Term
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Definition
Strep, Staph, Enterococci, Corynebacterium, Listeria |
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Term
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Definition
E. coli, salmonella, yersinia, Klebsiella, H. Flu, M. Cat, pseudomonas, Legionella |
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Term
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Definition
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Term
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Definition
Moraxella, Neisseria, E. coli, Klebsiella, Enerobacter, Salmonella, Psuedomonas, H. Flu |
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Term
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Definition
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Term
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Definition
Bacteroides, Fusobacterium |
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Term
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Definition
Pen, Ceph, Thienamycins, Monobactams |
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Term
Cell Wall non beta Lactam |
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Definition
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Term
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Definition
Aminoglycosides, Tetracyclins, Macrolides, Lincosamides |
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Term
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Definition
mostly by gastric acid, some duodenum |
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Term
Natural Pen: Active against? |
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Definition
Strep, Enterococcus, T. Pallidum, some anaerobic |
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Term
Natural Pen: Drug of choice? |
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Definition
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Term
Aminopen: Active against? |
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Definition
Strep, Entero (best), T. Pallidum, with gram neg (H. Flu, E. coli, K. pneumo) |
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Term
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Definition
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Term
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Definition
CSF, renal, joints, ascitic fluid |
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Term
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Definition
lung, ascitic fluid, pericardium, synovium, soft tissues |
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Term
Pen-Resisant PCNs: drugs? |
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Definition
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Term
Pen-Resistant: active against? |
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Definition
strep, staph (MSSA, best) |
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Term
Pen-Resistant: distribution? |
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Definition
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Term
Carboxypens: active against/ drug name? |
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Definition
Gram neg (pseudomonas) Ticarcillin |
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Term
Ureidopenicillin: active against/ drug name? |
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Definition
Gram neg (pseudomonas, bacteriodes), enterococcal, anaerobes
piperacillin |
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Term
B lactam inhibitors: active against? |
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Definition
H. Flu, M. cat, N. gonorr, B. Frag |
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Term
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Definition
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Term
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Definition
Amoxicillin/ clavulanic acid |
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Term
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Definition
Ticarcillin/ clavulanic acid |
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Term
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Definition
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Term
First Gen Ceph: Drug names? |
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Definition
cefazolin, cephalexin, cefadroxil |
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Term
First Gen ceph: Active against? |
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Definition
strep, MSSA (best)
NO ANAEROBIC COVERAGE |
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Term
Second Gen ceph: drug names? |
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Definition
group 1: cefuroxime, cefaclor group 2: cefoxitin, cefotetan
GROUP 2= MTT CHAIN |
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Term
Second Gen ceph: active against? |
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Definition
group 1= strep, MSSA, some gram neg group 2= less strep and MSSA, even more gram neg, and B. Frag |
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Term
Second Gen ceph: distribution? |
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Definition
group 1= respiratory, CSF group 2= dirty surgery |
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Term
Third Gen ceph: drug names? |
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Definition
ceftazidime, ceftriaxone, others |
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Term
Third Gen ceph: active against? |
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Definition
ceftazidime = anti pseudomonal Ceftriaxone = meningitis (CSF), lyme |
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Term
Fourth Gen ceph: drug name? |
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Definition
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Term
Fourth Gen ceph:active against? |
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Definition
staph and strep. increased gram negative activity (pseudomonas), CSF
most people aren't this sick |
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Term
Fifth Gen ceph: drug names/active against? |
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Definition
Ceftaroline: everything, MRSA Ceftobiprole: MRSA |
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Term
Thienamycins (Penems): drug names? |
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Definition
imipenem (with cliastatin), ertapenem, meropenem |
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Term
Theienamycins (Penems): active against? |
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Definition
most gram posistive aerobes, and almost all gram negative aerobes (except s. maltophilia) and anaerobes |
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Term
Theienamycins (Penems): facts |
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Definition
cell wall active, post antibiotic effect, extremely broad spectrum |
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Term
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Definition
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Term
Monobactams: active against? |
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Definition
gram neg aerobic
NO GRAM POS |
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Term
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Definition
gentamicin, tobramycin, amikacin, streptomycin |
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Term
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Definition
bind to 30s and 50s binding sites |
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Term
Aminoglycosides: normal activity? |
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Definition
gram neg aerobes (Pseudomonas)
NO ANAEROBIC OR GRAM POS |
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Term
Aminoglycosides: synergistic activity? |
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Definition
synergistic with cell wall drugs for MSSA, MRSA, enterococcus, and pseudomonas |
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Term
Aminoglycosides: distribution? |
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Definition
Urine, most tissues, no csf |
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Term
Aminoglycosides: adverse events? |
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Definition
Nephrotoxic (can be reversible), ototoxic (cochlear, nonreversibe) (vestibular, can be reversible), and neuromuscular block |
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Term
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Definition
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Term
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Definition
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Term
Tetracyclines: adverse events? |
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Definition
avaoid in hepatic/ renal impairment, phototoxic, gray brown teeth, can't drink milk with it |
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Term
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Definition
GP and GN aerobes. atypical pathogens of pneumonia |
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Term
Tetracycline: distribution? |
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Definition
Maxillary sinus mucosa, bile, lung, etc. |
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Term
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Definition
erythromycin, clarithro, azithro |
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Term
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Definition
GP and GN aerobes. atypical pathogens of pneumonia |
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Term
Macrolides: adverse events? |
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Definition
GI intolerance, thrombophlebitis, tinnitis |
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Term
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Definition
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Term
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Definition
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Term
Lincosamides: distibution? |
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Definition
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Term
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Definition
MSSA, strep, GN anaerobes (B.frag), GP anaerobes, toxoplasmosis |
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Term
Lincosamides: adverse events? |
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Definition
GI intolerance to c. dif, pseudomembranous colitis |
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Term
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Definition
cirprofloxacin, norfloxacin, levo, moxi |
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Term
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Definition
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Term
Fluroquinolones: activity? |
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Definition
GN aerobes (pseudomonas), some GP aerobes (MSSA, strep), atypical pathogens of pnemonia |
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Term
Fluroquinolones: distribution? |
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Definition
repiratory (moxi, levo), non respiratory (cipro), UTI (norflox), bone |
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Term
Fluroquinolones:adverse events? |
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Definition
chelation, QT prolongation, photoxicity |
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Term
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Definition
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Term
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Definition
cell wall, beta lactam stable |
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Term
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Definition
oral used to tx c.dif is not systemically absorbed.
also, need troughs |
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Term
Glycopeptides: adverse events? |
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Definition
Red man's syndrome, ototoxicity, nephrotoxicity |
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Term
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Definition
strep, staph, MSSA, MSSE, MRSE, enterococcal. c.dif is only anaerobe |
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Term
Glycopeptides: distribution? |
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Definition
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Term
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Definition
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Term
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Definition
inhibits bacterial folic acid synthesis, which doesn't allow bacteria to grow |
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Term
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Definition
need to hydrate or crystalluria will form, increases anticoagulation for warfarin, avoid in hemodialysis, SJS, elevated serum CR |
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Term
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Definition
GN and GP aerobes (but no psuedomonas, group A strep, or enerococcus), very active against P. carinii |
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Term
Nitroimidazoles: drug name? |
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Definition
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Term
Nitroimidazoles: Metronidazole, activity? |
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Definition
covers all anaerobes, including c.dif and h. pylori |
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Term
Nitroimidazoles: Metronidazole, MOA? |
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Definition
reduces toxic intermediates (free radicals) which damage DNA |
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Term
Nitroimidazoles: Metronidazole, adverse events? |
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Definition
Disulfiram cannot be mixed with any alcohol, dark urine, rash |
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Term
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Definition
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Term
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Definition
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Term
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Definition
gram positive, enerococci, all staphs, all streps |
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Term
oxalinediones: distribution? |
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Definition
invitro against many organisms
no dose adjustment |
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Term
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Definition
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Term
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Definition
bind to cell membrane causing rapid depolarization, leading to inhibition of proteins, and death |
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Term
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Definition
gram positive, strep, entero, s. aureus
first drug bacteriocidal against gram pos |
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