Term
Tricyclic antidepressants(TCAs)
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Definition
inhibit the reuptake of norepinephrine and serotonin.
ex:amitriptyline(elavil), nortriptyline(pamelor)
Must take dose for 10-14 days before they begin to work. Full effects not seen for 4-8 weeks.
Dosage should always start low initially and should be increased gradually. |
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Term
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Definition
Anticholinergic actions(dry mouth, blurred vision, tachydcardia, constipation, urinary retention.)
Orhtostatic hypotension, and sedative effects.
LETHAL in overdose: Toxicity may lead to dysrhythmias, tachycardia, myocardial infarction. |
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Definition
| Flu like symptoms if stopped suddenly. Rise slowly. Gum and candy for dry mouth. |
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Term
| Selective serotonin reuptake inhibitors.(SSRIs) general info |
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Definition
prevent serotonin from reuptake in pre-synaptic neuron. Faster onset of action than TCAs, better side effect profile.
Should not be taken with MAOI's(or within 14 days of discontinue)
examples: Prozac, zoloft, Paxil, Celexa, Lexapro. |
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Definition
| SEXUAL DYSFUNCTION, sleep disturbances, nauseated, weight gain, |
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Definition
overactivation of the central serotonin receptors. hyperactivity,anxiety, insomnia, increased temp, increased BP, increased pulse, delirium.
Interventions:discontinue SSRI's. use serotonin blocker. cooling blankets, anticonvulsants. |
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Definition
| All take 4-6 weeks for full therapeutic effect. after 1-2 weeks may see increase in energy level. Negative side effects can be felt first-Watch for suicidal ideation. goal is to improve sleep, less fatigue, more emotional control. |
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| Monoamine Oxidase Inhibitors |
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Definition
Prevent destruction of monoamines(serotonin, norepinephrine, dopamine)
ex:Marplan, Nardil, Parnate
Low tyramine diet(avoid aged foods including cheese and meats, wine.) and avoid OTC reactions(cough medicines) |
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Definition
| HYPERTENSIVE CRISIS(severe HA,fever,stiff neck, severe nose bleeds) sedation, orthostatic hypostension, weight gain, sexual dysfunction. |
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Definition
| Used for smoking cessation, acts on dopamine. Do not take with seizure disorder. s/e: Priaprism-prolonged, painful erection. |
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