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Antibacterial drugs
antibacterial drugs
35
Microbiology
Professional
02/20/2011

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Term
Penicillin
Definition
PBP-crosslinking of petidoglycan
-inhibit cell wall synthesis
Term
methicillin
Definition
PBP-crosslinking of petidoglycan
-inhibit cell wall synthesis
-penicillinase-resistant
Term
naficillin
Definition
PBP-crosslinking of petidoglycan
-inhibit cell wall synthesis
-penicillinase-resistant
Term
ampicililn
Definition
PBP-crosslinking of petidoglycan
-inhibit cell wall synthesis
-broad spectrum
Term
amoxicillin
Definition
PBP-crosslinking of petidoglycan
-inhibit cell wall synthesis
-broad spectrum
Term
cephalosporin
Definition
PBP-crosslinking of petidoglycan
-inhibit cell wall synthesis
-resistant to beta-lactamases
-"cef"
Term
cephamycin
Definition
PBP-crosslinking of petidoglycan
-inhibit cell wall synthesis
-resistant to beta-lactamases
-"cef"
Term
bacitracin
Definition
-peptidoglycan precursor
-inhibit cell wall synthesis
Term
polymyxin
Definition
-outer membrane of gram (-)-LPS
Term
Vancomycin
Definition
D-ala-D-ala peptidoglycan subsitute
-disrupts peptidoglycan by preventing the incorportation of NAG and NAM
-IV
Term
Daptomycin
Definition
-inhibits cell membrane-only gram (+)
Term
Isoniazid
Definition
inhibits synthesis of mycolic acid->main player in TB
Term
ethionamide
Definition
-inhibits synthesis of mycolic acid-TB
Term
ethambutol
Definition
-inhibits arabinogalactan synthesis in cell wall-TB
Term
quinolone
Definition
-bacterial topoisomerase II and IV
-both gram (+) and gram (-)
-inhibits DNA replication
Term
floroquinolone
Definition
-bacterial topoisomerase II and IV
-both gram (+) and gram (-)
-inhibits DNA replication
Term
metronidazole
Definition
-inhibits DNA synthesis
-anaerobic bacteria
Term
clofazimine
Definition
-guanine base analog->blocks DNA
-TB and Leprosy
Term
rifampin
Definition
DNA-dependent RNA polymerase
-TB
-orange secretions
Term
sulfonaminde
Definition
inhibit folic acid synthesis-dihydropteroate synthetase
Term
trimethoprim
Definition
inhibit folic acid synthesis-DHF reductase
Term
dapsone
Definition
inhibit folic acid synthesis--competitive inhibitor of dihydropteroate synthase
-used with rifampin and clofazimine to treat leprosy
Term
aminoglycoside
Definition
30S ribosome
-gram (-)
Term
streptomycin
Definition
30S ribosome
-gram (-)
Term
tetracycline
Definition
30S ribosome
-broad spectrum
Term
doxycycline
Definition
30S ribosome
-broad spectrum
Term
linezolid
Definition
50S ribosome
-oxazolidinone
Term
chloramphenical
Definition
50S ribosome
-interupts with done marrow protient synthesis->aplastic anemia
Term
macrolide
Definition
50S ribosome
Term
erythromycin
Definition
50S ribosome
macrolide
Term
azithromycin
Definition
50S ribosome
macrolide
Term
ketolide
Definition
50S ribosome
telithromycin-derivative of erthromycin
Term
telithromycin
Definition
50S ribosome
-ketolide
Term
clindamycin
Definition
50S ribosome
Term
streptogramin
Definition
50S ribosome
-quinupristin-dalfopristan given back to back
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