Term
|
Definition
An immunoglobin that binds a specific antigen. |
|
|
Term
|
Definition
|
|
Term
What is an Immune Complex? How is it held together? |
|
Definition
|
|
Term
Kaff (or simple affinity) measures: |
|
Definition
|
|
Term
Significance of Ag-Ab binding |
|
Definition
First step in host's defense function High affinity Abs are better in vivo for host defense. (they can quickly bind) May lead to tissue destruction/disease. (Vasculitis, Glumerulonephritis
|
|
|
Term
What are two common techniques used to test for antibodies? |
|
Definition
|
|
Term
How is antibody measurement as a diagnostic tool? |
|
Definition
Exposure to infectious agent (HIV, anthrax) Evidence of Immunity Certain autoimmune diseases Allergic reactions to substances Immunodeficiency Malignant Lymphoid diseases (Too much antibodies)
|
|
|
Term
Antibody dependent cellular cytotoxicity (ADCC) |
|
Definition
|
|
Term
How are the polypeptide chains of the Immunoglobins designated? |
|
Definition
|
|
Term
What is the neck region of the immunoglobin(Ig)? |
|
Definition
|
|
Term
What is the function of the different domains/regions of immunoglobins (Ig)? |
|
Definition
|
|
Term
What does Papain do to Immunoglobins? |
|
Definition
|
|
Term
What does Pepsin do to immunoglobins? |
|
Definition
|
|
Term
Hypervariable(HV) regions of immunoglobins: |
|
Definition
|
|
Term
What are the subclasses of IgA and IgG? |
|
Definition
|
|
Term
What determines the different classes of Immunoglobins? |
|
Definition
|
|
Term
What joins two imunoglobins? |
|
Definition
|
|
Term
How does IgM and IgA benefit from becoming multimers? |
|
Definition
|
|
Term
Which immunoglobin has the highest serum concentration and lasts the longest? |
|
Definition
|
|
Term
Which Immunoglobin is found binding to Mast cells? |
|
Definition
|
|
Term
Which Immunoglobin is involved in placenta transfers? |
|
Definition
|
|
Term
Which Human chromosomes code for immunoglobins? |
|
Definition
|
|
Term
|
Definition
|
|
Term
How are the gremline genes of the Light κ or λ chains organized? |
|
Definition
|
|
Term
How are the germine genes of the Heavy chain organized? |
|
Definition
Alot of V,J, and D(for Diversity) genes encode for the Variable domain. Single C gene codes for H chain class and subclass.
|
|
|
Term
What is the first Immunoglobin usually made? Where does it go? |
|
Definition
IgM (sometimes IgD, depending on alternative splicing) It hangs out on the surface of B-cells waiting to intereact with an antigen. |
|
|
Term
How many gene rearrangments must the Ig go through to produce a plasma cell? |
|
Definition
2 The first one makes IgM(or IgD) which sits on the surface of the mature B-cell. After contact with an antigen the Ig can change constant regions if needed. The B cell divides and activates into Plasma cells. |
|
|
Term
What is the first Ig to be secreted by the B cell? |
|
Definition
|
|
Term
What is the difference between Secreted Ig(sIg) and Membrane Ig(mIg) |
|
Definition
|
|
Term
Class switching or Isotype switch |
|
Definition
Going from Igm(or IgD) to IgG, IgA, IgE Involves second gene rearrangement/recombination event.
|
|
|
Term
|
Definition
|
|
Term
Clonal Selection theory and Basis of Specofoc Immunity |
|
Definition
|
|
Term
|
Definition
Each V,D, and J gene has many amino acid sequences. Any one of those sequences can be the last one transcribed and thus create even more diversity.
|
|
|
Term
Major Histocompatibility Complex (MHC) |
|
Definition
also called HLA (human leukocyte Antigens) Class I: All somatic. Controls CD8 T cells Class II: Controls CD4 cells Transplantation: control graft rejection.
|
|
|
Term
|
Definition
receptor for antigen binding by T cell. 2 types: αβ & γδ Gene rearrangement similiar to Ig Only binds Ag that is already attached to a MHC
|
|
|
Term
How does mutation affect TcR diversity? |
|
Definition
Unlike Igs, somatic mutation does not contribute to TcR diversity. |
|
|
Term
What are antibodies' effector functions in host defense? |
|
Definition
Neutralization of infectious agents or toxins Immune phagocytosis Complement activation Antibody dependent cellular cytotoxicity (ADCC) using NK cells Enhancement of Ag presentation, T cell activation & Immune reactivity.
|
|
|