Term
|
Definition
Antiplatelet
inhibits cyclooxygenase (AA -> TXA2)
81 mg/d
prolongs bleeding time |
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Term
|
Definition
Antiplatelet
inhibits PDE activity
coronary vasodilation -> decreases adhesion |
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Term
|
Definition
antiplatelet
inhibit binding of ADP and incraese cAMP levels
prolongs bleeding time
s/e: thrombocytopenia, leukopenia |
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Term
|
Definition
antiplatelet
inhibits ADP binding
increases cAMP levels
prolongs bleeding time
less s/e than ticlopidine |
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Term
|
Definition
antiplatelet
Ab against GPIIb/IIIa
inhibits platelet aggregation
bleeding |
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Term
|
Definition
| antiplateletcyclic peptide inhibitor of fibrinogen binding to GPIIb/IIIa |
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Term
|
Definition
vitamin K antagonist
factors 2, 7, 9, 10
oral
crosses placenta
skin necrosis |
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Term
|
Definition
interacts with antithrombin to inhibit factors 9, 10, thrombin
IV
hemmorhage
HIT
does not cross placenta |
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|
Term
|
Definition
synthetic heparin
heparin-lite
only factor 10a
once/day
not for renal patients |
|
|
Term
| hirudin, lepirudin, bivalirudin |
|
Definition
antithrombin
tx of pts with HIT |
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Term
|
Definition
competitive inhibitor of thrombin
tx of HIT |
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Term
|
Definition
recombinant protein C
inhibits 5a, 8a |
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|
Term
|
Definition
thrombolytic
promotes plasminogen -> plasmin
s/e: hemmorhage
1st generation-not sensitive |
|
|
Term
tPAs
alteplase
reteplase
tenecteplase |
|
Definition
thrombolytic
bind selectively to fibrin
clot-sensitive fibrinolysis
re-establish in stroke |
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