Term
antimetabolites, bleomycin, microtubule inhibitors, etoposide |
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Definition
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Term
alkylating agents, antibiotics, sterod agonists/antagonists, cisplatin |
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Definition
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Term
nausea/ vomiting, stomatitis, alopecia, myelosupression |
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Definition
AE chemotherapeutic drugs |
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Term
Doxorubicin, Taxol toxicity |
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Definition
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Term
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Definition
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Term
cyclophosphamide toxicity |
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Definition
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Term
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Definition
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Term
vincristine, cytarabine toxicity |
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Definition
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Term
extravasation, nausea vomiting, hypersensitivity, diarrhea |
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Definition
acute chemotherapy toxicities |
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Term
myelosupression, alopecia, stomatitis, GI toxicity, diarrhea |
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Definition
delayed chemotherapy toxicities |
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Term
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Definition
compete with natural substrate for active site on enzyme or receptor, interfere/inhibit the synthesis of essential cellular elements. CCS |
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Term
Methotrexate (mexate, folex) |
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Definition
anticancer, antimetabolite- inhibits dihydrofolate reductase. high doses curative for esteogenic sarcoma and choriocarcinoma + lecovorin rescue. AE= BMS, NVD, stomatitis, urticaria, alopecia, crystalluria, renal/hepatic/pulmonary toxicity, learning disability in children, teratogenic |
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Term
Fluorouracil (5FU, adrucil) |
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Definition
anticancer,antimetabolite- inhibits thymidine synthesis- cell death. AE= hand-foot syndrome |
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Term
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Definition
anticancer,antimetabolite- 5-FU, thymidine starvation, tumor specific. oral |
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Term
6-mercaptopurine (purinethol) |
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Definition
anticancer, antimetabolite- purine analog, inhibition of purine synthesis= nonfxnl RNA/DNA |
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Term
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Definition
anticancer, antimetabolite- pyrimidine analog, inhibits DNA polymerase and retards chain elongation, neurotoxic |
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Term
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Definition
anticancer- antibiotic, anthracycline antiobiotic. CCS. intercalation of DNA, generation of oxygen radicals. P-glycoprotein resistance. AE cardiotoxicity |
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Term
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Definition
anticancer- antibiotic, CCS. DNA binding, oxygen radical formation and strand scission. P glycoprotein resistance. TX for testicular tumors. AE= pulmonary toxicity |
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Term
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Definition
anticancer- alkylating agent, CCNS. oral, p450 required for activation. AE= hemorrhagic systitis, secondary malignancies |
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Term
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Definition
anticancer, alkylating agent. AE- emesis,nephro/neuro/oto-toxicity, secondary malignancies |
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Term
Vincristine (oncovin, vcr) |
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Definition
anticancer, microtubule inhibitor- bind tubulin, block mitosis. CCS. P-glycoprotein resistance. AE= phlebitis, NVD, alopecia, mucositis, neurotoxic |
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Term
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Definition
anticancer, microtubule inhibitor- reversibly binds to tubulin, super rigidity. CCS, P-glycoprotein resistance. |
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Term
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Definition
anticancer, hormone- lymphocytopenic, action via nuclear transcription factors. AE= similar to glucocorticoids, ↑ appetite, cushing syndrome, puffy face, buffalo hump, cataracts |
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Term
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Definition
anticancer, hormone- SERM, binds to estrogen receptor but no effect, depletes estrogen receptors- not effective in premenopausal women. |
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Term
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Definition
anticancer, aromatase inhibitor- need hydrocortisone replacement; starve estrogen sensitive tumors |
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Term
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Definition
anticancer, aromatase inhibitor; starve estrogen sensitive tumors |
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Term
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Definition
anticancer, aromatase inhibitor- irreversible inhibitor; starve estrogen sensitive tumors |
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Term
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Definition
anticancer, hormone- gonadotropin release hormone analog, ↓ release of FSH, LH. TX prostatic cancer. |
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Term
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Definition
anticancer, monoclonal antibodies- antibody against human epidermal growth factor receptor protein 2 (HER2). inhibits proliferation of specific cancer cells. |
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Term
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Definition
anticancer, monoclonal antibodies- antibody against CD20--> B lymphocytes. |
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Term
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Definition
anticancer, monoclonal antibodies- Anti-VEGF (vascular endothelial growth factor)blocks growth of vascular tree |
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Term
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Definition
anticancer- blocks tumors access to asparagine. AE= hypersensitivity, hepatic dysfunction, seizures, coma, pancreatitis |
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Term
Interferon Alfa-2b (roferon-a) |
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Definition
anticancer- stimulates natural killer cells. TX hair cell leukemia |
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Term
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Definition
anticancer- topoisomerase I&II inhibitors, winds DNA up too tight and pops |
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Term
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Definition
anticancer- mTOR kinase inhibitors |
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