Term
| inhibitors of RNA polymerase? |
|
Definition
|
|
Term
| side effects of Rifampin? |
|
Definition
| induces P450 enzymes, orange body fluids. |
|
|
Term
| indications for Rifampin? |
|
Definition
|
|
Term
| indications for Clofazimine? |
|
Definition
|
|
Term
| Topoisomerase II and IV inhibitor? |
|
Definition
|
|
Term
| side effects of Fluoroquinolones? |
|
Definition
| cartilage function and prolong QTc |
|
|
Term
| when do you use fluoroquinolones? |
|
Definition
| reserved for serious infections and heavily resistant bugs |
|
|
Term
| drug that blocks DNA synthesis? |
|
Definition
|
|
Term
| Inhibits a.a. tRNA synthetase? |
|
Definition
| Linezolid (inhibits formation of fMET tRNA) and Mupirocin (gram+, MRSA, VREF, 50S subunit) |
|
|
Term
| Inhibitors of Initiation complex? |
|
Definition
| aminglycosides (30S subunit, gram-, endocarditis, "ear-reversible" toxicity) and tetracyclines (acne, lyme, bone chelation, phototoxicity) |
|
|
Term
| inhibitors of peptide bond formation and elongation? |
|
Definition
| chloramphenicol (peptidyl synthetase), clindamycin (dissociates tRNA from ribosome, gram+) and macrolides (pseudomembranous colitis) |
|
|
Term
| what suffix do all fluoroquinolones have in common? |
|
Definition
| "-floxacin" (cipro-, nor-,o-,levo-) |
|
|
Term
| what does erythromycin inhibit? |
|
Definition
| translocase (movement of growing peptide from A to P site in ribosome) |
|
|
Term
| major side effect of erythromycin? |
|
Definition
| potentiation of other drugs (blocks P450 enzymes) |
|
|
Term
| what is the 1/2 life of azithromycin? |
|
Definition
|
|
Term
| what is another macrolide P450 inhibtor (aside from erythromycin)? |
|
Definition
|
|
Term
| Quinipristin and Dalfopristin (synercid) bind on which ribosomal subunit? |
|
Definition
| 50s, just like the macrolides |
|
|
Term
| does synercid treat VREF ? |
|
Definition
|
|
Term
| what are the 4 goals of TB treatment? |
|
Definition
| 1) eradicate disease entirely, 2) allow no emergence of resistant strains, 3) minimize drug toxicity, 4) investigate all possible contact; its a social disease |
|
|
Term
| what are the 1st line group of drugs for TB treatment? |
|
Definition
| isoniazid + rifampin (and ethambutol and pyrazinamide) |
|
|
Term
| how is the metabolism of isoniazid different between people? |
|
Definition
| its metabolism is genetically controlled |
|
|
Term
| what drug is common to all 4 types of leprosy treatment? |
|
Definition
|
|
Term
| what is the history of thalidomide? |
|
Definition
| 1960s, a single tablet taken during 1st trimester of pregnancy caused caused congenital abnormalities. |
|
|
Term
| is the Dapsone 1/2 life long or short? what is it used for? |
|
Definition
| long. used for folic acid synthesis (blocks that PABA thing) |
|
|
Term
| what is one of the most important ways of avoiding resistance? |
|
Definition
|
|
Term
| what causes Grey Baby Syndrome? |
|
Definition
|
|
Term
| What causes Red Man Syndrome? |
|
Definition
|
|
Term
| what causes Steven Johnson Syndrome? |
|
Definition
| Sulfamethoxazole + Trimethoprim |
|
|
Term
|
Definition
| Sulfamethoxazole + Trimethoprim |
|
|
