Term
| CLASS 1B HAS GREATER AFFINITY FOR NA CHANNELS WHEN? WHAT DOES THAT RESULT IN? |
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Definition
| IN THE INACTIVE STATE. RESULTS IN FASTER RECOVERY R/T DISSOCIATE EASIER. |
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Term
| WHAT IS THE MAIN DRUG IN CLASS 1B ANTIARRYTHMICS? |
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Definition
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Term
| WHAT TYPE OF FIRST PASS EFFECT DOES LIDOCAINE HAVE? |
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Definition
| EXTENSIVE!!! THAT IS WHY THERE IS NO PO DOSING. |
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Term
| HOW IS LIDOCAINE INACTIVATED? |
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Definition
| RAPIDLY BY HEPATIC ENZYMES. HALF LIKE IS 1-2 HRS. |
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Term
| WHAT IS THE DRUG OF CHOICE FOR TERMINATING VENTRICULAR ARRHYTHMIAS, ESPECIALLY AFTER ACUTE ISCHEMIA (MI)? |
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Definition
| LIDOCAINE. BLOCKS ISCHEMIC TISSUE BETTER THAN HEALTHY TISSUE. |
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Term
| IS LIDOCAINE EFFECTIVE FOR SUPRAVENTRICULAR ARRHYTHMIAS? |
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Definition
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Term
| HOW DOES LIDOCAINE SHORTEN REPOLARIZATION? |
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Definition
| BLOCKING THE SODIUM CHANNELS THAT INACTIVATE LATE DURING PHASE 2, SO DOES NOT PROLONG QTI. |
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Term
| WHAT CAN INCREASE THE RISK OF LIDOCAINE TOXICITY? |
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Definition
| COMPETETION AT CYP450 ENZYMES CAN INCRESE THE RISK OF TOXICITY. |
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Term
| WHAT IS THE DOSE OF LIDOCAINE? |
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Definition
| 1.5-2MG/KG IV BOLUS OVER 15 MINUTES, FOLLOWED BY AN INFUSION OF 2-4MG/MIN. |
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Term
| WHEN DO YOU REDUCE THE INFUSION DOSE OF LIDOCAINE? 2 ANSWERS |
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Definition
| REDUCE BY 50% IF POOR CARDIAC OUTPUT OR REDUCED HEPATIC BLOOD FLOW. (CHF OR HF; HIGH H.E.R. DRUG RESULTS IN VERY PERFUSION DEPENDENT; ANESTHESIA ALS DECREASES HEPATIC BLOOD FLOW. |
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Term
| WHAT IS THE ONSET AND DURATION OF LIDOCAINE? |
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Definition
| ONSET IS 1-2 MINUTES AND DURATION IS 20 MINUTES FOR IV ADMINISTRATION. |
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Term
| AT PLASMA LEVELS OF ___ LIDOCAINE HAS FEW SIDE EFFECTS. |
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Definition
| 5MCG/ML OR LESS (MORE ANALGESIC AND ANTIARRHYTHMIC) |
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Term
| AT PLASMA LEVELS OF ____ WHAT KIND OF EFFECTS DO YOU SEE? |
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Definition
| AT PLASMA LEVELS OF 5-10MCG/ML, CNS EFFECTS INCLUDE TINNITUS NERVOUSNESS, TREMORS, CIRCUMORAL NUMBNESS, AND PERIPHERAL VASODILATION AND MYOCARDIAL DEPRESSION OCCUR. |
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Term
| AT PLASMA LEVELS ____ WHAT HAPPENS? |
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Definition
| AT PLASMA LEVELS EXCEED 10MCG/ML, SEIZURES, APNEA, AND CARDIAC ARREST OCCURS. |
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Term
| SEIZURE THRESHOLD FOR LA TOXICITY IS DECREASED BY WHAT 3 THINGS? |
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Definition
| HYPOXEMIA, HYPERKALEMIA, AND ACIDOSIS. ACIDOSIS INCREASES CNS VASODILATION AND INCREASE CO2 DELIVERY. |
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Term
| WHAT IS THE TREATMENT FOR HIGH PLASMA LEVELS? |
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Definition
| HYPERVENTILATE WHICH DECREASES HYPOXEMIA AND ACIDOSIS AND GIVE O2. |
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Term
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Definition
| MUCH LIKE CLASS 1A BINDS TO OPEN STATE NA CHANNELS; VERY SLOW RECOVERY |
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Term
| WHAT CLASS OF DRUGS ARE THE MOST POTENT BLOCKERS OF THE FAST DOSIUM CHANNELS, WITH LITTLE EFFECT ON THE DURATION OF THE ACTION POTENTIAL? |
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Definition
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Term
| IN THE VENTRICULAR MYOCYTE CLASS 1C DOES WHAT? |
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Definition
| SIGNIFICANTLY DECREASE THE RATE OF UPSTROKE IN PHASE 0. |
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Term
| WHT ARE 3 EKG EFFECTS OF CLASS 1C? |
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Definition
| PROLONGS PR INTERVAL, QRS, AND SOME QTI PROLONGATION |
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Term
| WHAT ARE THE 2 CLASS 1C DRUGS? |
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Definition
| FLECAINIDE AND PROPAFENONE |
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Term
| HOW IS FLECAINIDE TAKEN AND WHAT IS IT USED TO TREAT? |
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Definition
| ORALLY AND USED TO TREAT SVT AND VENTRICULAR ARRHYTHMIAS. |
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Term
| FOR FLECAINIDE WHEN DOES MORTALITIY INCREASE? |
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Definition
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Term
| WHAT 3 THINGS DOES FLECAINIDE CAUSE? |
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Definition
| SEIZURE, THROMBOCYTOPENIA AND BRONCHOSPASM |
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Term
| HOW IS PROPAFENON GIVEN AND FOR WHAT FOR? |
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Definition
| ORALLY FOR SVT, AFIBB, VT |
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Term
| WHAT KIND OF ADVERSE EFFECTS DOES PROPAFENONE HAVE? |
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Definition
| SIMILAR TO FLECAINIDE WHICH INCLUDE BRONCHOSPASM, SEIZURES, AND THROMBOCYTOPENIA. THIS IS NOT THE MOST DESIRABLE DURG OUT THERE. |
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