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Developed in the 1970's by German pharmaceutical firms Bayer and Merck. For Schistosomiasis and most flukes. It is a synthetic Isoquinolone-pyrazine derivative. |
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Developed by Dr. William Campbell of Merck; first benzimidazole to be developed and licensed for human use. |
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Introduction of organophosphate antihelminthics |
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An organophosphate antihelminthic that was eventually removed from the U.S market due to toxicity issues. |
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Modern age of deworming began. Administered to sheep as a drench and/or included in salt mixtures. Sometimes combined with lead arsenate to control tapeworms. |
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Filiariasis, Loaiasis, Tropical eosinophilia. Immobilizes microfilariae and alters their surface structe making them more susceptible to destruction by host defense mechanism. |
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Strongyloides and Onchocerciasis. Alternative drug for scabies. |
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Used if the patient is allergic to Albendazole and Mebendazole. Broad Sprectum. Excreted in the unchanged form (no metabolism) |
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Hepatotoxic 2-Substituted benzimidazole. |
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Obsolete Drug. Contraindicated in neurological disorder patients (epilepsy, parkinson's disease) |
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Broad spectrum anti-helminthic drug. Chemistry: Benzimidazolecarbamate. |
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Tapeworm. Salicylamide derivative. |
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