Term
| WHAT DRUGS WORK ON CLASS 1 ANTIARRHYTHMICS? |
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Definition
| NA CHANNEL BLOCKERS (OPEN DURING UPSTROKE, INACTIVE DURING PLATEAU, CLOSED FOR REPOLARIZATION). |
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Term
| HOW DO SODIUM CHANNEL BLOCKERS WORK? |
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Definition
| BIND TO SODIUM CHANNELS IN THE OPEN OR INACTIVATED STATE, THEN DISSOCIATE DURING THE RESTING (CLOSED) STATE. |
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Term
| WHAT IS USE-DEPENDENT BLOCKADE? |
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Definition
| FREQUENCY OF USE INCREASES TIME SPENT IN OPEN OR INACTIVE STATE; DECREASES THE RESTING TIME. |
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Term
| FOR SODIUM CHANNEL BLOCKERS WHAT RESULTS WITH TACHYCARDIA? |
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Definition
| INCREASE IN OPEN CHANNELS AND INCREASE USE OF NA CHANNELS. |
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Term
| IN THE SA NODE, CLASS 1 ANTIARRHYTHMICS DECREASE THE RATE OF FIRING BY WHAT 2 MECHANISMS? |
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Definition
| INCREASES THRESHOLD AND DECREASES THE SLOPE OF PHASE 4. THESE ARE SAME AS PNS EFFECTS!!! |
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Term
| HOW MANY CLASSES OF 1 DRUGS ARE THERE? |
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Definition
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Term
| WHICH CLASS HAS THE GREATER AFFINITY FOR OPEN STATE OF SODIUM CHANNEL AND RESULTS IN SLOW RECOVERY? |
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Definition
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Term
| CLASS 1A ALSO BLOCKS WHAT? |
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Definition
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Term
| IN THE VENTRICULAR MYOCYTE WHAT DOES CLASS 1A DRUGS DO? |
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Definition
| SLOWS THE RATE OF PHASE 0 DEPOLARIZATION (SLOWED DEPOLARIZATION) AND SLOWS THE RATE OF PHASE 3 REPOLARIZATION (PROLONGED ACTION POTENTIAL AND REFRACTORY PERIOD). |
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Term
| WHAT ARE 2 EKG EFFECTS OF CLASS 1A DRUGS? |
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Definition
| PROLONGED QRS AND PROLONGED QT-INTERVAL. |
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Term
| WHAT ARE THE 3 DRUGS FOR CLASS 1A? |
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Definition
| QUINIDINE, PROCAINAMIDE, ANDDISOPYRAMIDE. |
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Term
| WHICH DRUG IS QUINIDINE SIMILAR TO AND HOW DOES IT WORK? |
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Definition
| ATROPINE. IS EXERTS AN ANTICHOLINERGIC EFFECT WHICH CAN INCREASE CONDUCTION VELOCITY THROUGH SA AND AV NODE. |
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Term
| THE USE OF QUINIDINE IS UNCOMMON DO TO 2 MAIN SIDE EFFECTS. WHAT ARE THEY? |
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Definition
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Term
| HOW IS QUINIDINE METABOLIZED? |
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Definition
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Term
| WHAT ARRYTHMIA CAN QUINIDINE INCREASE THE RISK OF? |
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Definition
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Term
| WHAT KIND OF LEVELS CAN QUINIDINE INCREASE? |
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Definition
| DIG LEVELS AMIODARINE AND VERAPAMIL ALSO WORK THIS WAY. |
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Term
| PROCAINAMIDE IS A DERIVATIVE OF WHAT? |
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Definition
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Term
| HOW IS PROCAINAMIDE METABOLIZED? |
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Definition
| BY THE LIVER TO AN ACTIVE METABOLITE |
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Term
| WHAT DOES LONG TERM USE CAUSES? |
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Definition
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Term
| WHAT KIND OF ANTICHOLINERGIC EFFECTS DOES PROCAINAMIDE HAVE AND DOES IS ALTER DIG LEVELS? |
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Definition
| FEW ANTICHOLINERGIC EFFECTS AND DOES NOT ALTER DIG LEVELS. |
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Term
| WHAT IS UNIQUE ABOUT DISOPYRAMIDE? |
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Definition
| IT HAS MORE ANTICHOLINERGIC (BLOCKS PNS) EFFECTS THAN QUINIDINE. SE IS ATROPINE LIKE EFFECTS. |
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Term
| WHAT CAN DISOPYRAMIDE DO TO CONTRACTILITY AND HEART FAILURE? |
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Definition
| DECREASE CONTRACTILITY AND CAN CAUSE HF. |
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Term
| WHAT IS DISOPYRAMIDE USED ONLY FOR? |
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Definition
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