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Drug that displays the effect of epinephrine (inc. BP, HR, both) |
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Abscence of breathing
- Ex. OSA (Obstructive sleep apnea) |
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Injected (Drug) all at once |
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Any chemical produced out of Adrenal Medulla- Usually epi/NE |
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Drug works on Ach receptors |
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Introducing medicine slowly at a constant rate |
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Inc. cardiac contractility |
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(aka spinal anesthesia) injection given in subdural/subarachnoid space |
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Larger does given before infusion (purpose is to speed onset) |
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Provide analgesia only to area of injection (not entire body (like GA)) |
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Media effective dose (ED50) |
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Dose required to achieve a given effect in 50% of the population (the drug was given to) |
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Median lethal dose (LD50) |
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Dose that causes death in 50% of the population (the drug was give to) |
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1) Addictive drug 2) dec. pain 3) induces sedation 4) dec. respiratory drive |
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Opiod (5 key characteristics) |
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1) Opiate 2) Synthetic narctoic that resembles the naturally occuring opiates 3) Narcotic that contains opium 4) Contains opium-which is extracted from leaves 5) Opiod binds to opiate receptors |
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- Inc. HR, BP, or both (ex. Epinehrine) |
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1) Intial low dose 2) Dose is increased until desired effec is achieved 3) Dose is reduced if drug goes beyond desired effect |
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Dec. BP (NO is a vasodilator) |
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What is the ANS comprised off? |
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1) Sympathetic 2) parasympathetic |
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What are the effects of the sympathetic system? (6 effects) |
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1) Inc. HR 2) Inc. BP 3)Bronchodialation 4)Pupil dialation (mydrisis) 5) Gastroparesis (inhibits peristalsis) 6)Dry mouth |
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What are the neurotransmitters of the sympathetic system? |
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1) Epinephrine 2) norepinehrine |
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What ate the 5 effects of Parasympathetic system? |
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1) Dec. HR 2) Bronchoconstriction 3)Pupil constriction 4)Peristalsis 5) Inc. airway secretions/saliva |
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What are the NT associated with Parasymp.? |
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What are the two types of Ach receptors? |
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1) Nicotinic (on Sketelat Muscle) 2) Muscarinic (all other Ach recep) |
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What are the some nicotinic effects? |
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1) Receptor is activated=Muscle contraction
2) Receptor Blocking= Paralyzes patient |
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What are the effects of the Muscaranic receptor? |
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Definition
1) Receptor is activated= Parasympathetic(ex.neostigmine) response 2) Receptor is blocked= Sympathetic response (Atropine and Robinul) |
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Acetylcholinesterase: where is it found and what is its purpose? |
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Definition
1) In the NMJ, it is an enzyme 2) To break down Ach |
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What is an Acetylcholinesterase inhibitor? |
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Definition
1) Neostigmine- Stops the break down of Ach-To inc. ACh in body-which reverses muscle paralysis and cause parasymp. effects |
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What drug is given in congunction with Neostigmine (Anticholinesterase)? Why? |
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Definition
Robinul (Muscarinic blocker) is given b/c it prevents excess parasymp. stimulation, |
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What cautions may occur when giving neostigmine(anticholinesterase) and Robinul (Muscaranic blocker)? |
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Definition
1) Possible Tachycardia (from Robinul) when reversing paralysis |
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