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beta blocker and potassium channel blocker |
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potassium channel blocker |
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pulseless VT/VF wide complex tachycardia (a-fib) |
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-prolongs myocardial cell action potential -prolongs refractory period -K and Na channel blocking -reduces automaticity of SA node -reduces contractility and conduction velocity in AV node, ventricles, bundle of His, and Purkinje system |
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amiodarone adverse effects |
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thyroid abnormalities (from iodine) pulmonary fibrosis corneal deposits
grey/blue discoloration of skin CNS/GI disturbance pro-arrhythmic effects heart block nightmares abnormal LFT |
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amiodarone drug interactions |
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calcium channel blocker side effects |
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alternative to amiodarone |
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Na-K ATPase inhibition positive inotrope vagomimetic |
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drug interactions with digoxin |
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coumadin (inc. PT/INR) quinidine, amiodarone, verapamil (inc. dig level) spironolactone (dec. renal function) |
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dig toxicity clinical manefestation |
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combo of SVT and AV block
yellow-green vision |
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What predisposes someone to dig toxicity? |
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How do you counteract a digoxin toxicity? |
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Digibind (digoxin-specific Fab fragment |
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