Term
| Flouroquinolones don't work on... |
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Definition
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Term
| Macrolides don't work on... |
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Definition
| Gram negative organisms (aerobic and anaerobic) |
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Term
| Metronidazole doesn't work on.... |
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Definition
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Term
| Aminoglycosides don't work on... |
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Definition
| Gram positives (all) or Gram negative anaerobes. |
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Term
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Definition
Penicillins, cephalosporins.
Inhibit cell wall synthesis by binding to penicillin binding proteins (PBP).
Resistance by production of beta-lactamases by bacterial cells.
Effective against most bacteria w/o beta-lactamase- broad spectrum. |
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Term
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Definition
Inhibit protein synthesis, affects host cell proteins mildly also.
Resistance via plasmids for efflux pumps w/ cross-resistance.
Names ending in -cycline.
Broad spectrum. |
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Term
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Definition
Inhibits protein synthesis.
Plasmid mediated resistance.
Broad spectrum efficacy. |
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Term
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Definition
Inhibit protein synthesis.
REQUIRE O2-DEPENDENT ACTIVE TRANSPORT- no effect on anaerobes!
Incomplete cross resistance due to plasmid mediated enzymes (specific for different drugs in the class). |
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Term
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Definition
Inhibit protein synthesis.
Drugs ending in -mycin.
Not active against gram negatives. |
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Term
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Definition
Inhibit protein synthesis.
Also ending in -mycin (clindamycin in vet med).
Effective for Mycoplasma, Gram + aerobes and anaerobes. |
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Term
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Definition
Target DNA recoiling by disabling topoisomerases.
Don't work for anaerobes.
Resistance by new plasmid, DNA enzyme changes, or conjugation.
Names of drugs with -floxacin. |
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Term
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Definition
Block step in folic acid pathway.
With trimethoprim/ormetoprim- bacteriocidal by blocking a 2nd step.
Cross resistance by plasmid with new enzyme or producing more enzyme. |
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Term
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Definition
| Bacteriocidal against obligate anaerobes. |
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