Tx: Aspergillosis, candidiasis

-inhibits cell wall synth by inhibitin 1,3-beta glucan synthase (glucans major component of cell walls)

*cyclosporine w/ can cause hepatotoxicity

Polyene antifungal

Binds ergosterol and forms pores in membrane

Tx: drug of choice for cryptococcal meningitis

**Amphoterrible: "Shake and Bake", Nephrotoxicity, arrhythmias

Interferes with ergosterol synthesis (^ squalene in cell)

Tx: Dermatophyte (tinea, nail fungus)

highly lipophilic (concentrates in nails)

*Avoid in pregnancy

Interfere with ergosterol synthesis (via P450 enzyme)

Tx: superficial and systemic fungal infxns, cryptococcal meningitis NOT aspergillosis

*inhibits CYP3A4

Interfere with ergosterol synthesis (via P450 enzyme)

Tx: Broad spec antifungal

*Contraindicated in heart failure

**inhibits CYP3A4

Cytosine nucleoside analogue (fungi convert drug to 5-fluorouracil via Cytosine Deaminase)

Tx: Candida, Crypto (used with Amp B)

*Can cause bone marrow suppression, ^ liver enzymes

Binds microtubules (mitosis inhibitor)

Tx: Treats dermatophytes and ringworm

Induces CYPs= ^ metabolism of warfarin & decrease efficacy of oral contraceptives

*Teratogenic and carcinogenic at high doses

Binds DHFR with more affinity than human, and binds Dihydrobiopteroate (not present in mammals)

Tx: PCP

*Rash, hepatitis, neutropenia, azotemia, thrombocytopenia

Antifungal for treating PCP, leischmaniasis, african trypanosomiasis

*Nephrotoxicity, fatal arrhythmias and heart failure, hypoglycemia

-Watch blood chemistries