Term
|
Definition
Aminoglycoside: 30S cidal (translation defects) concentration dependant
r = enzymatic inactivation/mutated binding site
GRAM + and GRAM - ONLY (transport via high membrane potential so no anerobe)
JUST RENAL (no cns): typically systemic infection gram - rods
1. NEPHRO and OTOtoxic
2. contraindicated myastinia gravis
inhibits formation initiation complex |
|
|
Term
|
Definition
Binds 50S peptidyl transferase elongation
r - enzymatic deactivation
GM -, intracellular, anerobic
GOOD CNS; GREY BABY SYNDROME
1. hemolysis, 2. aplastic anemia, 3.BM supression
use as alternative to tetracyclins for ricketsia infections |
|
|
Term
|
Definition
Licosamides: 50 S movement from P to A (very end)elongation
r = methylation ribosome
gm +/ anerobes --> REALLY ANEROBIC USE
good distribution POOR CNS
1. CAUSES C-DIFF
2. Horrible diahrea
3. thrombocytopenia
REALLY USED ALTERNATIVE MRSA |
|
|
Term
| Azithromycin, Telithromycin |
|
Definition
Macrolide inhibits translocation
r - enzymatic methylation
gram +/grm -/intracellular...usually used for weird intracellular/mycoplasm
poor cns
MYCOPLASMA/CHLYMIDIA
1. motilin = GI distress
2. toxic arrythmias |
|
|
Term
|
Definition
Oxazolinones: prevents initiaztion 70S complex... P 50S site.
NARROW GRM + ONLY
1. neutropenia/neuropathy
2. AVOID SSRI!!!!!
GOOD CND, RESERVE RESESITANT MRSA VREC |
|
|
Term
| Quinupristin/Daltopristin |
|
Definition
streptogramin: Dalto helps Quinu bind...both inhibit elong/trans @ 50S
GM + ONLY --> Skin infections with MRSA...some injection irritation |
|
|
Term
|
Definition
tetracyclins: Block (30S) A site entry of tRNA... STATIC and BROAD (elong)
r = DISPLACEMENT PROTEIN + efflux (TIGECYCLIN BETTER)
2nd line
gm +/- and INTRACELL and SPIRO
(BEST LYME/RICKETSIA DISEASE)
TIGE = last resort for MRSA (poor cns)
chelated by Fe and oral antacids
1. gi distress
2. photosensitivity
3. DISCOLORED BONE/TEETH |
|
|
Term
| 30S vs 70S subunit antibiotics |
|
Definition
30 = aminoglycosides/tetracyclines
50 = macrolides, chloramphen, lincosamides, streptogramins, linezolid |
|
|
Term
| protein antibiotics that interact |
|
Definition
| chloramphen, macrolides, clindamycin all bind next to eachother on 50S and therefore may reduce additive effects |
|
|
