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Anti-neoplastics 2 and 3
Pharmacology
36
Medical
Professional
10/01/2011

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Term
This vinca alkaloid is not available for oral use
Definition
vincristine
Term
This vinca alkaloid has poor penetration across the blood brain barrier and into the CSF
Definition
vincristine
Term
How is resistance developed in vinca alkaloids?
Definition
overexpression of the P170 glycoprotein

mutation in alpha and beta tubulin proteins
Term
Caution should be given in patients taking vinorebiline
Definition
abnormal liver function
chemo/radiation therapy
breast feeding mothers
Term
Side effects if vinca alkaloids
Definition
Neutropenia (most common)
nausea
GI toxic
Neurotoxicity
Myelosuppression
Term
This agents acts in late S and G2 phase of cell cycle by inhibiting TOPO II
Definition
Etoposide
Term
mech of resistance for etoposide
Definition
expression of P170 glycoprotein
Term
what is etoposide cross-resistant to
Definition
vinca alkaloids, anthracyclines, taxanes
Term
how is etoposide metabolized?
Definition
the liver via glucuronidation acid metabolites
Term
Etoposide toxicity
Definition
Alopecia (most important)
Nausea
Anorexia
Myelosuppression
Term
what is the mech of resistance for Doxorubicin?
Definition
increased expression of gene with P170 levels
increased expression of sulfhydryl proteins
Term
Side effects of Doxirubicin
Definition
cardiotoxicity
Term
What is the mech of resistance for Bleomycin
Definition
activation of bleomycin hydrolase
increased expression of DNA repair repair enzymes
Term
Doxorubicin mech of action
Definition
free radical intercalating w/DNA preventing replication
Term
how is bleomycin eliminated?
Definition
by the kidney
Term
Side effects of bleomycin
Definition
pulmonary toxicity
Term
what is the purpose of L-asparaginase?
Definition
hydrolyzes L-asparagine( starves tumor cells)
Term
what is the indication for L-asparginase
Definition
acute lymphocytic leukemia
Term
side effect of L-asparaginase
Definition
Anaphylaxis
fever, chills
neuro
PANCREATITIS
Term
Alpha interferon mech of action
Definition
develops Ab's to IFN-a
Term
How is alpha interferon absorbed?
Definition
Systemic circulation after IM or SC injection
Term
Major route of metabolism for alpha interferon
Definition
kidney
Term
what is alpha interferon contraindicated in
Definition
autoimmune disease, hepatitis
Term
Interleukin 2 function
Definition
stimulation of T cell immunity
Term
Cisplatin mechanism of action
Definition
produces cross-links on DNA
binding to nuclear and cytoplasmic proteins.
Term
Does Cisplatin or Carboplatin cross the BBB?
Definition
Carboplatin
Term
Toxicity of Cisplatin
Definition
nephrotoxicity
nausea
myelosuppression
neurotoxicity
OTOXICITY!!!
Term
Which drug is cleared by the kidney the fastest? Carbo or cis?
Definition
Carbo- 70% excreted w/i 24 hours
Term
Which is less toxic, Carboplatin or Cis
Definition
Carboplatin
Term
mech of action for hydroxyurea
Definition
activity in S phase
inhibits ribonucleotide reductase- decreasing DNA synthesis and repair
Term
Toxicity of Hydroxyurea
Definition
GI upset
myelosuppression
Term
Vinca alkaloids cell cycle specificity
Definition
Mitosis
Term
DOC soft tissue sarcoma
Definition
Doxorubicin
Term
enzyme used to treat Acute lymphocytic leukemia
Definition
L-asparaginase
Term
These agents introduce cross-links at the A-G position
Definition
Cisplatin and Carboplastin
Term
Mech of action for Hydroxyurea
Definition
Inhibits ribonucleotide reductase
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