Alprostadil

• PGE1 (prostaglandin)
• temporarily maintains Patent ductus arteriosis

Indomethicin

• Cyclooxygenase inhibitor, inhibits prostaglandin synthesis
• Closes Patent ductus arteriosis

• prostaglandin analog
• oral tx for gastric ulcers
• side effects: abdominal discomfort, diarrhea

Dinoprostone and carboprosttromethamine

• PGE2, PGF2a
• contract uterus

• intramuscularly, it can be used instead of oxytocin to reduce postpartum hemorrhage

• analgesic, antipyretic, anti-inflammatory, anti-platelet, Classic NSAID
• completely absorbed from stomach and intestine in unionized form
• Irreversibly inhibits prostaglandin biosynthesis by acetylating COX

• weak base
• analgesic, antipyretic, NOT anti-inflammatory or anti platelet
• Side effect: Severe hepatotoxicity, N-acetylcysteine prevents this

• COX-2 inhibitor, sulfonamide
• significant first pass metabolism
• COX2 inhibitors reduce production of prostacyclin, an antithrombotic

• Enters cell membrane, goes to GRE pro, increase steroid responsive tgt genes, decrease cytokines, NK
• Side effects: adrenal atrophy, hypertension, GI bleeding, immunosuppression, fetal growth retardation, cataracts and glaucoma

Zileuton

• inhibits 5-lipoxygenase, (leukotriene modifier)
• inhibits CYP3A4--influences metab of terfenadine, warfarine and theophylline
• Tx for mild to mod athsma, alternative to inhaled corticosteroids

Zarfirlukast and Montelukast

• Leukotriene receptor antagonist
• Inhibits CYP3A4/CYP2C9: increase warfarin 1/2 life
• Tx for mild to moderate athsma, alternative to inhaled corticosteroids

Hydroxychloroquinone

• Anti malarial agent, Disease modifying Antirheumatic drug (DMARD)
• Tx for rheumatoid arthritis

• Chelating agent, DMARD
• Tx for RA

• Immunosuppressive, DMARD
• Tx for RA
• Prevent proliferation of B and T cells
• Inhibits TNF-a function
• Co-administer with methotrexate to reduce development of Ab to drugs; long term tx

• Inhibits TNF-a function, cytokine blocker
• Tx for RA

• Inhibits IL-1 function
• Tx for RA

• Inhibits T cell activation by mimicking CD28 and preventing CD28 from binding CD80 via costimulatory pathway
• approved tx for RA patients who don't respond to anti TNF-a tx
• Side effects: can't use DMARD with abatacept, frequent infections

• Inhibits B cell function
• tx for RA when anti TNFa fails, and non hodgkins lymphoma
• Side effect: Fatal infusion reaction within 24 hours of infusion

• aka Triaminic
• short duration (3-6 hr), cause sedation, anti-nausea, anti motion sickness
• 1st gen H1 Receptor antagonist

• Aka Benadryl
• short duration (3-6 hr), causes sedation
• 1st generation HI Receptor antagonist
• anti nausea, anti motion sick
• anticholinergic, anti a-adrenergic, antiserotonergic effects

• 2nd gen H1 Receptor antagonist
• Don't penetrage CNS, therefore no sedation
• not useful for antinausea, not anticholinergic, a-andronergic or serotonergic
• long duration (12-24 hr)

• Aka Zyrtec
• 2nd gen H1 Receptor antagonist
• no anticholinergic, anti a adrenergic or anti serotonergic, no sedation, no antinausea
• Long duration (12-24 hr)
• Doesn't penetrate CNS

• Serotonin agonist
• don't administer with SSRI--restlessness, hallucinations, loss of coord, tachycardia, rapid bp, increased body temp

• potent inhibitor of P450 metabolism
• H2 receptor antagonists
• reduces NSAID induced dyspepsia, esophageal reflux

• Seratonin Antagonist
• Ser5ht3, antagonish for nausea and vomiting