Term
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Definition
| inhibits Topo II and thus stops DNA transcription since DNA becomes too positively supercoiled; bacteriocidal |
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Term
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Definition
| inhibits Topo II and thus stops DNA transcription since DNA becomes too positively supercoiled |
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Term
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Definition
| inhibits Topo II and thus stops DNA transcription since DNA becomes too positively supercoiled |
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Term
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Definition
| inhibits dNTP synthesis by inhibiting dihydrofolate reductase thus reducing the tetrahydrofolate pool |
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Term
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Definition
| PABA analog and so inhibits folic acid synthesis; used in conjunction with trimethoprim; used to treat Nocardia infection |
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Term
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Definition
| β-lactam antibiotic; D-ala-D-ala analog; targets cell wall synthesis by inhibiting peptidoglycan cross-linking (transpeptidation) outside the bacterium; bacteriocidal |
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Term
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Definition
| inhibits incorporation of NAG and NAM subunits into growing peptidoglycan chain by binding to d-alanine-d-alanyl side chain (inhibits transglycosylase); also inhibits transpeptidation (transpeptidase); ONLY for gram positive bacteria; bacteriocidal |
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Term
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Definition
| inhibits recylcing of BPP (lipid carrier) which carries subunits of bacterial cell wall through cellular membrane to periplasm by inhibiting dephosphorylation and so BP can't pick up the subunits |
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Term
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Definition
| analog of PEP; acts as mimic of substrate for enzyme reaction from NAG to NAM synthesis and so blocks cell wall synthesis; works in cytosol |
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Term
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Definition
| mimics shape of D-alanine and so competes with enzyme alanine racemase which converts L-alanine to D-alanine and competes for D-ala-D-ala synthetase which makes the D-ala-D-ala subunit of the peptidoglycan chain; works in the cytosol |
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Term
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Definition
| inhibits cell wall synthesis by targeting mycolic acid; used for TB |
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Term
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Definition
| inhibits cell wall synthesis; used for TB |
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Term
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Definition
| inhibits fatty acid synthesis; used for TB |
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Term
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Definition
| inhibits 50S ribosomal subunit; bacteriostatic; NOT used in combo with bacteriocidal drugs; useful in meningitis because accumulates in CSF |
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Term
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Definition
| inhibits folate synthesis; used for TB |
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Term
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Definition
| inhibits protein synthesis; used for TB |
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Term
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Definition
| inhibits protein synthesis; used for TB |
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Term
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Definition
| RNA polymerase inhibitor; used for Mycobacterium leprae infection; can be used for TB treatment; prophylactic treatment for meningitis |
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Term
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Definition
| β-lactam antibiotic; inhibits transpeptidation |
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Term
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Definition
| β-lactam antibiotic; inhibits transpeptidation |
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Term
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Definition
| β-lactam antibiotic; inhibits transpeptidation |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
| 1st generation cephalosporin; β-lactam antibiotic |
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Term
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Definition
| 2nd generation cephalosporin; β-lactam antibiotic |
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Term
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Definition
| 3rd generation cephalosporin; β-lactam antibiotic |
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Term
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Definition
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Term
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Definition
| β-lactamase inhibitor; comibined with penicillin or other penicillin derivatives |
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Term
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Definition
| β-lactamase inhibitor; comibined with penicillin or other penicillin derivatives |
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Term
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Definition
| β-lactamase inhibitor; comibined with penicillin or other penicillin derivatives |
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Term
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Definition
| antibiotic targeting membranes by altering structure and making it more permeable thus causing lysis due to osmotic pressure; used for resistant gram negative bacteria; problem because eukaryotic cells also have membranes |
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Term
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Definition
| aminoglycoside antibiotic; inhibits 30S ribosomal subunit (inhibits protein synthesis); extremely bacteriocidal once in cell (not reversible); low therapeutic value; used for TB treatment; bacteriocidal |
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Term
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Definition
| aminocyclotol antibiotic; inhibits 30S ribosomal subunit (inhibits protein synthesis) |
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Term
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Definition
| inhibits 30S ribosomal subunit; effective only against rapidly dividing cells; used to treat INTRACELLULAR bacterial infections; bacteriostatic |
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Term
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Definition
| tetracycline antibiotic that targets 30S ribosomal subunit; bacteriostatic |
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Term
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Definition
| vancomycin; penicillins; cephalosporins; ciproflaxin; streptomycin (aminoglycosides) |
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Term
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Definition
| sulphonamides; tetracyclines; chloramphenicol; lincamycin; clindamycin |
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Term
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Definition
| macrolide; inhibits 50S ribosomal subunit |
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Term
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Definition
| macrolide; inhibits 50S ribosomal subunit; broader spectrum than erythomycin |
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Term
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Definition
| lincosamide antibiotic; inhibits the 50S ribosomal subunit |
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Term
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Definition
| Topo II (Gyrase) inhibitor |
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Term
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Definition
| Topo II (Gyrase) inhibitor |
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Term
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Definition
| prevents formation of fmet-tRNA:mRNA:30S subunit ternary complex, preventing initiation of translation (protein synthesis) |
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Term
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Definition
| combo of Quinupristin (competes with macrolides for 50S binding) and Dalfopristin (binds to 50S ribosomal unit and prevents elongation) |
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Term
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Definition
| target is bacterial membrane; used for skin infections; used for gram positive aerobes that are resistant to other antibiotics |
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Term
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Definition
| targets plasma membrane; maybe problem because our cells also have plasma membranes |
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Term
| inhibitors of the 30S ribosomal subunit |
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Definition
| aminoglycosides (streptomycin) and tetracyclines (tetracycline & doxycycline) |
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Term
| inhibitors of 50S ribosomal subunit |
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Definition
| chloramphenicol, macrolides (erythromycin & azithromycin) and linosamide (clindamycin) |
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