Term
|
Definition
Serine protease that activates plasminogen
Poor activator of plasminogen in absence of fibrin-binding
5-10 min T1/2 |
|
|
Term
|
Definition
Cyclooxygenase inh (permanent in platelets, temp in endothelium)
Prevents Thromboxane A2 activity |
|
|
Term
|
Definition
1. GI ulceration
2. Nephrotox
3. Hepatic inj
4. Airway hyperreactivity in asthma & Reye's |
|
|
Term
|
Definition
Inh purinergic receptors
Dec inh of adenyl cyclase
Inc cAMP |
|
|
Term
| Clopidogrel adverse effects |
|
Definition
Neutropenia w ticlopidine
Bleeding |
|
|
Term
|
Definition
Better tolerated and administered to pts w ahtersclerotic vascular disease
Used w aspirin in angioplasty and stenting procedures |
|
|
Term
|
Definition
Phosphodiesterase inh
Inc cAMP, dec plt aggregation
Used in combo w warfarin & aspririn
Expensive |
|
|
Term
| Dipyridamole adverse effects |
|
Definition
|
|
Term
| Direct acting anticoagulants |
|
Definition
|
|
Term
|
Definition
Prostacyclin analog
Stim adenyl cyclase, inc cAMP |
|
|
Term
|
Definition
| Inh glycoprotein rec IIb/IIIa |
|
|
Term
|
Definition
Direct-acting anticoagulant rx administered i.v.
Used following cardiac bypass, PE, acute MI, angioplasty, UA
Inc aPTT 1.5-2.5 times |
|
|
Term
|
Definition
1. Bleeding
2. Thrombocytopenia via development of IgG Ab against |
|
|
Term
| Heparin contraindications |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Accelerates Antithrombin III rxns
Antithrombin III interacts w activated factors IIa, Xa |
|
|
Term
| Indirect-acting anticoagulants |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Recombinant hirudin structurally identical to natural peptide
*(Hirudin direct thrombin inh from the salivary glds of the medicinal leech |
|
|
Term
|
Definition
| Ab to lepirudin may develop |
|
|
Term
| Low Molecular Weight Heparins |
|
Definition
Depolymerized Heparin
Greater bioavailibility and longer half-life after subQ injection
Generally does not require monitoring due to greater therapeutic index |
|
|
Term
| Low Molecular Weight Heparins adverse effects (2) |
|
Definition
|
|
Term
|
Definition
| inc cAMP which inh plt aggregation |
|
|
Term
|
Definition
Thrombolytic therapy that cleaves
plasminogen, producing plasmin
Large loading doses needed
Antibodies may develop cxing allergic rxn
40-80 min half life |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Indirect-acting anticoagulant |
|
|
Term
|
Definition
| Coadministration w albumin-bound rxs or rxs that affect P450 metabolism can influence plasma conc. |
|
|
Term
| Warfarin contraindications |
|
Definition
1. Pregnancy
2. Uncontrolled EtOH/Rx abuse
3. Unsupervised dementia/psychosis |
|
|
Term
|
Definition
|
|
Term
| Warfarin effect diminished w (3) |
|
Definition
Cholestyramine
Barbituates
Vit K |
|
|
Term
|
Definition
1. Chloral hydrate
2. Chloramphenicol
3. Broad-spec abiotics
4. Anabolic steroids |
|
|
Term
|
Definition
Bleeding
Teratogenicity
Drug interactions |
|
|
Term
|
Definition
| Warfarin blocks vit K epoxide reductase step in cycling of gamma-carboxylation of glutamate residues on clotting factor proteins necessary for Ca binding |
|
|
Term
|
Definition
Prophylaxis or treatment of:
Venous thrombosis
PE
Cardiac valve replacement
Post MI |
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