Term
| What drugs are used for Influenza A and B? |
|
Definition
|
|
Term
| What is the mechanism of Zanamivir and Oseltamivir? |
|
Definition
| Mimic sialic acid to inhibit virus neuraminidase, which is required for release of influenza virions. |
|
|
Term
| What are the side effects of Zanamivir and Oseltamivir? |
|
Definition
|
|
Term
| How is Zanamivir administered? |
|
Definition
| Dry powder that is inhaled |
|
|
Term
| How is Oseltamivir administered? |
|
Definition
|
|
Term
| What drugs are used against Hepatitis C? |
|
Definition
| Recombinant IFN-a and Pegylated IFN-a |
|
|
Term
| What are the mechanisms of IFN-a and pegylated IFN-a? |
|
Definition
| Enhance normal immune cell function, inhibit viral protein synthesis and mRNA processing |
|
|
Term
| What are the side effects of recombinant IFN-a and pegylated IFN-a? |
|
Definition
| Flu-like symptoms, depression, hypertension, retinal damage |
|
|
Term
| How is pegylated IFN-a different from recombinant IFN-a? |
|
Definition
| It contains polyethylene glycol. |
|
|
Term
| What are the common side effects of the HIV reverse transcriptase inhibitors? |
|
Definition
| Life-threatening hepatomegaly, lactic acidosis, anemia, neutropenia |
|
|
Term
| What are the nucleoside reverse transcriptase inhibitors? |
|
Definition
| "DAZLES T": Didanosine, Abacavir, Zidovudine, Lamivudine, Emtricitabine, Stavudine, Telbivudine |
|
|
Term
| What are the side effects of Didanosine? |
|
Definition
|
|
Term
| What are the side effects of Abacavir? |
|
Definition
| Hypersensitivity reaction |
|
|
Term
| What are the side effects of Zidovudine? |
|
Definition
|
|
Term
| What are the side effects of Lamivudine? |
|
Definition
|
|
Term
| What are the side effects of Emtricitabine? |
|
Definition
| Hepatomegaly and lactic acidosis |
|
|
Term
| What are the side effects of Stavudine? |
|
Definition
|
|
Term
| What are the side effects of Telbivudine? |
|
Definition
| Hepatomegaly, Lactic Acidosis |
|
|
Term
| What are the non-nucleoside reverse transcriptase inhibitors? |
|
Definition
| "NEED": Nevirapine, Efavirenz, Etravirine, Delavirdine |
|
|
Term
| What are the side effects of Nevirapine? |
|
Definition
| Hepatotoxicity, Stevens Johnson Syndrome |
|
|
Term
| What are the side effects of Efavirenz? |
|
Definition
| CNS toxicity (hallucinations), Contraindicated in pregnancy |
|
|
Term
| What are the side effects of Etravirine? |
|
Definition
|
|
Term
| What are the side effects of Delavirdine? |
|
Definition
| Metabolized by P450, Stevens Johnson Syndrome |
|
|
Term
| What are the protease inhibitors? |
|
Definition
| "-navirs" (IN DRAFTS): Indinavir, Nelfinavir, Darunavir, Ritonavir, Atazanavir, Fosamprenavir, Tipranavir, Saquinavir |
|
|
Term
| What are the side effects of all of the protease inhibitors? |
|
Definition
| Nausea and vomiting, P450 inhibition, altered fat distribution, increased incidence of DM |
|
|
Term
| Which non-nucleoside reverse transcriptase inhibitor is not phosphorylated? |
|
Definition
|
|
Term
| Which protease inhibitor has poor oral absorption? |
|
Definition
|
|
Term
| What are the side effects of Ritonavir? |
|
Definition
| Most potent P450 inhibitor, hepatotoxicity, Stevens-Johnson Syndrome |
|
|
Term
| What are the side effects of Indinavir? |
|
Definition
|
|
Term
| What are the side effects of Atazanivir? |
|
Definition
|
|
Term
| What are the side effects of Darunavir? |
|
Definition
|
|
Term
| Which protease inhibitor drugs contain sulfur and cause Stevens Johnson syndrome? |
|
Definition
| Fosamprenavir and Tipranavir |
|
|
Term
| Which drugs are fusion inhibitors? |
|
Definition
| Enfuvirtide and Maraviroc |
|
|
Term
| What is the mechanism of Enfuvirtide? |
|
Definition
| Inhibits binding of virus GP41 and GP120 to CD4 cells |
|
|
Term
| What is the mechanism of Maravaroc? |
|
Definition
| Binds to CCR5 on macrophages/CD4 T cells to prevent viral binding |
|
|
Term
| What are the side effects of Maraviroc? |
|
Definition
| Hepatotoxicity, Systemic allergic reactions |
|
|
Term
| Which drug is an integrase inhibitor? |
|
Definition
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