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Anit-viral HIV Drugs
Side effects
49
Pharmacology
Professional
04/21/2013

Additional Pharmacology Flashcards

 


 

Cards

Term
Class of drugs you see Lactic Acidosis and Hepatic Steatosis
Definition
NRTI's
Term
Hyperpigmentation/skin discoloration
Definition
Emtricitabine (emtriva) (FTC)
Term
Fanconi Syndrome, Osteomalacia, DECREASED BMD
Definition
Tenofovir (Viread) (TDF)
Term
Should NOT use with Lamivudine (3TC)
Definition
Emtricitabine
Term
Should NOT use with Emtricitabine (FTC)
Definition
Lamivudine
Term
Can cause acute HBV exacerbation in co-infected
Definition
Lamivudine, Emtricitabine, Tenofovir
Term
Increased risk of MI
Definition
Didanosine(ddl) and Abacavir (ABC)
Term
Only NRTI that is a problem in renal patients AND hepatic
Definition
Abacavir (ABC)
Term
MUST take this NRTI on an empty stomach unless you take with UTF
Definition
Didanosine (ddl)
Term
Do NOT use with Stavudine (d4t)
Definition
Didanosine (ddl) and Zidovudine (AZT)
Term
Do NOT use with didanosine or Zidovudine
Definition
Stavudine (d4t)
Term
Peripheral Neuropathy, Lipoatrophy, Insulin resistance/DM, Hyperlipidemia
Definition
Zidovudine (AZT), Stavudine (d4t), Didanosine (ddl)
Term
Can cause optic neuritis, NRTI
Definition
Didanosine (ddl)
Term
Bone marrow suppression, NRTI
Definition
Zidovudine (ZDV)
Term
Take with food, NNRTI
Definition
Etravirine (ETR), Rilpivirine
Term
Tablet can be dissolved in water NNRTI
Definition
Etravirine (ETR)
Term
Higher incidence of rash (SJS, TEN) and incidence of hepatotoxicity
Definition
Nevirapine (NVP)
Term
Autoinducer, NNRTI
Definition
Nevirapine (NVP)
Term
Should not really use in females with CD4 > 250 and Males with a CDF > 400
Definition
Nevirapine (NVP)
Term
INCREASED rate of virolgoic failures when HIV VL > 100,000 or CD4 < 200
Definition
Rilpivirine (RPV)
Term
Nail pigmentation issues
Definition
Zidovudine (ZDV)
Term
NRTI BID dosing
Definition
Stavudine (d4t), Zidovudine (ZDV)
Term
Teratogenic, avoid in women that are pregnant
Definition
Efavirenz (EFV)
Term
NNRTI that should NOT be used with PPI without spacing it
Definition
Rilpivirine (RPV)
Term
Drug class has HIGHER genetic barrier to resistance than NNRTIs and INSTIs (need more virus mutation)
Definition
PIs
Term
Drug class causes Fat maldistribution, INCRASED bleeding time in hemophiliacs, Dyslipidemia and issue problems
Definition
PIs
Term
Indirect hyperbilirubinemia (jaundice or scleral icterus)
Definition
Atazanavir (ATV)
Term
Space dosing when using acid suppressing agents , PI
Definition
Atazanavir (ATV)
Term
Neprholithiasis, Cholelithiasis AND PR prolongation
Definition
Atazanavir (ATV)
Term
Taste perversion
Definition
Ritonavir (RTV)
Term
Preferred PI's for initial treatment
Definition
Ritonavir and Atazanavir
Term
Contains Sulfonamide moiety
Definition
Darunavir (DRV), Tipranavir, Fosamprinavir (FPV)
Term
MUST NEVER be given without a booster (Ritonavir)
Definition
Darunavir (DRV)
Term
Can be given unboosted in ARV naive patients
Definition
Fosamprenavir (FPV)
Term
PR and QT prolongation with Significant dyslipidemia (mainly TG)
Definition
Lopinavir/Ritonavir (kaletra)
Term
Can dissolve tablet in water (PI)
Definition
Nelfinavir (NFV)
Term
Cause significant diarrhea
Definition
Nelfinavir (NFV)
Term
Highest pill burden of PIs
Definition
Saquinavir (SQV)
Term
Only PI that is NEVER boosted with Ritonavir (RTV)
Definition
Nelfinavir (NFV)
Term
Hepatotoxicity, drug induced hepatitis and Fatal/Non fatal intracranial hemorrhage
Definition
Tipranavir (TPV)
Term
This class has fewer drug interactions than PI, NNRTI, MVC or EVG regimens
Definition
Raltegravir (RAL)
Term
Potential for increase in Cr Kinase, myopathy and Rhabdomyolysis
Definition
Raltegravir (RAL)
Term
Integrase inhibitor that requires food
Definition
Elvitegravir
Term
Only recommended in patients with a baseline CrCl > 70
Definition
Elvitegravir
Term
Primarily only used in salvage therapy
Definition
Enfuvirtide (T-20) Fusion inhibitor
Term
Must be given Sub-Q dosing
Definition
Enfuvirtide (T-20)
Term
Local injection site reaction in 100% of patients
Definition
Enfuvirtide (T-20)
Term
CCR5 Antagonist
Definition
Maraviroc (MVC)
Term
Can ONLY give in patients that have virus using CCR5 or R5 virus, can NOT be used in anything else even if mixed receptor virus
Definition
Maraviroc (MVC)
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