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the body’s second great controlling system which influences metabolic activities of cells by means of hormones |
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pituitary, thyroid, parathyroid, adrenal, pineal, and thymus |
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produce both hormones and exocrine products |
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has both neural functions and releases hormones |
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chemicals that exert their effects on the same cells that secrete them |
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locally acting chemicals that affect cells other than those that secrete them |
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These are not considered hormones since hormones are long-distance chemical signals |
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Autocrines and Paracrines |
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Are classified as amino acid-based hormones, or steroids |
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most hormones belong to this class |
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Amines, THYROXINE, peptide, and protein hormones |
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gonadal and adrenocortical hormones |
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Hormones alter target cell activity by one of two mechanisms: |
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1 Second Messengers
2 Direct Gene Activation |
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Amino-Acid Based horomones |
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2 Direct Gene Activation (TQ) |
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Steroid hormones and ______ hormones diffuse easily into their target cells |
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Once the steroid hormones and thyroid hormones are inside their target cells, they bind and activate a specific |
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The hormone-receptor complex __________________ and binds a DNA-associated receptor protein |
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Thyroid hormone acts like a ____________________ at cellular level but is a amino acid structure |
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Hormones circulate to all tissues but only activate cells referred to as _______________ . |
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Target cells must have ____________ to which the hormone binds |
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These receptors may be _____________or located on the __________. |
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intracellular Plasma Membrane |
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ACTH receptors are only found on certain cells of the ___________. |
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_____ receptors are found on nearly all cells of the body |
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Target cell activation depends on three factors.... |
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1. BLOOD levels of the hormone 2. RELATIVE NUMBER of receptors on the target cell 3. The AFFINITY of those receptors for the hormone |
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_______ and _______ are attached to plasma proteins (IMPORTANT)(protein-bound) |
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Concentrations of circulating hormone reflect: |
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Rate of release
Speed of inactivation and removal from the body |
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Hormones are removed from the blood by: |
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Degrading enzymes The kidneys Liver enzyme systems |
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Three types of hormone interaction: |
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-Permissiveness -Synergism -Antagonism |
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one hormone cannot exert its effects WITHOUT another hormone being present |
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more than one hormone produces the SAME EFFECTS on a target cell |
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one or more hormones opposes the action of another hormone |
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Blood Levels of Hormones are controlled by _________. |
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negative feedback systems |
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Hormones are synthesized and released in response to: (tq!) |
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Humoral stimuli Neural stimuli Hormonal stimuli |
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secretion of hormones in direct response to changing blood levels of IONS AND NUTRIENTS |
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nerve fibers stimulate hormone release |
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release of hormones IN RESPONSE TO HORMONES PRODUCED BY OTHER ENDOCRINE ORGANS |
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The hypothalamic hormones stimulate the ________ . |
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__________ modifies the stimulation of endocrine glands and their negative feedback mechanisms (tq) |
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The nervous system __________ normal endocrine controls |
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two-lobed organ that secretes nine major hormones |
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Receives, stores, and releases hormones from the hypothalamus |
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neurohypophysis- posterior lobe (neural tissue) and the infundibulum |
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anterior lobe, made up of GLANDULAR tissue Synthesizes and secretes a number of hormones |
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a downgrowth of hypothalamic neural tissue |
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The Posterior Lobe has a ___________hypothalamus |
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Nuclei of the hypothalamus synthesize ... |
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oxytocin and antidiuretic hormone (ADH) |
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These hormones are transported to the posterior pituitary TQ |
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There is no ___________________ with the hypothalamus and the anterior pituitary |
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There is a vascular connection, the hypophyseal portal system, consisting of: |
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The primary capillary plexus The hypophyseal portal veins The secondary capillary plexus |
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The six hormones of the adenohypophysis:(TQ) |
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Are abbreviated as GH, TSH, ACTH, FSH, LH, and PRL Regulate the activity of other endocrine glands |
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The hypothalamus sends a ______ stimulus to the anterior pituitary |
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_________ hormones stimulate the synthesis and release of hormones |
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________ hormones shut off the synthesis and release of hormones |
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The tropic hormones that are released are: |
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Thyroid-stimulating hormone (TSH) Adrenocorticotropic hormone (ACTH) Follicle-stimulating hormone (FSH) Luteinizing hormone (LH) |
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Produced by somatotropic cells of the anterior lobe that: Stimulate most cells, but target bone and skeletal muscle Promote protein synthesis and encourage the use of fats for fuel |
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Stimulates the adrenal cortex to release corticosteroids Triggered by hypothalamic corticotropin-releasing hormone (CRH) in a daily rhythm |
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Adrenocorticotropic Hormone (Corticotropin)*** |
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Absent from the blood in prepubertal boys and girls Triggered by the hypothalamic gonadotropin-releasing hormone (GnRH) during and after puberty |
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made of axons of hypothalamic neurons, stores antidiuretic hormone (ADH) and oxytocin |
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___ and ___ synthesized in the hypothalamus (TQ) |
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