Term
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Definition
Anti-viral (HSV, VZV)
MOA: inhibits viral DNA synthesis by competing with deoxyGTP for viral DNA polymerase; terminates chain elongation
Toxicity: severe renal dysfunction, neuro toxicity (IV) |
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Term
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Definition
Anti-viral (HSV, VZV)
MOA: inhibits viral fusion w/host cell |
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Term
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Definition
Anti-viral (CMV)
MOA: inhibits viral DNA polymerase
Toxicity: nephrotoxicity (use Probenecid to reduce) |
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Term
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Definition
Anti-viral (CMV)
MOA: inhibits viral DNA polymerase, terminates chain elongation
Toxicity: myelosupression, CNS toxicity, hepatotoxicity
Carcinogen at high doses |
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