Term
| What are the differences between Conventional and Atypical Antipsychotic drugs? |
|
Definition
Conventional treats only the positive sympotoms and blocks Dopamine only.
Atypicals treat positive and negative symptoms; Blocks serotonin more than dopamine. |
|
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Term
| Antipsychotics mechanism of action |
|
Definition
blocks excess dopamine and serotonin
-Treats psychosis
--acute psychosis (at the moment)
--Schizophrenia (chronic)
--Mania |
|
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Term
| What symptoms are shown in Schizophrenia? Positive or Negative? |
|
Definition
|
|
Term
| What are positive symptoms? |
|
Definition
(characterized by the PRESENCE of unusual feelings)
--hallucinations, delusions, etc.
[too much DOPAMINE] |
|
|
Term
| What are negative symptoms? |
|
Definition
(characterized by the ABSENCE of experience)
--not very emotionally expressive.
[DOPAMINE DEPLETION--too much SEROTONIN] |
|
|
Term
|
Definition
[Extrapyramidal Symptoms]
caused by decreased dopamine in mesolmphic system. |
|
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Term
|
Definition
Akathisia
Tardive dykinesia
acute dystonia
Parkisonism |
|
|
Term
|
Definition
acute dystonia--muscle tone problem
(life threatening--laryngospams) |
|
|
Term
|
Definition
| Parkinsonism--move very slowly and shuffle when they walk.(bradykinesia, tremors, rigidity) |
|
|
Term
|
Definition
| Akathisia--sudden constant uncontrollable movement |
|
|
Term
| What is Tardive dyskinesia? |
|
Definition
Tardive dykinesia- slow involuntary uncontrallable movements. (irreversible, last side effect)
Neuroleptic malignant syndrome--ANS derangement (all over the place). One minute BP up, next minute BP down, and temp changes.
--idiosyncratic, not predictable.
--high mortality, but rare
--LEAD PIPE RIGIDITY, fever, confusion |
|
|
Term
| Side Effects of Antipsychotics? |
|
Definition
EPS, Sedation, Anticholinergic Symptoms, Orthostatic Hypotension,
Weight gain (Zyprexa) |
|
|
Term
| Why is Weight gain a symptom? |
|
Definition
| Serotonin usually suppresses hunger, if you block serotonin, you get hungry all the time. |
|
|
Term
| Which receptor blocker causes the more severe side effects related to AntiPsychotics? |
|
Definition
| blockage of th ALPHA 1 receptor can cause vasodilation. |
|
|
Term
| Clozaril and agranulocytosis |
|
Definition
check patients base WBC and neutrophil count before and during therapy.
[drug-induced agranulocytosis] |
|
|
Term
|
Definition
| acute condition involving a severe and dangerous leukopenia (lowered white blood cell count), most commonly of neutrophils, causing a neutropenia in the circulating blood |
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