Term
|
Definition
Enhance GABA, glycine
Block excitatory
Block NMDA glu |
|
|
Term
|
Definition
| Very soluble drugs have a slower onset |
|
|
Term
N2O
CV
Resp
CNS
MM
Renal
GI/Liver |
|
Definition
Small effect
No adverse CNS
NO Mm relax
No renal tox
Post op n/v
*excellent analgesic |
|
|
Term
Halothane
CV
resp
CNS
Mm
Renal
G/L |
|
Definition
Dec BP, CO, HR and rhythm disturbances
Mech vent, DD
Inc ICP
Uterine relax
Dec renal funct
*Heptatitis |
|
|
Term
Enflurane
CV
resp
CNS
MM
Renal
G/L |
|
Definition
Dec BP, CO, *SVR. Rhythm dist
Yes
*Tonic clonic movements, avoid epilepsy
Great relaxation
Dec renal funct
Hepatitis rare |
|
|
Term
Isoflurane
CV
Resp
CNS
MM
Renal
G/L |
|
Definition
Dec BP, reflex inc HR.* coronary vasodilation
Mech vent, irritating
Inc ICP
Great relaxation
Some renal issues
No hepatotox |
|
|
Term
Desoflurane
CV
Resp
CNS
MM
Renal
G/L |
|
Definition
Dec BP, SVR, Inc HR
Mech Vent
None
No MH
No
No |
|
|
Term
Sevoflurane
CV
Resp
CNS
MM
Renal
G/L |
|
Definition
Dec BP, SVR
*Non irritating
no
no
Plasma F has caused tox before |
|
|
Term
Barbituates
MOA
PKs
CNS
CV
Resp
MM
Renal/Liver
Status |
|
Definition
Thipental, Methohexital, Thiamylal
Block Ach conduction, inc GABA
Hepatic Elim
Onset 10-30 s, dec ICP, excit movement
minimal
Profound depression
No relax
Stim Porphyrin synth
Induce amnesia,no analgesia |
|
|
Term
Benzos
MOA
PKs
CNS
CV
Resp
MM
Renal/Liver
Status |
|
Definition
Diazepam, Midalozam, Lorazepam
Enhance GABA
PO, IM, IV (no IM for diazepam)
Cerebral BF metabolism and ICP reduced
none
none
*Central mediated muscle relax
none
Cont infusion in ICU |
|
|
Term
Etomidate
MOA
PKs
CNS
CV
Resp
MM
Renal/Liver
Status |
|
Definition
Enhance GABA
IV only
Onset 20-30 sec, invol MM movements
Preferred for CV unstable pts
Minimal
NO Mm relax
N/V common
Induction, no analgesia |
|
|
Term
Propofol
MOA
PKs
CNS
CV
Resp
MM
Renal/Liver
Status |
|
Definition
Enhance GABA
In fat emulsion
Onset 30-40 sec, excitatory movements
Drop in BP, SVR, reflex tachy
Profound depression
Small amount of muscle relax
none
Sedation |
|
|
Term
Ketamine
MOA
PKs
CNS
CV
Resp
MM
Renal/Liver
Status |
|
Definition
Blocks NMDA R
IM, IV
Dissociated Anmesia, quick onset, incr ICP and BF
Stimulatory to CV
Bronchodilator
May incr muscle tone
none
Great analgesic |
|
|
Term
Opiods
MOA
PKs
CNS
CV
Resp
MM
Renal/Liver
Status |
|
Definition
Binds opioid receptors
IM, IV, PO, epidural
Variable
Does not impair CV funct
DD resp depression
No muscle relax
Constipation
Adjunct to provide analgesia |
|
|
Term
Dexmedetomidine
MOA
PKs
CNS
CV
Resp
MM
Renal/Liver
Status |
|
Definition
alpha 2 agonist
IV, withdrawal symptoms
Analgesia
dec BP, HR
Little effect
None
none
Sedation of intubated pts in ICU |
|
|
Term
|
Definition
| Bind to Na channels in the inactive state |
|
|
Term
|
Definition
Esters are hydrolyzed by plasma esterases, Amides are metabolized by the liver and extensively bound to a-1 GLP
Amides are not for babies |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Faster, longer and more intense than procaine |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
