Term
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Definition
Amantadine - Inhibits entry and viral uncoating by antagonism of M2 protein. Inhibits the Acidic environment from M2 because it increases pH and prevents M2 from working efficiently
Basic due to NH2
Hydrophilic in parkinsons
ONLY INHIBITS INFLUENZA TYPE A, does NOT work on Type B |
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Term
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Definition
| Zanamivir -Neuraminidase inhibitor, can only be given nasally and IV, NOT ACTIVE ORALLY |
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Term
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Definition
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Term
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Definition
Oseltamivir Metabolism
Prodrug that is extensively Metabolized in liver to active carboxylic acid
NEEDS Carboxylic acid on ring to be active |
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Term
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Definition
Valacyclovir
Everything from the C-C-O bond and over to the left is Valine component of valacyclovir (Val for valine)
Superior to acyclovir due to GI absorption and higher plasma concentration (longer half-life) |
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Term
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Definition
| Zidovudine - NRTI (Nucleoside Reverse transcriptase inhibitor) |
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Term
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Definition
| Efavirenz (Sustiva) - NNRTI |
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Term
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Definition
Protease inhibitors
Basic structure of this drug, not a represenation of ENTIRE structure
A. Native peptide, what the normal substrate looks like. This can be cleaved by the protease
B. Can NOT be cleaved by protease
C. Can NOT be cleaved by protease(Hydroxyethylene)
D. Can NOT be cleaved by protease (Hydroxethylamine) |
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Term
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Definition
| Saquinavir - Protease Inhibitor |
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Term
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Definition
| Raltegravir - Integrase inhibitor |
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