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Anti-folate
chemo 4
14
Pharmacology
Graduate
11/12/2012

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Cards

Term
Sulfamethoxazole
Definition
Folate antagonist-PABA Analogs-Dihydropteroate Synthetase Inhibitors. inhibit folate synthetis, Newer
Term
Sulfasalazine
Definition
Folate antagonist-PABA Analogs-Dihydropteroate Synthetase Inhibitors. GI, does not get absorbed systemically. Chronic bowel disease
Term
Silver sulfadiazine (Silvadene)
Definition
Folate antagonist-PABA Analogs-Dihydropteroate Synthetase Inhibitors. Topical. for burns
Term
Sulfisoxazole
Definition
Folate antagonist-PABA Analogs-Dihydropteroate Synthetase Inhibitors. Newer
Term
Sulfacetamide
Definition
Folate antagonist-PABA Analogs-Dihydropteroate Synthetase Inhibitors. Opthalamic
Term
Trimethoprim
Definition
Folate antagonist-DHF reductase inhibitor, more potent than sulfa drugs, broader spectrum, less resistance
Term
Pyrimethamine
Definition
Folate antagonist-DHF reductase inhibitor, more potent than sulfa drugs
Term
Trimethoprim + sulfamethoxazole
Definition
Folate antagonist-Cotrimoxazole (combination). synergism- inhibition of 2 sequential steps in synthesis of tetrahydrofolic acid synthesis, selective inhibition of bacterial dihydrofolic acid reductace.
Term
sulfa drugs
Definition
bacteriostatic, broad spectrum, active against gm + & -. UTI, chamydia, pneumocystis, nocardia
Term
Crystalluria, nephrotoxicity; hypersensitivity, rashes, photosensitivity, angioedema; stevens-johnson syndrome; hemolytic anemia, granulocytopenia, thrombocytopenia. CI preggo
Definition
AE sulfa drugs
Term
folate deficiency, megaloblastic anemia, leukopenia, granylocytopenia,
Definition
AE trimethoprim
Term
Sulfadiazine + Pyrimethamine
Definition
Folate antagonist-(combination. DOC toxoplasmosis, chloroquine-resistant malaria.
Term
skin, GI, megaloblastic anemia, G6PD deficiency, HIV, drug interactions
Definition
AE combination drugs
Term
Methenamine
Definition
Formaldehyde- Sulfonamides CI with the drug- condense
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