Term
This vinca alkaloid is not available for oral use |
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Definition
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Term
This vinca alkaloid has poor penetration across the blood brain barrier and into the CSF |
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Definition
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Term
How is resistance developed in vinca alkaloids? |
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Definition
overexpression of the P170 glycoprotein
mutation in alpha and beta tubulin proteins |
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Term
Caution should be given in patients taking vinorebiline |
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Definition
abnormal liver function chemo/radiation therapy breast feeding mothers |
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Term
Side effects if vinca alkaloids |
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Definition
Neutropenia (most common) nausea GI toxic Neurotoxicity Myelosuppression |
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Term
This agents acts in late S and G2 phase of cell cycle by inhibiting TOPO II |
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Definition
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Term
mech of resistance for etoposide |
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Definition
expression of P170 glycoprotein |
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Term
what is etoposide cross-resistant to |
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Definition
vinca alkaloids, anthracyclines, taxanes |
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Term
how is etoposide metabolized? |
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Definition
the liver via glucuronidation acid metabolites |
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Term
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Definition
Alopecia (most important) Nausea Anorexia Myelosuppression |
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Term
what is the mech of resistance for Doxorubicin? |
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Definition
increased expression of gene with P170 levels increased expression of sulfhydryl proteins |
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Term
Side effects of Doxirubicin |
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Definition
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Term
What is the mech of resistance for Bleomycin |
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Definition
activation of bleomycin hydrolase increased expression of DNA repair repair enzymes |
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Term
Doxorubicin mech of action |
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Definition
free radical intercalating w/DNA preventing replication |
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Term
how is bleomycin eliminated? |
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Definition
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Term
Side effects of bleomycin |
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Definition
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Term
what is the purpose of L-asparaginase? |
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Definition
hydrolyzes L-asparagine( starves tumor cells) |
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Term
what is the indication for L-asparginase |
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Definition
acute lymphocytic leukemia |
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Term
side effect of L-asparaginase |
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Definition
Anaphylaxis fever, chills neuro PANCREATITIS |
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Term
Alpha interferon mech of action |
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Definition
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Term
How is alpha interferon absorbed? |
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Definition
Systemic circulation after IM or SC injection |
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Term
Major route of metabolism for alpha interferon |
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Definition
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Term
what is alpha interferon contraindicated in |
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Definition
autoimmune disease, hepatitis |
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Term
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Definition
stimulation of T cell immunity |
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Term
Cisplatin mechanism of action |
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Definition
produces cross-links on DNA binding to nuclear and cytoplasmic proteins. |
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Term
Does Cisplatin or Carboplatin cross the BBB? |
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Definition
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Term
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Definition
nephrotoxicity nausea myelosuppression neurotoxicity OTOXICITY!!! |
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Term
Which drug is cleared by the kidney the fastest? Carbo or cis? |
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Definition
Carbo- 70% excreted w/i 24 hours |
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Term
Which is less toxic, Carboplatin or Cis |
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Definition
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Term
mech of action for hydroxyurea |
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Definition
activity in S phase inhibits ribonucleotide reductase- decreasing DNA synthesis and repair |
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Term
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Definition
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Term
Vinca alkaloids cell cycle specificity |
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Definition
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Term
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Definition
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Term
enzyme used to treat Acute lymphocytic leukemia |
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Definition
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Term
These agents introduce cross-links at the A-G position |
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Definition
Cisplatin and Carboplastin |
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Term
Mech of action for Hydroxyurea |
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Definition
Inhibits ribonucleotide reductase |
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