Term
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Definition
Anthelmintic class - inhibit microtubule formation, so worm starves
-mostly nematodes > cestodes/trematodes
-GI stages / adults > extra-GI stages / developing stages
e.g. thiabendazole, oxfendazole, albendazole, triclabenazole |
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Term
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Definition
A benzimidazole anthelmintic - inhibit microtubule formation, so worm starves
-nematodes only
-high water solubility |
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Term
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Definition
A benzimidazole anthelmintic - inhibit microtubule formation, so worm starves
-nematodes and cestodes, not trematodes
-low water solubility - admin as prodrug
febantel-->febendazole-->oxfendazole |
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Term
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Definition
| Prodrug of oxyfendazole (a benzimidazole anthelmintic) |
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Term
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Definition
A benzimidazole anthelmintic - inhibit microtubule formation, so worm starves
-nematodes, cestodes and trematodes
-low water solubility - admin as prodrug
netobimin-->albendazole |
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Term
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Definition
benzimidazole anthelmintic - inhibit microtubule formation, so worm starves
-trematodes only (unusual - reverse spectrum) |
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Term
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Definition
Imidazothiazoles e.g. levamisole
Tetrahydropyrimidines e.g. morantel, pyrantel
-Anthelmintics - cholinergic stimulants causing flaccid paralysis
-nematodes only |
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Term
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Definition
Part of 2-LM anthelmintic class:
-cholinergic stimulant causing flaccid paralysis
-nematodes only
e.g. levamisole |
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Term
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Definition
An imidazothiazole of 2-LM anthelmintic class:
-cholinergic stimulant causing flaccid paralysis
-nematodes only, includes lungworm |
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Term
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Definition
Part of 2-LM anthelmintic class:
-cholinergic stimulant causing flaccid paralysis
-nematodes only
e.g. morantel, pyrantel |
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Term
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Definition
A tetrahydropyrimidine of 2-LM anthelmintic class:
-cholinergic stimulant causing flaccid paralysis
-nematodes only |
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Term
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Definition
A tetrahydropyrimidine of 2-LM anthelmintic class:
-cholinergic stimulant causing flaccid paralysis
-nematodes only (slighlty wider spectrum than other tetrahydropyrimidines) |
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Term
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Definition
Anthelmintic cless - disrupt chloride channels leading to flaccid paralysis (glutamate and GABA-linked Cl channels)
-active against all stages of ~all nematodes
e.g. ivermectin, milbemycins |
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Term
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Definition
An avermectin anthelmintic - disrupts chloride channels leading to flaccid paralysis (glutamate and GABA-linked Cl channels)
-active against all stages of ~all nematodes |
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Term
| Macrocylic lactone derivatives |
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Definition
Drugs of the 3-AV anthelimintic class
i.e. avermectins and milbemycins |
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Term
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Definition
Drugs of the 3-AV anthelimintic class
-disrupt chloride channels leading to flaccid paralysis (glutamate and GABA-linked Cl channels)
-active against all stages of ~all nematodes
e.g. milbemycin, moxidectin |
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Term
| Amino-acetonitrile-derivative (AD-4) |
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Definition
Anthelmintic class - activates nematode specific AchR subunits - worm paralysis
-nematodes only and not eggs |
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Term
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Definition
| Anthelmintic - activates GABA-operated chloride conductance on neuronal and musl. cells - flaccid paralysis (worm may be passed in infective in faeces) |
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Term
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Definition
Anthelmintic -acts on protein involved in release of neurotransmitter in presyn. terminal of NMJ - musc. paralysis
-nematodes, not eggs |
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Term
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Definition
| Anthelmintic against trematodes - disrupts Ca++ homeostasis -incr. IC Ca++ so muscle spasm, vacuolation and incr. perm. of tegument |
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Term
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Definition
Anthelmintics active against trematodes (unusual)
-block oxidative phosphorylation so interfere w. E supply
e.g. Nitroxinil, Closantel |
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Term
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Definition
Substituted phenol anthelmintics - active against trematodes (unusual)
-block oxidative phosphorylation so interfere w. E supply |
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Term
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Definition
| A sulphonamide active against some trematodes (normally antibacterial) |
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Term
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Definition
| Banned anthelmintics - acts as anticholinesterases so incr. ACh at NMJ and neuronal synapse and so paralysis |
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