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Anti-psychotics
Pharmacology
18
Medical
Professional
01/21/2012

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Cards

Term
the phenothiazines
Definition
chloropromazine
thioridazine
fluphenazine
Term
butyrophenones
Definition
haloperidol
Term
what are the most potent anti-psychotic
Definition
butyrophenones (haloperidol)
piperazine (fluphenazine)
Term
anti-psychotics w/greater extra pyramidal symptoms
Definition
higher potency ones
Term
which anti-psychs have greater alpha blocking activity
Definition
lower potency ones
Term
sedation characteristics
Definition
lower potency has greater effects
Term
anti-psych that can stop hiccups
Definition
chlorpromazine
Term
mech of action for anti-psychs
Definition
blocking of dopamine in mesolimbic/cortical system
Term
where do the extra pyramidal side effects come from?
Definition
nigrostriatal system
Term
which dopa receptor is blocked
Definition
D2 subtype
Term
which have active metabolites
Definition
aliphatic and piperidine phenothiazines
Term
early motor fluctuations?
Definition
dystonia- 1-5 days
akathisia- 5-60 days
parkinson- 5-30 days

treat w/anticholinergics
Term
late motor fluctuations?
Definition
tardive dyskinesia
peri oral tremor
Term
endocrine problems of anti-psych
Definition
hyperprolactinemia
decreased GnRH release
Term
what is best choic in epileptic patient?
Definition
piperazine
phenothiazines
fluphenazines
Term
treatment for neuroleptic malignant syndrome
Definition
dantrolene
Term
Adverse autonomic effects of anti-psychs
Definition
lower potency especially

muscarinic blockade (dry, constipated...)
Term
what are high potency antipsychs contra'd in
Definition
pts w/pre-existing pyramidal disorders
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