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Analgesics & Anesthesia
Week 3 (quiz 1)
78
Pharmacology
Undergraduate 4
02/08/2012

Additional Pharmacology Flashcards

 


 

Cards

Term

Sources of pain

Definition

Superficial = skin

 - localized

Somatic = skeletal (muscles/joint pain)

 - More likely to be able to pinpoint pain

Visceral = deep pain (smooth muscles/organs)

 - frequently referred to other dermatomes

 - harder to define as limited to one area

Term

Magnitude of acute pain

Definition

  How bad the pain can be...


 

 

Most common complaint presented to healthcare providers

 

National Center for Health Studies Data               >65 million injuries per year      >80% cause acute pain

>24 million surgical procedures per year          Millions of lost work days per year

Term

Pain Management Principles

Definition
  • Pain is a universal experience
  • Each person’s pain experience is unique
  • Pain is subjective
  • Included as the 5th vidtal sign
  • Pain impairs healing and decreases immune function


Term

Nurses' roles in Pain Management

Definition

 

  • Nurses must appropriately assess pain
  • Nurses need to be knowledgeable about pain and how to relieve it
  • Potent analgesics are available, safe, and effective when properly used
  • If the med being used is not effective and nonpharmacologic  interventions do not work, you must consult with MD
Term

 

Managing Acute Pain

Definition
  • Treat pain aggressively - as early as possible
  • Risk of pain > risk of drugs
  • High doses often needed to establish comfort
  • Assess and reassess pain regularly
  • Empower and encourage patients to report pain
  • Establish pain management plans
  • Clearly defined lines of responsibility
Term

Nursing management of Pain

Definition

 

  • Accurate and frequent assessments
  • Adequate intervention
  • Pharmacologic
  • Nonpharmacologic
  • Monitor effect of intervention
  • Onset and peak depends on drug and route
  • Side effects
Term

Nursing Process in Pain Management

Definition

 Assess your patient before giving any analgesic

    • Take vital signs  
    • Check pupils (PERLA)  
    • Check allergies  
    • Know other medications the patient is on
  • Document medication after it is given:
  • Educate patient
  • administer pain medication before pain reaches its peak to maximize effectiveness
  • Evaluate and monitor response
  • Refusal

 

Term

Most important vital sign to monitor while a patient is on pain medications

Definition

RESPIRATIONS!

Term

Analgesic Classifications

Definition

 
Narcotic (addictive)

  • Narcotic: can cause narcosis (stupor)
  • Can lead to drug dependence      
  • Abuse potential is high
  • Examples: Morphine, Hydrocodone,
  • Can be called the Opiates: opium poppy
  • Non-narcotic (not addictive)
    • Less potent than the narcotic analgesics
    • Generally do not lead to drug dependence
    • Examples: ASA, Tylenol, Ibuprofen

 

Term

ANALGESIC ACTION

Definition

 

 

Narcotics

 

  • Act on the central nervous system=CNS     (brain and spinal cord)
  • Produce greater analgesia than even high doses of non-narcotics

 

Non-narcotics

 

  • Act primarily on the peripheral nervous system  (voluntary and autonomic)

 

Term

Opioid Analgesics

Definition

 

 

Mechanism of action is r/t binding with receptors

 

  • Mu (μ), kappa (ΔΈ), delta (δ), sigma (σ)
  • Produce analgesia, altered perception of pain   
  • Also the unwanted effects (constipation, respiratory depression, etc)

 

Term

NARCOTICS

Definition

 

 

 

Also called narcotic analgesics or narcotic agonists

 

  • An agonist = a drug that produces a response     
    • binds with receptor
  • Partial agonist—produces a partial response
  • Agonist-antagonist—mixed effects on receptors

 

Term

Action

Definition

 

 

Suppress pain impulses

 

  • Morphine – moderate to severe pain
  • Codeine – mild to moderate pain

 

Suppress respiratory and cough centers in the medulla

 

  • A drug that suppresses a cough is called an antitussive

 

Term

NARCOTICS: SIDE EFECTS

Definition
  • Respiratory depression
    • Normal respiratory rate = 12-20 breaths per minute in an adult 
    • Respiratory depression = < 10
  • Decrease in Blood Pressure (B/P):   
    • Normal 120/80 mmHg    
    • Low B/P = 90/60 mmHg
  • Respiratory Depression   
    • Onset within minutes IV    
    • Persists for 4-5 hours
    • If given via spinal routes, can last longer  
  • Must be prepared to intervene
    • BVM (bag valve mask) & supplemental 02
    • Reversal drugs
    • Protect airway (suction and positioning)

 

Term

 NARCOTIC OVERDOSE 

Definition

 

Example: morphine overdose

 

  • Pinpoint pupils     
  • Bradypnea < 8    down to  respiratory arrest

 

Opiates increase the effect of:

 

  • Alcohol
  • Sedatives (to sedate)  
  • Hypnotics (for sleep)
  • Antipsychotic meds       
  • Muscle relaxants

 

Term

ANTIDOTES: Narcotic Antagonists

Definition

Drugs used for overdose of narcotic analgesic       

  • A narcotic antagonist
    • Blocks receptor site and displaces the narcotic
    • Action: these drugs have a higher affinity to the opiate receptor site than the narcotic taken
  • Narcan (Naloxone)
    • reverses the effects of respiratory and CNS depression!
  • Half life is shorter than the narcotic. Usually must repeat
  • If unknown OD substance, give anyway

 

Term

Other common SE of opioids

Definition

 

 

  • Constipation & biliary colic      
  • Orthostatic hypotension       
  • Urinary retention
  • Nausea especially in ambulatory patients      
  • Sedation    
    • High falls risk; cannot operate machinery
    • DWI         
    • Cannot make legal decisions (Consent forms)

 

Term

NARCOTIC: MORPHINE

Definition

 

Used for moderate to severe pain    

e.g., chest pain, acute myocardial infarction (MI) 

 

ADME

  • Administration    
    • PO, IM, IV, SC, PR, epidural, intrathecal
  • Distribution     
    • Wide, passes blood-brain barrier

 

Term

MORPHINE: Effects

Definition

 CNS:  drowsiness, lethargy, apathy, alters mood; decreases anxiety

 Resp:  depression (effect on resp center)

 Assess rate and depth

 GI:  stimulates vomiting center, decreases peristalsis and increases sphincter tone

 Eye:  miosis

 GU:  diminished sensation to void

 CV:  hypotension, flushing of upper body (not allergy)

 

Term

Morphine Dose     

Definition

Dependent on Route

  • IV:  1-10 mg per dose    
  • PCA:  (Patient Controlled Analgesia)
  • IM:  5-20mg      
  • PO:  10-30mg
  • SQ (same as IM)
  • Epidural, intrathecal  (must be preservative free- don't want preservative-induced meningitis)
  • Rectal
Term

Morphine: Indications

Definition

Indications:  Moderate to severe pain

  • Higher doses initially, or if patient is developing tolerance
  • More effective before pain reaches intolerable levels
  • Schedule pain-causing activities for when drug will be most effective (e.g., bandage changes)

Fixed schedules more effective than “as needed”

More common for MD or RN to give too little than too much narcotic

PCA now commonly used to deliver

 

Term

PCA   

Definition

Patient Controlled Analgesia

  • Pump with controller to push for a dose     
  • Set dose with each request
    • mg per dose and # times per hour
  • Can also have a basal rate      
    • Some drug is constantly provided
  • Lock out prevents too many doses given in too short a time
Term

Benefits of PCA

Definition

 

  • No waiting in agony for nurse to come
  • Smaller doses = less sedation and respiratory depression
  • Patient is empowered
  • Studies show less over use of opioids post op than if given on schedule or prn.

 

Term

Tolerance (Morphine, opioids)

Definition

 

  • Larger and larger doses needed for same effect
    • analgesic, euphoric, sedative and respiratory depression effects
  • Tolerance to respiratory depression is good because when need higher doses of drug, the risk remains relative
  • There can be cross tolerance between drugs
Term

Physical Dependence on Opioids

Definition

 

The body reacts when dose drops or not given

 

Occurs about 6-10 hours after last dose

 

Reactions include: severe body aches, cramps, racing heart, shivering, shaking, fever,  runny nose and keen irritability

 

Dose helps, but stimulation of Dopaminergic Reward system never reaches original high.  Need more and more to sorta achieve it.

 

Term

Who should not get a basal rate on their PCA pump?

Definition

Narcotic-naive

A person who does not typically take pain meds

 

Term

Other Pure Narcotic Agonists: Meperidine (Demerol)

Definition

 

 

Action: same potency but shorter action than Morphine

 

  • Does NOT have an antitussive (cough suppressant) effect
  • Given to patients after surgery
  • For pain control if allergic to morphine
  • To stop the massive shivers that can get when awakening

 

Term

Other Pure Narcoic Agonists: Fentanyl (Sublimaze, Innovar, Duragesic

Definition

 

Is 100 X stronger than morphine!!

 

Primarily used as an adjunct to anesthesia   

Can be used in PCA pump

 

Patch for severe chronic pain;

Actiq:  lollipop (will kill a child)

 

  • Effects like oral or IV opioids
  • Heat lamps and hot packs will increase absorption rate     

 

Term

Other Pure Narcotic Agonists: Codeine

Definition

 

  • 1/10th the analgesic potency of MS, 5 times the potency of ASA or acetaminophen
  • Is metabolized to morphine!
  • Some folks have genetic block to metabolizing it
  • Mild to moderate pain      Not as sedating; no increase in ICP like MS
  • Common to mix with ASA or acetaminophen to achieve two different types of analgesia

 

Term

More pure narcotic agents: Diacetyl morphine (Heroin)

Definition

 

  • More lipid soluble than MS, enters brain faster; but not stronger on pain
  • Converted to MS in the body
  • Schedule I drug—no legal use in US
  • Frequently “cut’ with other substances    
    • Those substances may be lethal or cause the OD
Term

More pure narcotic agonists: Methadone

Definition

 

Analgesic = MS

 

Longest duration of action of any narcotic

 

Used for detox or maintenance (withdrawal is milder, more gradual)

 

Patient is still using a narcotic

 

May be delivered daily at a clinic     

Has less of a “buzz” than MS  

Tolerance develops and seek other drugs

 

Term

Hydrocodone (Vicodin)

Definition

 

  • Used as an analgesic and antitussive
  • Commonly prescribed for outpatients
Term

Oxycodone (Percodan, Percocet)

Definition

 

  • 10 x more potent than codeine, available in combo with ASA or Tylenol and ibuprofen,
  • extended release form (OxyContin)
  • Commonly Rxd for outpatients

 

Term

 

Narcotics For Non-Narcotic Uses:

Lomotil

diphenoxylate/atropine

 

Definition

For managing diarrhea

(Davis p. 453 if more info needed)

Term

Narcotics for Non-Narcotic Uses: Antitussives

Definition

 

  • Codeine and hydromorphone—effective but have abuse potential
  • Dextromethorphan—chemically related to opiates but few effects other than antitussive so is in many OTCs
Term

-dan

(drug name suffix)

Definition
mixed with ibuprofen
Term

-cet

(suffix in drug name)

Definition
mixed with acetaminophen
Term

 

Opioid-Like Analgesic

 

Definition

 

Prototpye:  tramadol (Ultram)

 

  • Synthetic, not related to opioids but binds to mu receptors
  • For moderate to moderately severe pain
  • Not for use in patients who have a narcotic dependence or are addicted
  • Has high street value
Term

Non-narcotic Analgesics: NSAIDS

Definition

 

  • Nonsteroidal anti-inflammatory drugs (NSAIDS) – reduce pain by inhibiting chemical mediators
  • Inhibit prostaglandins by interacting and interfering with cyclooxygenase  (COX1)
    • Analgesics         
    • Antipyretics

 

Term

Blocking COX1: pros/cons

Definition

BAD

  • Gastric ulcers that can bleed to death
  • Definite gastritis issues

Possible Good

  • Inhibition of platelet aggregation
  • Antipyretics
  • Don’t need to use opioids
Term

Asprin (acetlysalicylic acid)

ADME

Definition

 

  • Well absorbed in GI tract, acidic environment improves absorption, buffering slows it but protects gastric mucosa to some extent
  • Half life of 15 min in single usual dose but can be extended to 20 hrs in overdose situations (can’t be excreted fast enough)

Highly protein-bound

Term

Asprin: Effects

Definition

 

  • Inhibits enzyme cyclooxygenase which is needed in the synthesis of prostaglandins
  • works in peripheral sensory nerves, no physical dependence;
  • doesn’t work for visceral pain but is good for HA, muscle and joint pain and especially when inflammation present
Term

Asprin: actions

Definition

 

  • Anti-inflammatory
  • Suppresses inflammation (antiprostaglandin)
  • Antipyretic
  • Inhibits formation of fever-causing substances that raise body’s thermostatic controls
  • Antiplatelet
  • Decreases the stickiness of platelets ~ 7 days
  • Prevents colon cancer
  • Prophylaxis of recurrent MI or stroke
Term

Asprin: Indications

Definition

 

  • Indications
  • Pain, inflammation, or fever
  • Associated with Reye’s syndrome in children when given for viral illnesses
Term

Asprin: Drug-drug interactions

Definition

 

  • Heavily protein bound
  • Anticoagulants
  • Alters pH (metabolic acidosis)
  • Gastric irritation is additive with NSAIDs
  • ETOH—both are ulcerogenic
Term

Asprin: Toxicity

Definition

 

Mild (salicylism)

 

  • Tinnitus, HA, dizziness, drowsiness, confusion, paresthesias, ventilatory stimulation, GI distress

 

Salicylate poisoning

 

  • Altered resp (increased rate, then depression)
  • Altered fluid/lytes and acid-base balance (alkalosis to acidosis)

 

Term

Asprin Toxicity Treatment

Definition

 

Treatment—the sooner the better, no antidote

  • Induce emesis,
  • Ventilatory support,
  • Correct acid-base balance
  • Hasten excretion
  • Watch for possible GI bleeding
  • Expect effects of severe anticoagulation
  • Renal failure if already renal insufficiency

 

Term

Other NSAIDS (basics)

Definition

 

  • Not salicylates but share many of the common SE and contraindications
  • All have the same general pharmacokinetics
  • Indications are similar, cost is greater
  • May give less frequently
  • All are ulcerogenic but not as great as ASA
  • Many different drugs on the market, many are OTC
Term

Ibuprofen

Definition

 

  • Very common use, Rx and OTC strengths
  • Causes sodium and water retention
  • Caustic to stomach and intestinal lining
  • Massive GI bleeds
  • Can occur without warning
  • Can cause renal damage
  • Good Pain control
  • Anti-inflammatory

 

Term

NSAIDS & Muscle Injury

Definition

 

Strain (stretch-induced injury)

 

Animal studies:  Delayed healing

 

Human study:  No different than placebo

 

Term

NSAIDS & Contusions

Definition

 

  • No studies in humans
  • Equivocal at best or slow adaptation to training
  • At best NSAIDs are disappointing

 

Term

NSAID & Ligament Injury

Definition

 

  • Injuries heal best with controlled mobilization
  • If NSAIDS promote mobilization, then perhaps beneficial.
  • Most heal in spite of us
  • Not sure if effect is from pain relief or anti-inflammatory effect
Term

NSAIDS & Bone

Definition

 

  • Animal studies show inhibit fracture healing.
  • Indomethacin and naproxen inhibit ossification after hip fracture and total hip replacement
  • Marked association between non-union and delayed healing in those who take NSAIDS
Term

How to decrease risk of RENAL issues when taking ibuprofen

Definition
Drink with full glass of water
Term

COX-2 Inhibitors

Definition

 

  • Prototype: celecoxib (Celebrex)
  • Pain relief similar to ibuprofen or naproxen—inhibits cyclooxygenase (COX)
  • Less ulcerogenic (?), fewer SE      
  • More expensive
  • Now used for acute post-op or trauma pain
  • Probable increase CV risk
  • Even Celebrex
  • Even Naproxen and Ibuprofen, but to a lesser degree
Term

NSAIDs: Things to ponder

Definition

 

  • If taken ASA and Cox-1 ASA effect stopped
  • Less likely with COX-2
  • NSAIDS should not be popped like candy
  • Patients should not remain in pain for slight risk of CV event for short term use
  • Other therapeutic interventions are very important---not just drugs
Term

 

Acetaminophen: Effect & ADME

Analgesic (but not anti-inflammatory)

 

Definition

Effects

  • Antiprostaglandin but apparently effects only certain types of cells – inhibits the synthesis of prostaglandins thereby reducing pain – more central mechanism than peripheral

ADME

  • Well-absorbed, metabolized in liver

 

Term

How acetaminophen differs from ASA

Definition

 

  • No anti-inflammatory action
  • Does not inhibit platelet aggregation
  • Rare gastric irritation
  • Not likely to cause bronchoconstriction in patients allergic to ASA
  • Fewer drug-drug interactions
  • No risk of Reye’s
Term

Tylenol Indications & Side Effects

Definition

 

  • Relief of mild pain and fever

Side effects:

  • Few with normal dosage
  • Danger is with long-term use or OD
  • Liver damage if also ETOH 2-4X a day
  • Can’t be used by liver cancer or cirrhosis patients

MAKE NOTE:  Max dose just changed to 3 GM a day

Term

Tylenol Toxicity

Definition

 Fairly common (OD 25 gm for an adult)

  • At its worst, fatal liver damage
    • 12-24 hr:  GI cramping, N/V
    • 2nd day:  no obvious signs, relief; urine output drops, hematuria, pain in URQ
    • 3-5 days:  hepatic necrosis, irreversible
  • Treatment:  N-acetylcysteine (Mucomyst)
    • Interacts with toxic metabolite, protects liver cells
    • Best if given within 10-12 hrs after ingestion
Term

Anesthetics

Definition

 

  • CNS depressants
  • Loss of sensation, esp. to pain
  • Types
  • General—state of unconsciousness, surgery
  • Regional—larger body region, target nerves
  • Local—small body region, procedural area
Term

 

Pre-anesthetics

 

Definition

Action: reduce undesirable effects of anesthesia, reduce apprehension

 

Common agents

  • Narcotics—
  • Barbiturates or Benzodiazepines
  • Phenothiazines—like promethazine for nausea control
  • Anticholinergics— like atropine (for airway secretion control)
  • Skeletal muscle relaxants

 

Term

General Anesthesia

Definition

 

2 classes of anesthetics

 

  • Inhalation (gases or liquids)
  • IV agents

 

Balanced anesthesia involves a combo of drugs, each with a specific effect

 

Pre-op agents

 

Intra-op agents

 

Term

Stages of General Anesthesia

Definition

 

  • Stage 1 – analgesia     
    • Administration to loss of consciousness
  • Stage 2 – excitement    
    • Reflexes still present, may be exaggerated
  • Stage 3 – surgical anesthesia     
    • Increasing depth of anesthesia, affects respiration, loss of reflexes, flaccidity, lower body temperature
  • Stage 4 –
    • medullary paralysis (toxic)     
      • Respiratory arrest and vasomotor collapse

 

Term

Inhalation Anesthetics

Definition

 

  • Nitrous oxide     (Not nitric oxide)
  • Most often used in dental surgery
  • 100% excretion through lungs
  • High analgesia unlike other gases, but with low anesthesia

 

Term

Volatile Liquids (mixed with oxygen)

Definition

 

  • Halothane, Isoflurane, Ethrane
  • Can be mixed with nitrous
Term

IV Anesthetics

Definition

 

 

  • Used for induction and/or maintenance, seldom used alone

 

 

 

Term

Recovery Considerations

Definition

 Most anesthetic agents are lipid-soluble...

  • Take VS every 15 minutes or sooner
  • RR and airway: critical to monitor
  • Some folks shiver as SE of med     
    • Can also be from cold room
    • Warm them up!
  • Groggy and uncoordinated
    • High falls risk
    • Can’t drive home
Term

Regional & Local Anesthesia

Definition

 

  • Action
    • Stabilizes or elevates threshold of excitation of nerve cells, prevents depolarization and transmission of nerve impulses
  • Effect    
    • loss of sensation without skeletal muscle involvement
  • Types
    • Topical
    • Infiltrates—tissue, nerve, spinal

 

Term

Topical Anesthetics

Definition

 

  • Solution, ointment, cream, placed directly on skin or mucous membranes
  • Effect
    • Affects distal nerve endings, relieves pain or itching (loss of pain first, then warmth, pressure)
  • “BenGay” is real medicine
  • Choice depends on duration of action
    • Short—1/2-1 hr     (lidocaine)     
    • Intermediate—1-3 hr
    • Long—3-10 hr   (Marcaine)
  • Some contain epinephrine—local vasoconstriction
Term

 

“Fingers, Ears, Nose, Toes and OHs”

 

Definition
Places NOT to use epinephrine! 
Term

What adverse reaction can occur r/t genearl anesthesia drugs?

Definition
Malginant Hyperthermia
Term

Local Anesthetics: ADME

Definition

 

  • Alert: When used in mouth can interfere with swallowing/gag reflex
    • We don't want to cause an aspiration because we didn't check the gag reflex! 
    • Viscous Xylocaine for sore throat
  • Sprays given prior to endoscopy
Term

Malignant Hyperthermia

Definition

Happens to certain groups of individuals (genetically predisposed)

Hypothalamus goes "offline" and temperature rises uncontrollably

Certain drugs more likely to have this effect than others

 

Term

Local anesthetics: Nursing Management

Definition

 

  • Monitor VS, watch for SE
    • Watch for systemic effects
  • If mixed with epinephrine can cause ischemia in the area.
    • Why it's especially important to avoid epi on distal extremities
  • Can be mixed with anti-inflammatory for dual action
Term

Spinal Anesthesia

 

Definition

 Putting numbing agents into CSF to cause numbness from waist down.

  • Can awaken with HA (headache)
    • ??if occurs due to suggestion
      • Nursing research showed that when people weren't warned of possible headache, they didn't occur.
    • Usually only with larger loss of fluid
    • Typically on flat position bedrest X 12 hours
  • Cannot be released if cannot void
  • Shaking and moving extremities does not hasten recovery
    • Don't try and "shake it off"
  • High falls risk 
Term

Propofol

Definition
  • IV anesthetic
    • Rapid onset and short duration
    • Can be used outside OR in continuous infusion
  • SE:  PROFOUND respirations and hypotension
    • Caution in hypovolemia and CVD
  • Increase risk of bacterial infection WHY????
    • You can't flush it with a lot of stuff (it's thick, stickier... bacteria like to stick to it)
  • Can’t be used with Egg allergies
    • egg protein
Term

Non-pharmacologic Interventions in Pain Management

Definition

Positioning

Ice/heat (though needs an order, officially)

Distraction (TV)

"Massage" (but don't call it that, also requires an order)

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