The first beta-lactam antibiotic discovered

it still has good activity against syphilis and certain gram positives like streptococcus

Penicillin

G form given IV

V form taken PO

An aminopenicillin that inhibits cell wall synthesis

extends spectrum of pencillins to cover gram-negative organisms like proteus

is used in combo w/other drugs for H. pylori

binds to and inactivates many beta-lactamases

confers additional activity most notably against MRSA and B. fragilis; also extends gram-negative spectrum

There are many generations of this beta-lactam bactericidal antimicrobials

later generations have better gram-negative coverage and less gram-positive activity

The prototype of the carbapenem family, it has the broadest spectrum of activity and is highly beta-lactamase resistant

has empiric coverage of virtually all bacteria

a glycopeptide antimicrobial that binds w/high affinity to the D-alanyl-D-alanine portion of cell wall precursors and prevents polymerization of peptidoglycans

bactericidial for dividing gram POSITIVE bacteria

This tetracycline antimicrobial is bacteriostatic,

it reversibly binds to the 30S ribosomal subunit

it is used for rickettsial, chalmydial, spirochete infections; malaria prophylaxis; atypical pneumonia

This macrolide antimicrobial inhbiits protein synthesis by binding 50S subunit

it is also a motilin receptor agonist

used for: CA-penumonia, strep/pneumococcal infections in penicillin allergic patients

This drug binds to 50S subunit and inhibits the petidyl transferase step; it is bacteriostatic

used for gram + cocci, anaerobes

binds the 50S subunit blocking peptidyl transferase, is bacteriostatic and inhibits mitochondrial protein synthesis in bone marrow

causes aplastic anemia and gray baby syndrome

This bacteriostatic antimicrobial is a structural analog of PABA that antagonized dihydropteroate synthetase

is synergistic w/trimethoprim

used for CA-MRSA, PCP, toxo, nocardia, UTIs

this DHFR inhibitor is used in compination w/sulfonamide

can cause megaloblastic anemia

This bactericidal fluoroquinolone inhibits bacterial topoisomerase and DNA gyrase

has a wide range of activity against gram-negatives and some activity against gram positives, but very little activity on anaerobes

active against mycobacteria/atypicals

this drug produces cytoxotic intermediates that react w/DNA, protein, bacterial membranes

used for anaerobic infections, c.difficle, protozoan parasites

can cause disulfram-like reactions w/ethanol

bactericidal agent that inhibits DNA-dependent RNA polymerase of mycobacteria by binding to B-subunit

used for Tuberculosis, M.leprae, eradication of H.influenza or N.meningococcus carriage

A structural analog of PABA that competitively inhibits dihydropteroate synthase

used for treatment of PCP or M. leprae

4th generation cephalosporin

good activity against gram+ including S. aureus

good activity against gram - including Pseudomonas

1st generation cephalosporins (3)

good gram +, limited gram - activity

also called "monobactam" it can be used in patients w/penicilin hypersensitvity

used for gram negative UTIs

this drug only has gram positive activity

it can cause red man syndrome or nephrotoxicity