Shared Flashcard Set

Details

Anemia Overview and Labs
Pharmacotherapy Fall 2013 Exam 3
47
Pharmacology
Professional
11/29/2013

Additional Pharmacology Flashcards

 


 

Cards

Term
types of aplastic anemia
Definition
neutropenia, thrombocytopenia and pancytopenia
Term
symptoms
Definition
fatigue, dizziness, fainting, low blood pressure, palpitations, enlarged spleen, yellowing of eyes, skin paleness, coldness, SOB, muscle weakness, changed stool color
Term
intensity of symptoms
Definition
level of anemai (Hgb, Hct), rapidity of change, co-morbidities
Term
reticulocytes
Definition
mesh-like network of ribasomal RNA which becomes visible with methylene blue
Term
causes of IDA
Definition
mestrual blood loss, GI blood loss, pregnancy or poor iron absorption
Term
uncommon
Definition
insufficient intake of iron
Term
foods high in iron
Definition
blackstrap molasses, clams,raisin bran cereal, turkey (dark), red meat
Term
symptoms of B12 deficiency
Definition
yellow pallor, neuro-findings, sore-beefy tongue, anorexia, tachycardia, palpitations, cardiomyopathy, heart failure
Term
causes of folate deficiency
Definition
ETOH abuse, pregnancy, malabsorption/ inadequate intake and some drugs
Term
drugs causing folate deficiency
Definition
phenytoin, MTX and colchicine
Term
S/Sx of hymolytic anemia
Definition
dyspnea/fatigue, dark urine, pale/jaundice, enlarged spleen, tachycardia/murmers
Term
most patients have no evidence of hemolysis until an event
Definition
infection, drug reaction (sulfa, anti-malarials, ASA, INH, or eating a lot of fava beans
Term
Male RBC counts
Definition
4.5-5.9
Term
Male Hgb counts
Definition
14-17.4
Term
Male HCT counts
Definition
41.5 - 50.4
Term
Female RBC counts
Definition
3.8-5.1
Term
Female Hgb counts
Definition
12.3 - 15.3
Term
Female HCT count
Definition
36-45
Term
Mean corpuscular volume (MCV)
Definition
80-96
Term
Increased MCV
Definition
Folate or B12 deficiency, chronic liver disease, chronic alcoholism, cytotoxic medications
Term
Decreased MCV
Definition
Iron deficiency, alpha/beta thalassemia (minor) and chronic disease (usually normocytic)
Term
Hypochromia
Definition
Increased in central clear area
Term
Microcytes
Definition
Iron deficient, anemia of chronic disease, alpha or beta thalassemia, decreased MCV
Term
Macrocytes
Definition
B12 deficient, folic acid deficient, alcoholism, some cytotoxic drugs, ususally increased MCV
Term
Schizocyte
Definition
Deformed broken cell, helmet cell, Burr cell, acanthpcyte, seen in mechanical valvular and hemolytic anemias
Term
Total body iron
Definition
65% Hgb, 4% yoglobin, 30% ferritin, serum transferrin
Term
Serum iron Men
Definition
35 to 190 mcg/dL
Term
Serum iron Women
Definition
30 to 150 mcg/dL
Term
Serum ferritin men
Definition
20-350 mcg/L
Term
Serum ferritin Women
Definition
6-250 mcg/L
Term
TIBC
Definition
240-450 mcg/dL
Term
Transferrin saturation
Definition
20-50%
Term
Schilling test
Definition
Determines the ability to absorb B12 form the GI tract (requires intrinsic factor)
Term
Abnormal Schilling test
Definition
Suggests pernicious anemia
Term
Causes of B12 deficiency
Definition
H2 antag, metformin, gastrectomy, poor dietary intake (limited meat and milk)
Term
Folate deficiency
Definition
Looks like pernicious anemia but does not have neurologic symptoms
Term
Giving folic acid to pernicious anemia
Definition
Worsens neurologic symptoms
Term
Causes of folate deficiency
Definition
Alcoholism, preggers, phenytoin, colchicine, MTX, BCPs?, some small bowel diseases
Term
Folic acid levels
Definition
5.4-24 by/mL
Term
DAT; Direct Coomb's (antiglobulin) test
Definition
Demonstrates presence of antibodies or complement on the surface of RBCs; hallmark of autoimmune hemolysis
Term
Hemolysis
Definition
Increased total bilirubin and unconjugated
Term
Normal total bilirubin levels
Definition
0.1-1.5 mg/dL
Term
Conjugated bilirubin
Definition
0.3 mg/dL
Term
Hgb electrophoresis
Definition
Used with suspected hemoglobinopathies and thalassimias
Term
Guaiac testing
Definition
Occult blood test
Term
False positive guaiac test
Definition
Meat consumption and high dose vitamin C
Term
Myriad cause of pos guaiac test
Definition
Malignancy, Uv/diverticulitis, others
Supporting users have an ad free experience!