Term
|
Definition
Zidovudine, Zalcitabine, Diadanosine, Stavudine, Abacavir, tenofovir, Lamivudien, emcitabine |
|
|
Term
|
Definition
substrate for RT, lack 3'OH group can't elongate RNA |
|
|
Term
NRTI's- what cells does it work in |
|
Definition
|
|
Term
|
Definition
|
|
Term
What is given to mother to prevent spread of HIV during child birth |
|
Definition
|
|
Term
|
Definition
Lactic Acidosis (mtDNA interference) hepatic steatosis N/V/D, fatigue, insomnia drugs with a d cause reversible, does dependent peripheral neuropath |
|
|
Term
|
Definition
|
|
Term
|
Definition
Bone marrow suppression malaise, myopathies, N/V, HA |
|
|
Term
Zidovudine- Contraindications |
|
Definition
Don't give to people with Ganciclovir, used to tx CMV |
|
|
Term
|
Definition
|
|
Term
|
Definition
peripheral neuropathy, pancreatitis |
|
|
Term
|
Definition
|
|
Term
|
Definition
Pancreatitis- deadly Peripheral neuritis is common |
|
|
Term
|
Definition
Do not take with meals, acid will destroy the drug |
|
|
Term
|
Definition
|
|
Term
|
Definition
lipodystrophy- prevrent with pravastatin and atrovastatin peripheral nueropathy |
|
|
Term
|
Definition
|
|
Term
|
Definition
hypersensitivity rxn- deadly |
|
|
Term
|
Definition
|
|
Term
Lamivudine, emtricitabine- AE |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Nevirapine, delavirdine, enfavirenz, etravirine, rilpirivine |
|
|
Term
|
Definition
non competitive antagonist of RT |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
1 codon change- very common |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
Nevirapine- effect on CYP450 |
|
Definition
|
|
Term
Delvaridine- CYP450 inducer or inhibitor |
|
Definition
|
|
Term
|
Definition
Abnormal CNS effects- vivid dreams, insomnia, dizziness |
|
|
Term
|
Definition
don't take with fatty meals |
|
|
Term
Efavirenz- Contraindications |
|
Definition
|
|
Term
|
Definition
last line, NNRTI is have developed resistance to all the others |
|
|
Term
|
Definition
|
|
Term
|
Definition
Indinavir, atazanavir, tipranavir, fosamprenavir, lopinavir, nelfinavir, ritonavir, saquinavir |
|
|
Term
|
Definition
binds to active site of protease --> cant cleave the polyprotein |
|
|
Term
|
Definition
|
|
Term
|
Definition
hyperglycemia, dyslipidemia, lipodystrophy, osteoperosis, GI disturbances, redistribution of fat from face and extremities to waist |
|
|
Term
|
Definition
|
|
Term
|
Definition
redistribution of fat from face and extremities to waist, HIV lymphodystrophy syndrome. Tx atrovastatin, provastatin |
|
|
Term
|
Definition
inhibitors or CYP3A4 --> lots of drug interactions |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
PI- order of CYP3A4 interactions |
|
Definition
Ritonavir- greatest squinavir- least |
|
|
Term
|
Definition
Kidney stones hyperbillirubinemia alopecia |
|
|
Term
|
Definition
prolonged PR- messes up atria hyperbiirubinemia |
|
|
Term
Tipranavir- Intracranial hemorrhage |
|
Definition
|
|
Term
|
Definition
largest inhibitor of CYP3A4 enzyme --> inhibits metabolism of other HIV drugs, so saves $ |
|
|
Term
|
Definition
|
|
Term
|
Definition
binds to gp41 env protein and prevents fusion of HIV to cell |
|
|
Term
|
Definition
1 codon change, low barrier |
|
|
Term
Enfuviritide- HIV1,2, both |
|
Definition
|
|
Term
|
Definition
last ditch when all other drugs have failed |
|
|
Term
|
Definition
Injection site rxns, N/D, fatigue, Neutropenia |
|
|
Term
|
Definition
|
|
Term
Enfuviritide- protein binding |
|
Definition
|
|
Term
|
Definition
Proteloytic degridation, not hepatic metabolism |
|
|
Term
|
Definition
Maraviroc Raltegavir Etravirine |
|
|
Term
|
Definition
binds to CCR5, CCR5 antagonists, HIV can't bind |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
really an NNRTI that is used when other drugs have failed |
|
|