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Antihelminthic Drugs
Credits to Lipincott's :> For studying only
13
Pharmacology
Undergraduate 3
12/06/2013

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Term
praziquantel
Definition
Developed in the 1970's by German pharmaceutical firms Bayer and Merck.
For Schistosomiasis and most flukes.
It is a synthetic Isoquinolone-pyrazine derivative.
Term
Thiabendazole
Definition
Developed by Dr. William Campbell of Merck; first benzimidazole to be developed and licensed for human use.
Term
1960's and 1970's
Definition
Introduction of organophosphate antihelminthics
Term
Haloxon
Definition
An organophosphate antihelminthic that was eventually removed from the U.S market due to toxicity issues.
Term
phenothiazine
Definition
Modern age of deworming began. Administered to sheep as a drench and/or included in salt mixtures. Sometimes combined with lead arsenate to control tapeworms.
Term
Diethylcarbamazine
Definition
Filiariasis, Loaiasis, Tropical eosinophilia.
Immobilizes microfilariae and alters their surface structe making them more susceptible to destruction by host defense mechanism.
Term
Ivermectin
Definition
Strongyloides and Onchocerciasis.
Alternative drug for scabies.
Term
Mebendazole
Definition
Relatively toxic drug.
Term
pyrantel pamoate
Definition
Used if the patient is allergic to Albendazole and Mebendazole.
Broad Sprectum.
Excreted in the unchanged form (no metabolism)
Term
Thiabendazole
Definition
Hepatotoxic 2-Substituted benzimidazole.
Term
piperazine
Definition
Obsolete Drug.
Contraindicated in neurological disorder patients (epilepsy, parkinson's disease)
Term
Albendazole
Definition
Broad spectrum anti-helminthic drug.
Chemistry: Benzimidazolecarbamate.
Term
Niclosamide
Definition
Tapeworm.
Salicylamide derivative.
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