Term
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Definition
Flouroquinolones: BROAD SPECTRUM BACTERIALCIDAL GYRASE (gram - topoisomerase inhibitor)
mostly gram - and intracellular
resistance = change topoisomerase
Respiratory, UTI, prostatits (poor cns)
conjunctivitis
1. prolongs QT interval
2. neuromuscular junction block
3. epilepsy threshold lowered
4. TENDINOPATHY!!!!! |
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Term
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Definition
Respiratory Flouroquinolones: broad Bacterialcidal topoisomerase inhibitor
mostly gram negitive and intracellular
Gram + = strep pneumo
resistance = change topoisomerase
Respiratory, UTI, prostatits (poor cns)
1. prolongs QT interval
2. neuromuscular junction block
3. epilepsy threshold lowered
5. TENDINOPATHY!!! |
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Term
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Definition
ANEROBIC BACTERIALCIDE: can enter CNS
resistance = altered nitroreductase
peptic ulcer, wound, clost diff.
1. lowers alcohol dehydrogenase
2. darkens urine
3. periphral neuropathy |
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Term
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Definition
Sulfonamide: competitive dihydropteroate syntase inhibitor (THF/nucleoside synthesis)
BROAD BACTERIOSTATIC, CNS
GM +/- and intracellular
r = increased paba or mutated dhpt
CONTRAINDICATED PREGNANCY
1. steven johnson syndrome
2. hemolytic anemia
use uti/pneumocystis, community MRSA |
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Term
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Definition
Dihydrofolate reductase inhibitor
r= mutated THFR, good urine/CNS
Gm +/- and intracellular
CONTRAINDICATED FOLATE ANEMIA
UTI/PNEUMOCYST/community MRSA |
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