distribution - not much to CNS, ionized at pH7.4, highly bound to albumin
Metabolism - P450 system |
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Term
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Definition
Class: antihistamine, H1 antagonist, 2nd gen
Mechanism: antagonist at H1 receptors
Indication: acute allergic rxn, reduce itching, diminish cold and flu symp
Adverse effects: less sedation and drowsiness, (no antimuscarinic)
Pharmacokinetics:
Absorption - well in GI
Distribution - not much to CNS, ionized at pH7.4, highly bound to albumin
Metabolism - P450 system |
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Term
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Definition
Class: antihistamine, H1 antagonist, 2nd gen
Mechanism: antagonist at H1 receptors
Indication: acute allergic rxn, reduce itching, diminish cold and flu symp
Adverse effects: less sedation and drowsiness, (no antimuscarinic)
Pharmacokinetics:
Absorption - well in GI
Distribution - not much to CNS, ionized at pH7.4, highly bound to albumin
Metabolism - P450 system |
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Term
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Definition
Class: migraine,
Mechanism: activates subset of 5HT receptors; direct vasoconstrictor on intracranial blood vessels, presynaptic inhibition on sensory neurons
Indication: abortive drug class of choice for migraine +/- aura [not prophylaxis or long-term tx]
Contraindication: hx of ischemic or vasospastic CAD, cerebrovascular or periph vasc disease, uncontrolled hypertension, taking MAO inhibitors
Adverse effects: nausea, malaise, dizziness, weakness, dry mouth, paresthesia, pain at injection site; rare: serious CV complications (coronary artery spasm, ischemia, arrhythmias)
Pharmacokinetics:
Absorption - subq injection, oral, nasal spray; 15-40% bioavailability orally
Onset: 10-15min after injection or nasal spray |
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Term
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Definition
Class: migraine,
Mechanism: activates subset of 5HT receptors; direct vasoconstrictor on intracranial blood vessels, presynaptic inhibition on sensory neurons
Indication: abortive drug class of choice for migraine +/- aura [not prophylaxis or long-term tx]
Contraindication: hx of ischemic or vasospastic CAD, cerebrovascular or periph vasc disease, uncontrolled hypertension, taking MAO inhibitors, SEVERE RENAL OR HEPATIC DISEASE
Adverse effects: nausea, malaise, dizziness, weakness, dry mouth, paresthesia, pain at injection site; rare: serious CV complications (coronary artery spasm, ischemia, arrhythmias)
Pharmacokinetics:
Absorption - subq injection, oral, nasal spray; 15-40% bioavailability orally
Onset: 10-15min after injection or nasal spray |
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Term
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Definition
Class: migraine,
Mechanism: activates subset of 5HT receptors; direct vasoconstrictor on intracranial blood vessels, presynaptic inhibition on sensory neurons
Indication: abortive drug class of choice for migraine +/- aura [not prophylaxis or long-term tx]
Contraindication: hx of ischemic or vasospastic CAD, cerebrovascular or periph vasc disease, uncontrolled hypertension, taking MAO inhibitors
Adverse effects: nausea, malaise, dizziness, weakness, dry mouth, paresthesia, pain at injection site; rare: serious CV complications (coronary artery spasm, ischemia, arrhythmias)
Pharmacokinetics:
Absorption - subq injection, oral, nasal spray; 15-40% bioavailability orally
Onset: 10-15min after injection or nasal spray |
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Term
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Definition
Class: migraine,
Mechanism: activates subset of 5HT receptors; direct vasoconstrictor on intracranial blood vessels, presynaptic inhibition on sensory neurons
Indication: abortive drug class of choice for migraine +/- aura [not prophylaxis or long-term tx]
Contraindication: hx of ischemic or vasospastic CAD, cerebrovascular or periph vasc disease, uncontrolled hypertension, taking MAO inhibitors
Adverse effects: nausea, malaise, dizziness, weakness, dry mouth, paresthesia, pain at injection site; rare: serious CV complications (coronary artery spasm, ischemia, arrhythmias)
Pharmacokinetics:
Absorption - subq injection, oral, nasal spray; 15-40% bioavailability orally
Onset: 10-15min after injection or nasal spray |
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Term
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Definition
Class: migraine,
Mechanism: activates subset of 5HT receptors; direct vasoconstrictor on intracranial blood vessels, presynaptic inhibition on sensory neurons
Indication: abortive drug class of choice for migraine +/- aura [not prophylaxis or long-term tx]
Contraindication: hx of ischemic or vasospastic CAD, cerebrovascular or periph vasc disease, uncontrolled hypertension, taking MAO inhibitors
Adverse effects: nausea, malaise, dizziness, weakness, dry mouth, paresthesia, pain at injection site; rare: serious CV complications (coronary artery spasm, ischemia, arrhythmias)
Pharmacokinetics:
Absorption - subq injection, oral, nasal spray; 15-40% bioavailability orally
Onset: 10-15min after injection or nasal spray |
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Term
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Definition
Class: migraine, anticonvulsant
Mechanism: decrease frequency of migraines
Indication: migraine prophylaxis |
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Term
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Definition
Class: migraine
Mechanism: agonist and antagonist at many receptors; agonist at 5HT receptors
Indication: migraines
Contraindicated: pregnancy (uterine stimulant and restrict blood flow), CAD or PVD, hypertension, liver or renal disease
Adverse effects: nausea, vasoconstriction with ischemia, leg weakness, muscle pain |
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Term
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Definition
Class: migraine
Mechanism: agonist and antagonist at many receptors; agonist at 5HT receptors
Indication: migraines
Contraindicated: pregnancy (uterine stimulant and restrict blood flow), CAD or PVD, hypertension, liver or renal disease
Adverse effects: nausea, vasoconstriction with ischemia, leg weakness, muscle pain |
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Term
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Definition
Class: migraine
Mechanism: agonist and antagonist at many receptors; agonist at 5HT receptors; ANTAGONIST AT 5HT(2A/2C) RECEPTOR
Indication: migraine prophylaxis
Contraindicated: pregnancy (uterine stimulant and restrict blood flow), CAD or PVD, hypertension, liver or renal disease
Adverse effects: nausea, vasoconstriction with ischemia, leg weakness, muscle pain; long-term: RETROPERITONEAL, CARDIAC, OR LUNG FIBROSIS (USE <6MO ONLY) |
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