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Anti-psycotics
Typical vs. Atypical
11
Medical
Professional
02/14/2013

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Cards

Term
chlorpromazine
Definition
prototypical TYPICAL ANTI-PSYCOTIC
D1 receptor agonist (mostly)

1. Least Potent; most sedative
2. can cause HYPOTENSION AND WEIGHT GAIN, dry mouth, galactorrhea,

Extrapyrimidal effects come from D2 receptor blockade
Term
Fleuphenazine
Definition
Typical anti-psycotic

Associated with neuroleptic malignant syndrome
Term
Thiothixene
Definition
typical anti-psycotic

typical side effects
Term
Haloperidol
Definition
typical anti-psycotic

HIGHEST EXTRAPYRAMIDAL EFFECTS

May cause MALIGNANT NEUROLEPTIC SYNDROME: triad rigidity, fever, and cognitive changes due to hypoactivation D2... Treat with benzo or dantrolene
Term
Clozapine
Definition
Prototypical ATYPICAL ANTI-PSYCOTIC

not used because of Agranulocytosis; weight gain; hypotension.. good for suicide patients
Term
Aripiprazole
Definition
Atypical Anti-psycotic

Only PARTIAL D2 agonist. Associated with least amount of extrapyrimidal and sedative effects.
Term
Ziprasidone
Definition
Atypical Antipsycotic

Least associated with weightgain. MOST ASSOCIATED WITH PROLONGED QT.
Term
Risperidone
Definition
Atypical anti-psycotic associated with EXTRAPYRIMIDAL EFFECTS
Term
Olanzipine
Definition
atypical antipsycotic associated with EXTRAPYRIMIDAL EFFECTS AND WEIGHT GAIN
Term
Quetiapine
Definition
Atypical anti-psycotic
Term
Neuroleptic malignant syndrome
Definition
rigidity, fever, cognitive changes
treat dantrolene
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