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| block reuptake of NE and 5HT into the presynaptic neurons. Block alpha adrenergiv, histamine and muscarinic receptors |
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| weight gain, sedation, xerostomia, urinary retention, constinpation, blurred vision, glaucoma, o-htn, reflex tachycardia, fatal arrhythmias |
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| Fluoxetine (Prozac, Sarfafem) |
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| Selective inhibition of serotonin reuptake |
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| moderate to severe depression, some panic deisorders, bed wetting |
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| major depresssion, OCD, bulimia/anorexia, panic disorder, PMDD, postmenopausal syndrome |
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| Nausea, sleep disturbances, sexual dysfunction, GI, anorexia, weight loss, increase suicidal ideation, serotonin symptom |
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| depression associated with neuropathic pain |
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| fewer side effects; less adrenergic, muscarinic, histaminergic receptor blockade |
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| Bupropion (Wellbutrin, Zyban) |
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| Atypical antidepressants- weak NE/DA reuptake inhibitor; less anticholinergic, antihistamine, alpha blockade; little sexual dysfunction- lowers seizure threshold |
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| Atypical antidepressants- alpha 2 antagonist, increase 5HT and NE neurotransmission ; Serotonin 5HT2 receptor antagonist, has antihistamine actions (H1) |
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| Atypical antidepressants- 5HT2a antagonist; weak 5HT reuptake inhibitor, antihistamine (H1)actions, decrease sexual dysfunction, priapism |
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| Atypical antidepressants- 5HT2a antagonist; weak 5HT reuptake inhibitor, antihistamine (H1)actions, decrease sexual dysfunction- pulled due to hepatotoxicity |
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| Tranylcypromine (Parnate) |
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| Selegiline (Eldepryl, Zelapar) |
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| inhibit monoamine oxidase; increase stores of intraneuronal NE, DA, 5HT |
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| only used in pt refractory or hypersensitive to other antidepressants; strong anxiety, phobic states, atypical depression |
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Tyramine:Headache, hypertension, stroke;
Drowsiness, Orthostatic hypotension, Blurred vision, Xerostomia, Constipation/urinary retention- diet restriction |
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| Potentially fatal interaction caused by the combination of two or more drugs that enhance serotonin transmission; anxiety, shivering, tremor, diaphoresis, malignant hyperthermia |
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| TX for manic-depressive disorder |
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| tremors, weight gain, confusion, convulsion, drug interactions with NSAIDs |
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| Symbyax (Olanzapine + Fluoxetine) |
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| TX for manic depressive disorder- atypical antispychotic + SSRI antidepressant |
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| Carbamazepine (Tegretol, Epitol) |
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| TX for Bipolar disorder- Anticonvulsants: mood stabilizers |
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| Valproic Acid (Depakote, Dpakene, Depacon) |
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| TX for Bipolar disorder- Anticonvulsants: mood stabilizers |
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| TX for Bipolar disorder- Anticonvulsants: mood stabilizers |
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