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*how we think about geetic behavior of a pop * help derive genetic comp of a pop |
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f(RR)= N(RR)/N f(Rr)= N(Rr)/N f(rr)= N(rr)/N
N(xx): # ind w/ xx N: total # ind |
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f(R) = N(R)/2N f(r) = N(r)/2N
N(x): (#ind XX)(2) + (#ind Xx)(1) |
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Relationship between allele and geno freq |
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GIVEN GENO, FIND ALLELE *if know geno, know allele b/c for a given geno freq, only 1 allele freq work
GIVEN ALLELE, FIND GENO *if know allele freq, DONT know geno b/c lots of geno freq conform to 1set of allele *have lots of geno freq that can conform to allele freq *have multiple ways to get allele freq so dont know for sure |
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quantifying our belief in the possible outcomes of a future event |
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the outcome of 1 won't affect the outcome of another |
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JOINT P FOR INDEPENDENT EVENTS *apply AND rule
MUTUALLY EXCLUSIVE *1 outcome happens so the other cannot happen @ the same time *apply OR rule |
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prediction of the relationship between allele and geno freq (when given allele, predicts geno freq)
*important b/c we can make predictions about breeding strats and see if they're successful *useful when know geno b/c helps make predictions for how well a breeding plan will work |
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f(RR) = f(R)^2 f(Rr) = 2f(R)f(r) f(rr) = f(r)^2
f(R)= p f(r)= q
f(RR) = P f(Rr) = H f(rr) = Q
P=p^2 Q= q^2 H= 2pq
p+q=1 p^2 + 2pq + q^2 = 1 P + H + Q = 1 |
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*human pop conforms to HWE b/c we assume random mating to a specific locus |
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particular alleles are removed or enriched in a pop |
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CULLING NOT EFFECTIVE *when ind is in a low freq in pop *only eliminiating a small number of 'e' alleles and there are many in hetero state masked by dom E *vast majority in hetero, and cant select against it in hetero state *very difficult to remove a recessive allele w/ pheno selection |
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*P of producing a delterious allele w/ a relative is high *ind mate w/ relatives and prod offspring that are less fit b/c inc chances of pairing deleterious alleles (b/c relatives share alleles) |
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*if you have recessive allele @ low freq, it only becomes present in hetero state, so cant select against w/ pheno selection *@ low freq, most receessive deleterious alleles are in hetero state and cacnt be selected against |
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* w * an organisms ability to contribute to the next gen *takes into account survival and repro state
w= 1 <-- geno w/ highest freq |
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*how much a particular geno is selected against *strength of selection agaisnt a geno allows to describe amore broad range of scenarios about a geno relative contrib to next gen *influence how much allele freq changes in a single gen of selection |
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bringing an allele to the freq =1 (meaning only allele present in a pop) |
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Important Factors that influence how much an allele freq changes in a single gen of selection |
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1) SELECTION COEFF * stronger seection --> more of a freq allele change
2) DOMINANCE PATTERN
3) STARTING ALLELE FREQ |
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Graphing freq of advantageous alleles over time |
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COMPLETELY DOM A+ ALLELE * arises in hetero state & rises in freq quickly but never goes to fixation b/c cant purge non-adv allele
COMPLETELY RECESSIVE A+ ALLELE *if a recessive mutation arises its in hetero state & cant be selected for quickly but once it does, it eventually reaches fixation
NO DOMINANCE *rises quickly and reaches fixation |
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