Term
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Definition
Antihypertensive Stimulates Adrenergic receptors in the CNS Lowers SNS tone--decreases BP likely stimulates inhibitory center |
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Term
Sweat Gland SNS Postganglion Signal |
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Definition
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Term
What stimulates dilation of skeletal muscle vasculature? |
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Definition
Beta 2 receptors from circulating epinephrine |
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Term
Pathway from Tyrosine to Epinephrine |
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Definition
Tyrosine-->DOPA-->Dopamine-->NE-->Epinephrine |
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Term
What is the RLS of EPI synthesis from Tyrosine? |
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Definition
Tyrosine-->DOPA via dopamine hydroxylase |
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Term
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Definition
Competitive inhibitor of tyrosine hydroxylase Treats pheochromacytoma (catecholamine producing tumor of the adrenal medulla) |
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Term
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Definition
Enzyme catalyzing conversion of DOPA to Dopamine Aromatic AA decarboxylase enzyme |
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Term
Dopamine-Beta-Hydroxylase |
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Definition
Enzyme for Dopamine to Norepinephrine conversion |
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Term
Phenylethanolamine-N-methyltransferase |
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Definition
Converts NE to EPI In Adrenal Medulla |
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Term
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Definition
A compound that enters presynaptic storage vesicles and replaces the normal neurotransmitter. |
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Term
2 druges which interferewith storage and release of norepinephrine release from nerve terminals |
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Definition
Guanethidine and Reserpine |
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Term
Guanethidine's effect on BP |
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Definition
Initially short term increase (Not seen clinically, however, because it only occurs via IV bolus, and that's not done with Guanethidine) Then long term decrease |
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Term
Guanethidine Side Effects: (5) |
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Definition
Orthostatic Hypotension Excessive GI stim (unopposed PSNS) Inhibition of Ejaculation Pheochromocytoma especially sensitive No CNS effect (can't cross BBB because too polar) |
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Term
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Definition
Decreases Blood Pressure via inhibition of ATP dependent NE/Dopamine uptake carrier in vesicles NE can't get into the vesicles--not displaced, it just runs out |
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Term
Is Reserpine Lipid or Water soluble? Side effects? (4) |
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Definition
Lipid soluble--enters CNS: Sedation Lethargy Nightmares Depression |
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Term
How does cocaine function to stop adrenergic nerve terminals? |
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Definition
It blocks reuptake of NE into presynaptic terminal. |
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Term
How do Tricyclic Antidepressants (TCAs) work? |
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Definition
It blocks reuptake of NE into presynaptic terminal. |
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Term
What is the primary mechanism of termination of the adrenergic signal? |
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Definition
Reuptake of catecholamines by the presynaptic nerve terminal. |
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Term
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Definition
Enzyme that metabolizes catecholamines after uptake. Mitochondrial enzyme that is widely distributed in body tissues. |
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Term
COMT Catechol-O-methyltransferase |
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Definition
Widely distributed Cytoplasmic enzyme. High concentrations in kidney and liver. |
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Term
Dopamine's metabolite in urine |
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Definition
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Term
Epi and NE urinary metabolites |
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Definition
3-methoxy-4-hydroxyphenylglycol (MHPG) and 3-methoxy-4-hydroxy-mandelic acid (VMA) |
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Term
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Definition
From use of MAO inhibitors from foods high in tyramine tyramine is normally broken down by MAO, but with the inhibitor present, it can't be broken, down, so the tyramine acts as a sympathomimetic. 15-20 documented deaths. |
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Term
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Definition
EPI>NE>>ISO Vasoconstriction Contraction of Uterus Contraction of Nictitating Membrane Pupillary Dilation GI Inhibition |
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Term
Beta Receptors--order of epinephrine, NE, and ISO strengths |
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Definition
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Term
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Definition
Cardiac Stimulation Renin Secretion by JG cells. NE, EPI and ISO all utilized. |
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Term
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Definition
Vascular Dilation Bronchiolar Relaxation Iso and Epi: NO NE! |
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Term
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Definition
Parent compound from which sympathomimetic drugs are derived |
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Term
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Definition
Direct alpha sympathomimetic |
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Term
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Definition
Direct alpha sympathomimetic |
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Term
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Definition
Direct alpha sympathomimetic |
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Term
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Definition
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Term
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Definition
Beta 2 agonist (bronchodilator) |
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Term
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Definition
Beta 2 agonist (bronchodilator) |
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Term
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Definition
Beta 2 agonist (bronchodilator) |
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