Term
|
Definition
Inhibit conversion of AA to PGs
Only give symptomatic relief, no disease mod
Lots of AE
Admin a PPI to prevent ulcer formation |
|
|
Term
|
Definition
Dec macrophages and IL-1, blocks phospholipase 1 to AA
Can be given in a shot
Can cause DM and osteoporosis
Best choice for pregnancy and bridging
Mostly used in end stage people |
|
|
Term
Hydroxychlorquine
MOA
PK
AE
DI |
|
Definition
Blocks T cells
Takes 3-6 months to onset, liver met, monitor ocular fxn
Macular damage and retinopathies
Best for mild RA |
|
|
Term
|
Definition
Chelator of divalent cations, may effect PMNs
3 months, liver met
Rarely used due to tox: GI, blood, proteinuria, heavy metal dx |
|
|
Term
|
Definition
Macrophage and PMN fxn
4-6 m, mostly urine exc. IM > PO
Proteinuria, dermatitis, can slow dx, response generally good |
|
|
Term
|
Definition
Inhibits DHFR, slows progression of RA, *Gold standard
4-6 weeks, renal excretion
Admin of folic acid can offset SE: stomatitis, myelosupression, hepatotox, plum tox, monitor LFTs, CBC, PFT
Interacts with sulfonamides, NSAIDs ad omeprazole |
|
|
Term
|
Definition
Conjugate of sulfapridine and mesalamine, mild dx only
1-6 m, anorexia, dyspepsia, HA
Need folate supp |
|
|
Term
|
Definition
Prodrug met to 6MC, blocks DNA and RNA synth, rarely used
Hep met xanthine oxidase,
dose related myelosuppression, somtatitis, skin rash
Dose reduce when using allopurinol |
|
|
Term
|
Definition
Blocks T cell activation, alt to methotrexate
Met CYP3A
Renal insufficiency |
|
|
Term
|
Definition
Prodrug, blocks clonal expansion of act lymphocytes
As effective as methotrexate
Highly protein bound, renal, fecal slim
Hepatotx and teratogenic |
|
|
Term
|
Definition
Binds TNF-a, used in combo with MTX, fixes C and lyses cells
IV every 8 weeks, predisposition to infection |
|
|
Term
|
Definition
Human protein binds TNF, does not fix C or lyse cells
SQ weekly, predisposition to infection |
|
|
Term
|
Definition
Recombinant for IL-1, SQ daily
Infection |
|
|
Term
|
Definition
|
|
Term
|
Definition
Inhibits T cell activation, can't be taken with TNF blockers
Infection and lung cancer?
only used after failure of another drug |
|
|
Term
|
Definition
| Binds CD20 on B cells, infection |
|
|
Term
|
Definition
|
|
Term
|
Definition
Acute gout, anti inflame spec for gout, blocks phag of irate crystals by neutrophils
Hepatic elim, narrow TR, agranulocytosis, TTP
Avoid: hepatic and renal impair, avoid in elderly |
|
|
Term
|
Definition
XO blocker, blocks UA formation.
Renal dose adj. Effect in 1-3 weeks
Can make acute attack worse
Skin rash, HSN rxn, alopecia, leukopenia |
|
|
Term
|
Definition
XO blocker, no renal dose adj
Cardiac SE, don't start acutely
For pts who can't take allopurinol |
|
|
Term
|
Definition
| Pegylated urate oxidase, for ppl who fail febuxostat |
|
|
Term
|
Definition
Uricosuric agent, blocks tubular reabsorption of irate
Only use if CrCL > 30
May exacerbate acute attack |
|
|
Term
|
Definition
Similar to Probenacid
Not well tolerated |
|
|
