Term
| WARFARIN'S STRUCTURE IS SIMILAR TO WHAT? |
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Definition
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Term
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Definition
| INHIBITS THE SYNTHESIS OF CLOTTING FACTORS II, VII, IX, AND X. BLOCS THE ACTIVITY OF VITAMIN K, WHICH PREVENTS CARBOXYLATION OF THESE FACTORS. |
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Term
| HOW DOES COUMADIN WORK IN THE PROTEIN C PATHWAY? |
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Definition
| INHIBITS PROTEIN C AND PROTEIN S |
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Term
| DOES COUMAIN DIRECTLY AFFECT PLT ACTIVITY? |
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Definition
| NO! MORE INDIRECT THRU BLOCKING FACTORS AND PROTEINS |
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Term
| IS COUMADIN WELL ABSORBED FROM THE GUT?> WHAT IS THE PKA? |
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Definition
| YES. WEAK ACID WITH PKA OF 5.1 |
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Term
| IS COUAMIN HIGHLY PROTEIN BOUND? WHAT CAN IT BE REMOVED FROM ALBUMIN BY? |
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Definition
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Term
| CAN COUMADIN CROSS THE PLACENTA? WHAT WOULD THAT CAUSE? |
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Definition
| YES. CAN CAUSE SEVERE FETAL BLEEDING AND BIRTH DEFECTS |
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Term
| WHAT IS THE ONSET OF COUMAIN? WHAT HAS THE SHORTEST HALF-LIFE? |
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Definition
| 12-24 HRS. FACTOR 7 HAS THE SHORTEST HALF LIFE OF ALL THE CLOTTING FACTORS (6 HRS) SO THE ONSET TAKES SEVERAL HALF-LIVES. |
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Term
| THE PEAK COAGULATION EFFECTS OF COUMADIN ARE WHEN? |
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Definition
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Term
| WHAT IS THE 1/2 LIFE, METABOLISM, AND EXCRETION OF COUMAIN? |
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Definition
| 24-36 HRS, HEPATIC BY CYP- 450, RENAL |
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Term
| WHAT ARE 2 SIDE EFFECTS WITH COUMAIN? |
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Definition
| BLEEDING AND SKIN NECROSIS (THRU PROTEIN C AND S INHIBITION CAUSING MICRO-CLOTS |
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Term
| COUMAIN EFFECTS ARE INCREASED BY WHAT 7 FACTORS? |
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Definition
| ASA, PLAVIX, NSAIDS, HEPATIC DISEASE, AMIODARONE, HYPERTHYROIDISM (FASTER PRODUCTION OF CLOTTING FACTORS), SOME CEPHALOSPORINS (ELIMINATE INTESTINAL BACTERIA THAT PRODUCE VITAMIN K) |
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Term
| COUMADIN EFFECTS ARE DECREASED BY WHAT 5 FACTORS? |
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Definition
| BARBS (CYP INDUCERS), CHOLESTYRAMINE (COMPETETION OF ABSORPTION), CHLORTHALIDONE (K-SPARING DIURETIC), PHENYTOIN, SPIRINOLACTONE (CAUSES INCREASED BLOOD VISCOSITY), HYPOTHYROIDISM |
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Term
| WRUGS THAT HAVE NO EFFECT ON WARFARIN'S ANTICOAGULANT EFFECTS ARE WHAT 4 DRUGS? |
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Definition
| TYLENOL, OPIOIDS, BENZOS, AND MOST ANTIBIOTICS |
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Term
| HOW DO WE MONITOR THE EFFECTIVNESS OF COUMADIN? |
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Definition
| PT AND INR WHICH IS A MORE ACCURATE JUDGMENT |
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Term
| WHICH PATHWAYS DOES COUMAIN WORK ON? |
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Definition
| EXTRINSIC AND COMMON PATHWAY |
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Term
| WHEN SHOULD COUMADIN BE DISCONTINUED PRIOR TO SURGERY? |
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Definition
| 3-5 DAYS PRIOR TO PROCEDURE, CHECK INR PREOPERATIVELY |
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Term
| WHAT SHOULD BE USED FOR REVERSAL FOR COUMAIN? |
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Definition
| FOR URGENT REVERSAL, VITAMIN K 1-10MG IV OR RECOMBINANT FACTOR VIIA OR 1-2 UNITS FFP (HAS ALL CLOTTING FACTORS) |
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