Term
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Definition
CCB's Hydralazine Minoxidil -Nitroprusside |
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Term
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Definition
preventing Ca ions from entering the pl.mem. of sm muscle->vasodilation -> decr PVR Art>veins |
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Term
| Which 2 CCB's reduce HR and CO as well as vasodilation? |
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Definition
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Term
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Definition
glucose, lipids, uric acid, OR ELECTROLYTES |
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Term
| CCB's are esp useful in what population? |
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Definition
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Term
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Definition
fatigue, HA, dizziness, flushing, peripheral edema Verapamil-CONSTIPATION |
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Term
Caution when using CCB's in pts w/ |
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Definition
SA node brady AV node pt/complete block decr contractility |
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Term
| CCB's are used prophylactically to tx |
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Definition
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Term
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Definition
| BB d/t similar effects and can alter HR |
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Term
| Vasodilators do not inhibit |
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Definition
symp nervous system = NO PROBS W/ ORTHOSTATIC HYPOTN and IMPOTENCE |
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Term
Vasodilators are very good in treating HTN when combined w/ |
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Definition
BB and diuretic ***Alone, physiological compensation cause inadequate tx!! |
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Term
| MOA of Diazoxide and Minoxidil |
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Definition
activate K causing HYPERPOLARIZATION -> art. relaxation |
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Term
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Definition
increase in cGMP-> sm mm. relaxation d/t N.O. generation |
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Term
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Definition
| causes release of N.O. and activates K channels |
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Term
| Metabolism of Hydralazine |
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Definition
N-acetylation (some fast some slow, MONITOR) |
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Term
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Definition
INCR CO d/t: incr symp stimulation, incr. renin Na and H2O retention (use diuretic) |
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Term
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Definition
HTN ambulatory pts whose BP not controlled by duiretics + other drugs that disrups SNS signals (diuretic + BB) oral and IV |
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Term
| Minoxidil is </> Hydralazine at reducing BP |
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Definition
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Term
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Definition
EXCESSIVE HAIR GROWTH HA nasal cong tachy palpitations |
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Term
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Definition
Sereve HTN (life-threatening) HTN resistant to other forms tx HTN w/ chronic renal dz |
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Term
| Diazoxide is similar to what drugs |
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Definition
| thiazides (w/o diuretic action) |
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Term
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Definition
Activates K channels -> art relaxation -> incr. CO also causes Na and H2O retention (diuretic) |
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Term
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Definition
Incr workload may ppt ischemia and Na and H2O retention Hyperglycemia (No DM) Stop labor when used in eclampsia |
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Term
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Definition
stimulates cGMP production -> relaxes VEINS and ARTS -> decr PVR and venous return Does not inhibit symp reflexes -> incr HR Incr renin decr preload and afterload |
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Term
| uses of sodium nitroprusside |
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Definition
HTN crisis Tx severe HTN w/ acute MI and LV failure |
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Term
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Definition
toxicity of cyanide poisoning (delerium, psychosis) N/V HA Hypothyroidism |
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