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Animal Physiology
Unit one of animal phys
73
Biology
Undergraduate 4
10/10/2013

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Term
Food------?--------> ATP (4 steps)
Definition
1. ingestion
2. digestion
3. absorption
4. metabolism
Term
Most abundant form of organic carbon on earth
Definition
Cellulose
Term
Herbivores
Definition
Foregut (cows)
Hindgut (horses) Eek
Term
Mechanical Digestion (mouth)
Definition
Mastication
Tongue
Term
Chemical Digestion (mouth)
Definition
Starch---(salivary amylase)---->maltose+maltotriose
Triglycerides---(lingual lipase)--->monoglyeride
Term
Ingestion Strategies
Definition
Grazer (Volume over Quality)
Browser (Quality over Volume)
Filter Feeder
Term
Stomach pH
Definition
pH:2-4. From HCL excretion from parietal cells signaled by gastrin and histamine
Term
Stomach Mucus Layer
Definition
Excreted by goblet cells. Contains Bicarb. Signaled by prostaglandin ( Prostaglandin can be made inactive by anti inflammatory drug)
Term
Stomach Endopeptidase?
Definition
Pepsin: inactive form, pepsinogen, present in stomach and undergoes conformational change due to pH decrease. Hydrolyzes peptide bonds. Pepsinogen excreted by chief cells.
Term
Stomach mechanical Digestion
Definition
Churning b/c rugae
Term
Ruminant Stomachs
Definition
1. Rumen ( Breakdown of cellulose)
2. Reticulum (sorting of fibers)
3. Omasum (water absorption)
4. Abomasum (glandular stomach)
Term
Rumen Cellulose Pathway
Definition
Cellulose-->Glucose--->pyruvate--->Volatile Fatty Acids--->Acetyl COA
Term
Volatile Fatty Acids
Definition
1. Propinate
2. Acetate
3.Butyrate
Primary energy source for the ruminant
Term
Reticulum
Definition
3 Way sorting
1. Too long fibers----> sent back to mouth for mastication
2. Needs more work----> back to rumen
3. Good Fibers--->omasum
Honey comb shape.
Term
Omasum Function
Definition
Water Absorption. Very High surface Area
Term
Small intestine
Definition
Begins at pyloric sphincter which is opened by CCK signal. Duodenum--->jejunum--->ilium.
Term
Gallbladder
Definition
Excretes bile from bile duct. Excretion is signaled by CCK at the same time as Pyloric Sphincter
Term
Bile Content
Definition
1. Bile Salt } - pH buffer
2. Lecithin | 1-3 emulsify lipids
3.Cholesterol }
4. Billirubin
5. Bicarb
Term
Duodenum
Definition
pH change to 6-7 b/c bile salts and bicarb
Term
Pancreas
Definition
Contains inactive proteolytic enzymes (trypsinogen, chymotrypsinogen, proelastase, procarboxypeptidase)
Catalyze hydrolysis of Proteins. Contains Trypsin inhibitor to prevent premature activation (pancreatitis). Amylase also present in duodenum which fxns same.
Term
Enzyme Activation (duodenum)
Definition
Trypsinogen activated by enteropeptidase (in duodenum). Once activated Trypsin can activate itself as well as the other pancreatic enzymes.
Term
Pancreatic Enzyme FXN
Definition
1. Trypsin- Basic AA
2. Chymotrypsin-Aromatic AA
3. Elastase- Small AA
4. Carboxypeptidase- C-terminal AA -->dipeptide results
Term
Glucose and AA Pathway through SMALL INTESTINE
Definition
Villi +microvilli increase surface area and contain dipeptidases(for aa), and disaccharideases (for glucose). AA and Glucose absorbed into villi into capillary---> hepatic protal vein--->liver(filter)--->vena cava.
Term
Small intestine Pathway ( tri/monoglycerides)
Definition
Combine with fatty acids and protein to form lipoprotein that is absorbed into lacteal in the villi. Lacteal is a lymph vessel that dilutes lipoproteins into the the vena cava.
Term
Sugars
Definition
Maltose= Glucose+Glucose
Sucrose= Glucose +fructose
Lactose= Glucose + Galactose
Term
Pathway into Large Intestine
Definition
Through Ileocecal valve and into the cecum. Through cecum and into colon then into the rectum,
Term
Fecal Storage FXN
Definition
1. Water Absorb
2. Normal Flora Maintenance
3. Vitamin K synthesis.
Term
Cardiomyocyte
Definition
Cardiac Muscle Cell. Intercalated (pacemaker), coupled. Myogenic. One nuclei. NO TETANUS
Term
Cardiomyocyte Cell Polarity
Definition
K+Na+ATPase pumps 2K+ into cell and 3Na+ out of cell giving - charge (electrogenic). @ -70 leaky channels start to depolarize slowly. @-40 voltage gated sodium channels open which quickly depolarize cell. @+20 Na goes refractory, and VG K+ channels open to re polarize cell
Term
Positive Chronotrope
Definition
Epinephrine- increases Na+ conduction, decreases K+ conduction. Increases Heart Rate
Term
Negative Chronotrope
Definition
Acetyl Choline-Increases K+ conduction, decreases Na+ conduction. decreases Heart Rate
Term
SA NODE
Definition
first to depolarize and sets the pace for the rest of the cells
Term
AV node
Definition
second to depolarize and picks up signal of SA node to depolarize ventricles
Term
Heart Depolarization
Definition
SA node depolarizes and the depolarization spreads through the r/l atrium. AV node picks up signal of SA node and sends depolarization down BUNDLE OF HIS and out into the PERKINJIE FIBERS which in turn depolarizes the ventricles.
Term
Fermentation
Definition
By-products=CO2+Methane
Horse-Burp(hindgut)
Cow-Fart (foregut)
Term
ECG + Heart Depolarization
Definition
Before p-wave the SA node is depolarizing. At P wave the atria depolarize. At QRS the ventricles depolarize (and atria repolarize). T wave= ventricles repolarize.
Term
Xylozine
Definition
Alpha 2 agonist. Gaps occur where R wave would normally occur.
Term
Calcium for Muscle contraction
Definition
Calcium removes troponin and tropomyosin from actin and myosin allowing muscle to contract. Ca+ can come from outside of the cell or from the sarcoplasmic reticulum.
Term
Blood flow Through Heart
Definition
vena cava-->RA-->RAV-->RV-->pulmonic valve-->pulmonary artery-->lungs-->pulm. vein--> LA-->LAV-->LV--->aortic valve--->aorta
Term
Frank Starling
Definition
If volume entering the ventricles increases then so too will the volume out. Same with less blood in.
Term
1st Heart Sound
Definition
AV valves close as ventricles depolarize and eject blood. At QRS
Term
2nd Heart Sound
Definition
Aortic and pulmonic valves close b/c high pressure in aorta and pulm. artery, and low pressure in ventricles. At T-Wave
Term
Systole
Definition
Contraction (systolic bp)
Term
Diastole
Definition
Relax (diastolic Bp)
Term
Isobaric Contraction
Definition
Pressure in ventricles is high enough to open semi lunar valves.
Term
Heart Murmurs
Definition
Turbulence
-Blood through small opening
-Leaky valve
-Narrowing (stenosis)
Term
Blood flow
Definition
Laminar Flow - highest velocity in the middle of vessel.
--->
----->
------->
----->
--->
Term
Pressure + Tension in Blood Vessels
Definition
Is p1=p2 then the vessel with a larger diameter will have higher tension. This means that larger vessels need thicker walls.
Term
Aneurism
Definition
Sudden increase in vessel diameter which increases tension in that part.
Term
Cardiac Output
Definition
Volume of blood ejected by L ventricle in one minute (l/min)
CO=SV*HR
Term
Stroke Volume (SV)
Definition
(Blood ejected w/ one contraction)
Term
Positive Inotropes
Definition
Increase Stroke Volume (intracelular calcium increase)
Term
Hemoglobin FXNs
Definition
O2 transport, CO2 Transport, Heat Transport, H2O, Coagulation,
Term
O2 Transport (hemoglobin)
Definition
3% dissolved in plasma, the rest binds cooperatively to hemoglobin. High pressure in the lungs, low pressure in the tissue=high affinity in the lungs, low affinity in the tissue.
Term
Hemoglobin in the Tissue
Definition
low pH (more protons), more CO2, High temperature, 2,3 BPG.
Term
CO2 Transport
Definition
Can be bound to hemoglobin, dissolved in plasma, or by -HCO3,
Term
Hemoglobin in the lungs
Definition
High O2 affinity, less BPG presence. Higher pH (fewer protons)
Term
Hemoglobin @ high Altitude
Definition
Low O2 affinity after time to adapt as BPG increases with lower oxygen pressure, but tissues can pull more oxygen when there is lower affinity there by acclimating to the change.
Term
Lung Organization
Definition
Trachea w/ cartilage rings-->Carina-->primary bronchi-->2 bronchi--(lung lobes 3 on each side)--> 3 bronchi--> 1bronchioli-->2bronchioli--->3bronchioli-->avioli.
Term
Inspiration
Definition
External intercostals contract (maybe with diaphragm) . This expands volume in the thoracic cavity and therefore drops pressure in the cavity (below Atmospheric), so air fills the lungs.
Term
Exhilation
Definition
internal intercostals relax decreasing volume in the thoracic cavity and increasing pressure thus pushing air out of the lungs. Can occur forcefully w/ contraction from internal intercostals.
Term
Parietal Pleura
Definition
Mucus lining around the inside of the thoracic cavity prevents friction from occurring between lungs and cavity walls.
Term
Visceral Pleura
Definition
Mucus lining around the outside of the lungs. FXN same as parietal pleura
Term
Ventilation Perfusion mismatching.
Definition
avioli that are not in use by the lungs (broncho constrict) will not receive O2, and those that are open (broncho dilate) will receive O2.
Term
Why Do We need Lungs
Definition
WE ARE BIG. High Surface area for O2 absorption.
Term
Skeletal Muscle
Definition
Variable mitochondria, regular cytoskeleton, can be very long , lots of nuclei, NOT COUPLED, Ca+ comes from sarcoplasmic reticulum. Can have tetanus.
Term
GI Smooth Muscle
Definition
low mitochondria, scattered cytoskeleton, one nuclei, coupled, Ca comes in extracellular, myogenic
Term
Motor Unit
Definition
A motor neuron and the muscle cell that it inervates
Term
Increase Muscular Force
Definition
1. Increase number of axons firing (amplitude) also known as recruitment
2. Increase frequency of firing (summation)
Term
Skeletal Muscle Cell (contract)
Definition
NEEDS ACETYL CHOLINE TO CONTRACT. @ -40 VG Na+ Open, Ca+ comes in from SR to remove troponin/tropomyosin
Term
Skeletal Muscle Cell (relax)
Definition
K+ voltage gated channels open @ +20, Ca+ goes back to SR, Actin/myosin let go/relax, troponin and tropomyosin rebind in absence of Ca++
Term
Nicotinic Acetyl Choline Receptor
Definition
Binding place for Motor axon. Releases Acetyl Choline
Term
Skeletal
Definition
Depolarization slightly proceeds contraction, and contraction lasts longer than depolarization which is how summation can occur.
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