Term
| MOA of class 1a antidysrhythmics |
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Definition
blocks fast Na channels to lesser extent blocks K channels too |
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Term
| what are the class 1a drugs |
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Definition
quinidine disopyramide procainamide |
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Term
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Definition
moderate anticholinergic** blocks Na channels |
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Term
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Definition
long term suppression of SVT, Afib, A flutter supraventricular, and ventricular (lesser extent) |
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Term
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Definition
oral hepatic met. Q. sulfate Q. gluconate Q. polygalacturonate |
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Term
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Definition
GI CHICHONISM: tinnitis,vertigo, N Cardiotoxic: Sinus Arrest, AV block Vtach, Asystole Thrombocytopenia Hypotn hypersensitivity |
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Term
| EKG changes for cardiotoxicity of quinidine |
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Definition
| prolonged QRS, PRI, and torsades |
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Term
| quinidine incr, mortality of pts w/ what |
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Definition
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Term
| IV admin of quinidine assoc w/ |
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Definition
| hypotn (alpha-adrenergic ant) |
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Term
| how does quinidine affect dig levels |
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Definition
doubles! displaces from albumin and decr met |
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Term
| what drugs do quinidine intesify |
|
Definition
anticholinergics: dt anticholinergic responsibilities Warfarin |
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Term
| what drugs decr quinidine levels |
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Definition
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Term
|
Definition
block Na channels weak anticholinergic |
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Term
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Definition
LT suppression of atrial and ventr. dysrythmias ***limited by AE's |
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Term
|
Definition
oral, short t 1/2 hepatic met renal excretion active met (NAPA class III) |
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Term
| does procainamide have an active met? |
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Definition
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Term
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Definition
NAPA accumulates and toxit to kidney SLE-like synd. blood dyscrasias: Neutropenia, agranulocytosis, thrombocytopenia Cardiotoxic: prolong QT |
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Term
| EKG changes of procainamide |
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Definition
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Term
|
Definition
allergy to procaine = hypersensitivity! |
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Term
|
Definition
blocks Na channels most potent anticholinergic!! |
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Term
|
Definition
vent dysrythmias atrial tachy ↓ contractility pts who do not respond to quin and proc. |
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Term
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Definition
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Term
|
Definition
anticholinergic (dry mouth const ect) hypotn (neg inotropic) |
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Term
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Definition
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Term
|
Definition
| block fast Na -> specifically damaged cells |
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Term
tx uses of Class 1B drugs |
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Definition
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Term
| EKG changes of class 1B drugs |
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Definition
no signif changes reduct. in QT no widening of QRS |
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Term
|
Definition
lidocaine mexiletine tocainide |
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Term
|
Definition
| block fast Na channels-> spec damaged |
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Term
|
Definition
vent. dysrythmias-ST tx dig induced dysrythmia |
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Term
|
Definition
vent dysrythmia w/ MI and cardio surg |
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Term
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Definition
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Term
|
Definition
CNS: drowsiness confusion toxic: convulsions, resp arrest ASK: hypersensitivity to local anesth. |
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Term
what drugs incr levels of lidocaine |
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Definition
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Term
| what does lidocaine NOT tx |
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Definition
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Term
|
Definition
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Term
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Definition
vent dysrythmias VPB's sustained vtach |
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Term
| what drug is used to tx dig induced dysrythmia |
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Definition
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Term
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Definition
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Term
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Definition
Narrow TI*** toxicity: hand tremor, dizziness, blurred vision GI |
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Term
| EKG changes of mexiletine toxicity |
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Definition
QRS widening -> only in toxicity otherwise NO EKG changes normally |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
GI Neuro blood dyscrasias: agranulocytosis |
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Term
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Definition
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Term
|
Definition
block fast Na channels slow conduction inhibit abnormal automaticity |
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Term
| EKG changes of class 1C drugs |
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Definition
incr ERP prolong PRI widen QRS |
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Term
| class 1 C drugs used to tx |
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Definition
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Term
|
Definition
block fast Na channels decr. cardiac contractility |
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Term
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Definition
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Term
|
Definition
Hepatic met renal excretion CROSSES placenta! |
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Term
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Definition
CHF (exacerbate/precip) 2X mortality in tx of asymptomatic v-tach w/ MI |
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Term
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Definition
block fast Na channels weak BB L-type channel blockade |
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Term
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Definition
sustained vtach supravent tachy |
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Term
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Definition
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Term
| propafenone should NOT be used in pts w/ |
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Definition
CHF, heart block, and conditions exacerbated by BB |
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Term
| drug interaction of propafenone |
|
Definition
decr dig, warfarine, propranolol, metoprolol |
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Term
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Definition
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Term
| phenytoin is similar to what drug |
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Definition
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Term
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Definition
decr automaticity incr AV node conduction shorten APD and ER in His/Perk/Vent |
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Term
|
Definition
reduce rt of phase 4 depolarization in ectopic pacemakers V dysrythmias w/ dig toxicity-> 2nd choice after lidocaine |
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Term
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Definition
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Term
|
Definition
sedation ataxia nystagmus GINGIVAL HYPERPLASIA |
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Term
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Definition
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Term
|
Definition
blocks Na channels in vtach and ectopic rts depress conduction and prolong refractory of AV node |
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Term
moricizine similar to what classes of drugs |
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Definition
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Term
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Definition
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Term
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Definition
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