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Antidiabetics
Part 2
24
Nursing
Graduate
11/17/2014

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Term
WHAT ARE BENEFITS OF EXOGENOUS HUMAN PRODUCED RECOMBINANT DNA INSULIN? 3 ANSWERS
Definition
DECREASED SIDE EFFECT AND DECREASED ALLERGENIC POTENTIAL, LESS ANTIBODY PRODUCTION (HELPS PREVENT RESISITANCE), AND DECREASED PROBLEMS WITH LIPODYSTROPHY (FATTY TISSUE BREAKDOWN).
Term
U100 INSULIN IS WHAT?
Definition
100UNITS/ML
Term
FOR HYPOGLYCEMIA WHAT SHOULD YOU GIVE TO INCREASE GLUCOSE IF D50 ISN'T AVAILALBE?
Definition
GLUCAGON 1MG IM
Term
1ML OF D50 INCREASES BLOOD GLUCOSE BY HOW MUCH?
Definition
2MG/DL
Term
WHAT IS THE ONLY INSULIN THAT CAN BE GIVEN IV?
Definition
REGULAR INSULIN
Term
WHAT IS THE CIRCULATING 1/2 LIFE OF REGULAR INSULIN?
Definition
6 MINUTES BUT DOA IS LONGER
Term
1 UNIT OF REGULAR INSULIN IV SHOULD DECREASE BLOOD GLUCOSE BY WHAT?
Definition
25-30MG/DL
Term
FOR NPH INSULIN WHAT DOES PROTAMINE DO?
Definition
SLOWS ABSORPTION TO PROLONG ACTION
Term
NPH IS MROE PRONE TO WHAT TYPE OF REACTIONS?
Definition
PROTAMINE REACTIONS
Term
WHAT DOES PRANDIAL INSULINS MEAN?
Definition
SHORT ACTING INSULINS. YOU GIVE THESE AFTER MEALS (ASPART, LISPRO, GLULISINE, REGULAR)
Term
WHAT DOES BASAL INSULINS MEAN?
Definition
LONGER ACTING (NPH, GLARGINE, DETEMIR)
Term
WHAT IS THE AVERAGE ONSET, PEAK, AND DURATION FOR PRANDIAL INSULINS?
Definition
ONSET IS 15 MINUTES, PEAK IS 30 MINUES, AND DURATION IS 3 HRS
Term
WHAT IS THE ONSET, PEAK, AND DURATION OF BASAL INSULINS?
Definition
ONSET IS 1 HR, PEAK IS N/A, DURATION IS 24 HRS
Term
A-GLUCOSIDASE INHIBITORS ARE ALSO KNOWN AS WHAT?
Definition
STARCH BLOCKERS
Term
NAME 2 A-GLUCOSIDASE INHIBITORS.
Definition
ACARBOSE AND MIGLITOL
Term
HOW DOES A-GLUCOSIDASE INHIBITORS WORK?
Definition
INHIBIT OR DELAY ABSORPTION OF DIETARY CARBOHYDRATES BY INHIBITING THE BREAKDOWN OF COMPLEX CARBOHYDRATES TO GLUCOSE. IT LOWERS POSTPRANDIAL HYPERGLYCEMIA
Term
A-GLUCOSIDASE INHIBITORS ARE INLY EFFECTIVE WHEN TAKEN WITH WHAT?
Definition
WITH MEALS.
Term
IS THERE RISK OF HYPOGLYCEMIA WITH A-GLUCOSIDASE INHIBITORS?
Definition
NO.
Term
WHAT IS A SIDE EFFECT OF A-GLUCOSIDASE INHIBITORS?
Definition
GI DISTURBANCES
Term
WHAT IS THE MOA OF SULFONYUREAS?
Definition
STIMUALTE THE SECRETION OF INSULIN AND DECREASE THE SECRETION OF GLUCAGON. NORMALLY WHEN K EFFLUXES YOU HAVE HYPERPOLARIZATION OF THE CELL. INHIBITS K ATPASE CHANELS ON THE PANCREATIC BETA CELLS WHICH PREVENTS K EFFLUX. IT THEREFORE DEPOLARIZES CELLS TO RELEASE INSULIN.
Term
ARE SULFONYUREAS WELL ABSORBED AND PROTEIN BOUND?
Definition
THEY ARE WELL ABSORBED AND ARE HIGHLY PROTEIN BOUND TO ALBUMIN (INTERACTIONS WITH OTHER PROTEIN BOUND DURGS)
Term
WHAT IS THE METABOLISM AND EXCRETION OF SULFONYLUREAS?
Definition
HEPATIC AND RENAL
Term
WHAT ARE 3 SIDE EFFECTS OF SULFONYUREAS?
Definition
HYPOGLYCEMIA (INCREASE INSULIN SECRETION *NOT* BLOCKING DIETARY UPTAKE; WEIGHT GAIN; ALLERGIC REACTIONS IN PATIENTS WITH SULFA ALLERGIES
Term
NAME 3 SULONYLUREAS.
Definition
GLYBURIDE, GLIPIZIDE, AND GLIMEPIRIDE
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