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Anti-Dysrhythmics
pharm II 2
32
Pharmacology
Graduate
10/04/2012

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Cards

Term
Supraventricular arrhythmias
Definition
Sinus bradycardia, sinus tachycardia, paroxysmal supraventricular tachycardia, atrial fib, atrial flutter
Term
Ventricular arrhythmias
Definition
Premature ventricular contractions, VT, VF
Term
Class I agents
Definition
Sodium Channel blockers
Term
Class 1A
Definition
procainamide, quinimide, disopyramide
Term
Class 1A MOA
Definition
imtermediate potency blockade Na channels, slows phase 0, slows conduction, prolong repolarization
Term
Class 1B
Definition
Lidocaine, Tocainide, Mexiletine
Term
Class 1B MOA
Definition
least potent blockade Na channels, shortens phase 3 repolarization, treat v-tach, not effective for Supraventricual arrhythmias
Term
Class 1C
Definition
flecainide, propafenone
Term
Class 1C MOA
Definition
most potent blockade Na channels, markedly slows phase 0 depolarization, slows conduction, not safe,
Term
Procainamide (Pronestyl, Procan SR)
Definition
Class 1A sodium channel blocker, 3rd string drug, v-tach. AE- Lupus syndrome
Term
Lidocaine (Xylocaine)
Definition
Class 1B sodium channel blocker, v-tach (been replaced), extensive first pass metabolism
Term
Circumoral Paresthesias, Tinitus
Definition
Lidocaine AE
Term
Flecainide (Tambocor)
Definition
Class 1C Na blocker, prevention of A- fib and flutter, and life threatening v-tach--> Mortality
Term
Propafenone (Rythmol)
Definition
class 1C Na blocker, beta blocking properties; for life threatening V tach
Term
Class II dysrhythmias
Definition
Beta blockers
Term
Beta blocker in dysrhythmias
Definition
diminish phase 4 depolarization, depress automaticity, prolong AV conduction, decrease HR and contractility
Term
DOC for a-fib, flutter
Definition
Beta blocker in dysrhythmias
Term
Class III dysrhythmias
Definition
Potassium channel blockers
Term
Potassium channel blockers
Definition
Amiodarone, Ibutilide, Dofetilide
Term
Potassium channel blockers MOA
Definition
prolong duration of action potential without altering phase 0 depolarization
Term
Amiodarone (Cordarone)
Definition
lots of actions, main prolong action potential and refractory period; antianginal and antiarrhythmic activity. DOC in PVT/V-fib and pt w. HF. Long t1/2
Term
Pulmonary fibrosis, liver toxicity, skin discoloration, torsades de pointes, drug interactions
Definition
Amiodarone AE
Term
Ibutilide (Corvert), Dofetilide (Tikosyn)
Definition
class III Agent, used to terminate atrial fib, controls atrial rhythm.
Term
Class IV dysrhythmias
Definition
Calcium channel blockers
Term
Calcium channel blockers MOA for dysrhthmias
Definition
decrease rate of phase 4 depolarization, slow AV conduction, better for Atrial
Term
Verpamil (isoptin, Calan)
Definition
Class IV, Ca blocker
Term
Diltiazem (Cardizem)
Definition
Class IV, Ca blocker
Term
Class V dysrhythmias
Definition
Digoxin, Adensoine, Atropine
Term
Digoxin
Definition
Parasympathomimetic- control ventricular response rate in afib- enhance vagal tone, direct AV block-- slow conduction rate. Drug interactions!
Term
Adenosine (Adenocard)
Definition
vagomimetic- slows conduction rate, refractory period, and AV automaticity. DOC to stop acute supraventricular tachycardia
Term
DOC to stop acute supraventricular tachycardia
Definition
Adenosine
Term
Atropine
Definition
blocks vagus nerve on heard, increase sinuse rate and av conduction--> for bradycardia
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