Term
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Definition
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Term
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Definition
Binds egosterol to disrupt fungal membrane |
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Term
Ampho-B role of deoxycholate |
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Definition
Must be compexed to deoxycholate for solubitliy |
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Term
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Definition
IV Intrathecally bladder wash |
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Term
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Definition
Systemic fungal infections |
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Term
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Definition
Attacks renal cells and RBC's K, Mg, HCO3 wasting- hydrate and monitor Infusion related- fever, chills, riggor, hypotenstion, myalgia, arthralgia, HA- premedicate with APAP, NSAIDS and others Thrombophlebitis- prevent with heparin Amenia- suppresses EPO |
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Term
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Definition
Better formulations dec nephrotoxicity and allow larger doses BUT don't do anything for rigor and infusion rxn much more expensive |
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Term
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Definition
binds to ergosterol and disrupts membrane |
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Term
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Definition
oral, vaginal, skin candidiasis |
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Term
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Definition
topical swish and swallow not orally absorbed |
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Term
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Definition
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Term
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Definition
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Term
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Definition
Flucytosine --> 5- Flurouridylic acid via cytosine deaminase--> inhibits translation 5- Flurodeoxyuridylic acid --> inhibits thymylate synthase --> inhibits DNA synthesis |
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Term
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Definition
used with Amphoteracin B for cryptococcal meningitis Never use alone, resistance develops to quickly |
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Term
Flucytosinse- administration |
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Definition
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Term
Flucytosine- distribution |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
Bone marrow suppression GI- N/V/D Livertoxicity- reversible |
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Term
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Definition
Caspofugin Micafugin Andidafugin |
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Term
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Definition
inhibit beta 1,3 glucan synthesis- inhibit cell wall production |
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Term
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Definition
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Term
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Definition
systemic Candida or Apergillus infections |
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Term
Echinocandins - drug interactions |
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Definition
Cyclosporine inc blood levels of Caspofugin |
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Term
Echinocandins- Protein binding |
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Definition
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Term
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Definition
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Term
Echinocandins- CNS penetration |
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Definition
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Term
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Definition
Histamine related rxns- warmth, swelling, rash Headache Hepatotoxicity |
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Term
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Definition
Inhibits mitotic spindle formation binds to human keratin which prevents invasion of fungus. Infected cells slough off eventually non-infected keratinocytes at the basal layer eventually replace |
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Term
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Definition
Oral- best with fatty foods |
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Term
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Definition
Fungal infections of: Hair, skin, and nails |
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Term
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Definition
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Term
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Definition
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Term
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Definition
Headache, Hepatotoxicity, Neuro/leuckopenia, basophilia, photosensitivity, GI, Rash |
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Term
Griseofluvin- Effect on enzymes |
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Definition
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Term
Griseofluvin- Drug interactions |
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Definition
Inc metabolism of Warfarin and Oral contraceptives |
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Term
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Definition
binds squalene epoxidase --> inhibits ergosterol synthesis |
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Term
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Definition
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Term
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Definition
Mycoses of nails, drug accumulates in the nail beds |
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Term
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Definition
400 hrs b/c accumulates in hair, skin, and fat and slowly releases |
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Term
Terbinafine- Protein binding |
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Definition
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Term
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Definition
Well tolerated Uncommon AE- GI, hepatatoxicity, stevents Johnson syndrome |
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Term
Terbinafine- drug interactions |
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Definition
Cimetidine- increases levels of Terbinafine |
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Term
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Definition
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Term
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Definition
Ketoconazole, Clotrimazole, Miconazole, Econazole, Butoconazole, Oxiconazole |
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Term
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Definition
All topical except Ketoconazole which is for systemic |
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Term
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Definition
Terconazole, Itraconazole, Fluconazole, Voriconazole, Poscanzole |
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Term
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Definition
All systemic except for Terconazole which is topical |
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Term
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Definition
bind 14 alpha demethylase --> inhibit ergosterol synthesis |
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Term
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Definition
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Term
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Definition
Mostly, topical, but some systemic Superficial infections- ringworm, candidiasis, tinea versicolor/ nigra, fungal keratitis NOT FOR NAIL/HAIR- THOSE REQ SYSTEMIC |
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Term
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Definition
Oral. Require acidic environment for absorption. Drugs that inhibit acidity in the stomach dec absorption (Histamine2 and PPI) |
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Term
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Definition
Inhibitor Inc levels of other drugs |
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Term
Ketoconazole- AE- hormonal effects |
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Definition
Hormonal due to CYP450 inhib- dec libido, gynecomastia, menstral irregularities. Blocks androgen, cortisol, aldosterone syntehsis and adronergic receptor antagonist |
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Term
Ketoconazole- AE- non hormonal |
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Definition
GI- dose dependent rash hepatotoxicity |
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Term
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Definition
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Term
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Definition
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Term
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Definition
GI absorption- empty stomach and acid |
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Term
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Definition
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Term
Itraconazole- protein binding |
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Definition
protein binding parent and metabolites |
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Term
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Definition
GI, Rash, LFTs. hypoTG, Hypokalemia |
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Term
Itraconazole- drug interactions |
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Definition
Fatal arrhythmia if given with cisapride or quinidine |
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Term
Intriconazole- Liver enzyme |
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
Fluconazole- protein binding |
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Definition
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Term
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Definition
Reversible alopecia GI, Rash, LFTs |
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Term
Fluconazole- Contraindications |
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Definition
Pregnancy- results in fatal skeletal and cardiac muscle deformities |
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Term
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Definition
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Term
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Definition
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Term
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Definition
variable- dependson drug concentration, non linear kinetics |
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Term
Voriconazole- liver enzymes |
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Definition
Potent CYP3A4 inhibitor--> drug interactions |
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Term
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Definition
Visual changes, Cardiovascular, CNS Rash, LFTs |
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Term
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Definition
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Term
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Definition
Candida, Apergillus, Zygomycetes |
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Term
Posconazole- protein binding |
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Definition
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Term
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Definition
hepatic metabolism --> feces |
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Term
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Definition
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Term
Posconazole- liver enzymes |
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Definition
CYP3A4- moderate inhibitor |
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Term
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Definition
Cardiovacular- HTN, hpokalemia CNS- headache, dizziness GI, LFTs |
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