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Anatomy Test Dr Johnson Ch 15
Ch 15
50
Anatomy
Undergraduate 4
03/29/2009

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Term
Autocrines
Definition
chemicals that exert effect on same cell that secretes them
Term
Paracrines
Definition
chemicals that act locally but on a different cell type than the one that transmits it.
Term
amino-acid based hormones
Definition
hormones that vary greatly in size and built from amino acids. act on receptors in plasma membrane.
Term
steriods
Definition
hormones made from cholesterol. only gonadal and adrenocortical hormones. act within a cell.
Term
eicosanoids
Definition
hormonal lipids. released by nearly all cell membranes.
Term
second messengers
Definition
method by which amino acid based hormones act on intercellular functions
Term
cAMP
Definition
specific type of secondary messanger commonly used.
Term
G protein
Definition
signaling protein that is inactive with GDP and active with GTP.
Term
Adenylate Cyclase
Definition
protein that g-protein binds to and activates or deactivates. ends up creating cAMP.
Term
Protein kinases
Definition
cAMP triggers activation of these proteins. Phosphorylate proteins in cells.
Term
phosphodiesterase
Definition
protein that breaks down cAMP
Term
PIP second-messenger mechanism
Definition
mechanism other than cAMP for affecting intercellular shit. amino-acid hormones.
Term
phospholipase C
Definition
G protein activates this protein in PIP system
Term
PIP2
Definition
what phospholipase splits
Term
DAG and IP3
Definition
result of PIP2 splitting by phospholipase C
Term
Calmodulin
Definition
activated downstream by CA2+ due to DAG creatinon from PIP2 by phospholipase C
Term
up-regulation
Definition
creation of new receptors on cell surface in response to target hormone
Term
down-regulation
Definition
desensitization of the target cell after lots of hormone is present. loss of receptors
Term
permissiveness
Definition
when hormone cant exert full effect due to lack of another hormone
Term
synergism
Definition
amplification of hormone response when more than one type of hormone are present
Term
antagonism
Definition
when one hormone opposes action of another hormone
Term
humoral stimuli
Definition
hormone release or nonrelease due to concentration of things in fluid (other than hormone)
Term
oxytocin and ADH
Definition
hormones made in hypothalamus and sent down infundibulum to the posterior pituitary
Term
primary capillary plexus through hypophyseal portal veins and then the secondary capillary plexus
Definition
way in which hypothalamus communicates with the anterior pituitary
Term
hypophyseal portal system
Definition
system used for hypothalamus to communicate with the anterior pituitary
Term
tropic hormones
Definition
hormones tht regulate secretion of other endocrine glands
Term
growth hormone
Definition
from anterior pituitary. controlled by ghih and ghrh of hypothalamus
Term
follicles
Definition
storage areas in the thyroid
Term
thyroglobulin
Definition
glycoprotein that will bind iodine to form colloid
Term
colloid
Definition
stored in the follicle of thyroid. consists of thyroglobulin bound to iodine.
Term
thyroid hormone
Definition
bodies major metabolic hormone
Term
T3 and T4 (T4 mainly)
Definition
combine to create thyroid hormone
Term
calorigenic effect
Definition
heat-producing effect of the TH
Term
goiter
Definition
caused by low levels of iodine in thyroid
Term
grave's disease
Definition
caused by too much iodine. autoimmune disease.
Term
calcitonin
Definition
produced by C cells (parafollicular cells) of the thyroid.
Term
parathyroid hormone
Definition
breakdown of bone
Term
corticosteroids
Definition
name of steroids synthesized in the cortex of the adrenal gland.
Term
mineralocorticoids
Definition
coirticosteroid involved with extracellular ion levels
Term
aldosterone
Definition
specific mineralocorticoid. important for maintaining level of sodium.
Term
angiotensin 2
Definition
renin and angiotensinogen combine to form...
Term
glucocorticoids
Definition
influence the levels of glucose in blood. released by adrenal cortex.
Term
gonadocorticoids
Definition
weak androgens secreted by the adrenal cortex. converted to testosterone.
Term
islets of langerhans
Definition
tiny cell clusters in teh pancreas that produce endocrine hormones.
Term
alpha cells
Definition
cell type in the islets of langerhans that produce glucagon
Term
beta cells
Definition
create insulin in the islets of langerhans
Term
glucagon
Definition
breaks gown glycogen stores in liver
Term
insulin
Definition
lowers blood glucose levels.
Term
Diabetes mellitus
Definition
inability of cells to use glucose as their food source. caused by hyposecretion or hypoactivity of insulin.
Term
atrial natriuretic peptide
Definition
reduces blood volume due to expansion of the atrium of the heart to abnormal limits. makes you pee more.
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