Term
| Alpha Adrenergic Receptor Antagonist Drugs |
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Definition
1. Prazosin 2. Terazosin 3. Doxazosin |
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Term
MOA Alpha Adren. Antagonists |
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Definition
Inhibit Symp. stimulation on art. contraction (mild effect on veins) |
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Term
Why are they "selective" A-1 blockers? |
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Definition
| do not potentiate release of NE from symp n. |
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Term
selective A-1 antagonists prevent vasoconstriction where? |
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Definition
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Term
| venous dilation can lead to? |
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Definition
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Term
| in severe HTN A-1 blockers should be combined w/ what 2 drugs? |
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Definition
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Term
Do A-1 blockers alter uric acid levels? |
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Definition
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Term
| Do A-1 blockers affect glucose levels? |
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Definition
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Term
| Do A-1 blockers cause an ↑ or ↓ in lipids? |
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Definition
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Term
Is Prozasin highly protein bound? |
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Definition
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Term
| Most imp. pharm effect of prozasin |
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Definition
-ability to antagonize sm. mm. contraction caused by: 1) symp activity 2) action of adrenomimetics |
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Term
How does Prazosin compare to vasodilators? |
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Definition
| less prominent incr. in HR, Contractile force, and Renin activity |
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Term
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Definition
Postural hypotn = Dizziness/light-headed ***esp initial tx and when dose incr. |
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Term
| Centrally acting sympatholytics |
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Definition
1. clonidine 2. alpha methyldopa 3. guanabenz 4. guanfacine |
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Term
| How do centrally acting sympatholytics work? |
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Definition
| reduce symp output from vasopressor center in brainstem -> CV system |
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Term
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Definition
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Term
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Definition
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Term
| Does Clonidine cross the BBB? |
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Definition
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Term
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Definition
sedation, dry mouth, bradycard, impotence *** decr w/ TD patch but causes contact derm |
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Term
| who should not be given clonidine? |
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Definition
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Term
| Does clonidine effect lipids? |
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Definition
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Term
Why is Clonidine useful for pts w/ complicated renal dz? |
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Definition
does not reduce renal blood flow or GFR **does reduce renin activity!! (decr symp on juxt. cells) |
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Term
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Definition
mild/mod HTN tourettes hot flashes etoh withdrawal smoking cessation |
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Term
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Definition
| alphamethyldopa -> alpamethylNE = decr symp outflow |
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Term
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Definition
mild-mod HTN Prego women!! |
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Term
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Definition
tx of HTN in renal dz (NOT END STAGE) does not reduce renal blood flow or GFR |
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Term
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Definition
Sedation (CNS) drymouth, nasal cong. impotence orthostatic HTN |
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Term
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Definition
Autoimmune RXN -> COOMBS Hyperprolactinemia |
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Term
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Definition
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Term
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Definition
severe HTN **most potent antiHTN = LOTS OF SE |
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Term
| Guanethidine contraindications |
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Definition
not in pheochromocytoma NO MOAI's can worsen CHF |
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Term
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Definition
1. Guanethidine 2. Reserpine 3. Ganglionic blockers |
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Term
| uses of ganglionic blockers |
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Definition
ONLY malignant HTN =non-selective blocking |
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Term
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Definition
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Term
| Reserpine should be used w/? |
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Definition
| diuretic -> expand vasc volume |
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Term
| Reserpine contraindicated in |
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Definition
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Term
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Definition
CNS- sedation, depression, nightmares, suicide nasal cong. postural hypotn. diarrhea ect |
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Term
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Definition
1. Enalapril 2. Lisinopril 3. Captopril 4. Fosinopril |
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Term
Do kidneys provide LT or ST control of BP?? how? |
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Definition
| LT by altering blood volume -> stimulate renin release = Na and H2O retn. |
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Term
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Definition
inhibit conversion of AT I -> AT II inhibit bradykinin degredation |
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Term
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Definition
Vasodilation d/t decr AT II Vasodilation 2nd incr bradykinin Decr. Na and H20 retn 2nd decr aldosterone |
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Term
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Definition
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Term
ACE I similar effect on wt. and AA when combined w/ |
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Definition
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Term
ACE-I offer protection in |
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Definition
DM: slow nephropathy and decr albuminuria CHF: stop vent. remodeling by decr AT II MI/stroke |
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Term
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Definition
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Term
| Which ACE-I can be used 1/day |
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Definition
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Term
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Definition
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Term
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Definition
Dry cough rash metallic taste angioedema (rare but fatal) **MONITOR 1st Dose! |
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Term
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Definition
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Term
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Definition
block the AT in vasculature and adrenal cortex -> vasodilate and decr aldosterone secretion |
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Term
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Definition
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Term
| Do ARB's effect bradykinin degredation? |
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Definition
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Term
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Definition
PREGO Renal impairment Renal Stenosis SEVERE HF |
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Term
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Definition
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